Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review)
The study of wound‑healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are availab...
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| Veröffentlicht in: | Molecular medicine reports 2017-03, Vol.15 (3), p.1007-1016 |
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| creator | Vijayaraghavan, Kavitha Rajkumar, Johanna Bukhari, Syed Nasir Abbas Al-Sayed, Badr Seyed, Mohammed Ali |
| description | The study of wound‑healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. However, it exhibits anti‑inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable healthcare, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future drug design, development and application for the treatment of wounds. |
| doi_str_mv | 10.3892/mmr.2017.6133 |
| format | Article |
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Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. However, it exhibits anti‑inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable healthcare, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future drug design, development and application for the treatment of wounds.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2017.6133</identifier><identifier>PMID: 28112383</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Acids ; Analgesics ; Antioxidants ; Asteraceae ; Biological activity ; Chromolaena - chemistry ; Chromolaena odorata ; Cytokines ; Cytotoxicity ; Drug development ; Eupatorium ; Flavonoids ; Free radicals ; Health aspects ; Herbal medicine ; Inflammation ; Injuries ; Medicine ; Medicine, Traditional ; Metabolites ; Methods ; Phytochemicals - chemistry ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Preparations - chemistry ; Plant Preparations - pharmacology ; Plants, Medicinal - chemistry ; Studies ; Wound healing ; Wound Healing - drug effects</subject><ispartof>Molecular medicine reports, 2017-03, Vol.15 (3), p.1007-1016</ispartof><rights>COPYRIGHT 2017 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-718f9cf39e640eceb1501aba48e4830a7c9a29cc99879e46d7d0849e8ddd711b3</citedby><cites>FETCH-LOGICAL-c427t-718f9cf39e640eceb1501aba48e4830a7c9a29cc99879e46d7d0849e8ddd711b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28112383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vijayaraghavan, Kavitha</creatorcontrib><creatorcontrib>Rajkumar, Johanna</creatorcontrib><creatorcontrib>Bukhari, Syed Nasir Abbas</creatorcontrib><creatorcontrib>Al-Sayed, Badr</creatorcontrib><creatorcontrib>Seyed, Mohammed Ali</creatorcontrib><title>Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review)</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The study of wound‑healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. 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| ispartof | Molecular medicine reports, 2017-03, Vol.15 (3), p.1007-1016 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acids Analgesics Antioxidants Asteraceae Biological activity Chromolaena - chemistry Chromolaena odorata Cytokines Cytotoxicity Drug development Eupatorium Flavonoids Free radicals Health aspects Herbal medicine Inflammation Injuries Medicine Medicine, Traditional Metabolites Methods Phytochemicals - chemistry Plant Extracts - chemistry Plant Extracts - pharmacology Plant Preparations - chemistry Plant Preparations - pharmacology Plants, Medicinal - chemistry Studies Wound healing Wound Healing - drug effects |
| title | Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review) |
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