Transient Neonatal Zinc Deficiency Caused by a Novel Mutation in the SLC30A2 Gene
This is a case report of a 4‐month‐old full‐term, fully breastfed boy who presented with a persistent periorificial and groin rash associated with poor weight gain and irritability. His serum zinc level was low. The mother's breast milk zinc level was found to be low despite her serum zinc leve...
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| Veröffentlicht in: | Pediatric dermatology 2017-03, Vol.34 (2), p.e104-e105 |
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| container_title | Pediatric dermatology |
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| creator | Liew, Hui M. Tan, Colin W. Ho, Clement K. M. Chee, Jade N. Koh, Mark J. A. |
| description | This is a case report of a 4‐month‐old full‐term, fully breastfed boy who presented with a persistent periorificial and groin rash associated with poor weight gain and irritability. His serum zinc level was low. The mother's breast milk zinc level was found to be low despite her serum zinc levels being normal, confirming the diagnosis of transient neonatal zinc deficiency. Mutational analysis revealed a novel mutation in the mother's SLC30A2 gene, which encodes a zinc transporter expressed in mammary gland epithelial cells. |
| doi_str_mv | 10.1111/pde.13065 |
| format | Article |
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Mutational analysis revealed a novel mutation in the mother's SLC30A2 gene, which encodes a zinc transporter expressed in mammary gland epithelial cells.</description><identifier>ISSN: 0736-8046</identifier><identifier>EISSN: 1525-1470</identifier><identifier>DOI: 10.1111/pde.13065</identifier><identifier>PMID: 28111782</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Breast milk ; Cation Transport Proteins - genetics ; Epithelial cells ; Exanthema ; Growth Disorders - genetics ; Growth Disorders - pathology ; Humans ; Infant ; Male ; Mammary gland ; Milk ; Milk, Human - chemistry ; Mutation ; Mutation - genetics ; Neonates ; Newborn babies ; Nutrient deficiency ; Zinc ; Zinc - deficiency ; Zinc transporter</subject><ispartof>Pediatric dermatology, 2017-03, Vol.34 (2), p.e104-e105</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>Copyright © 2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpde.13065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpde.13065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28111782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liew, Hui M.</creatorcontrib><creatorcontrib>Tan, Colin W.</creatorcontrib><creatorcontrib>Ho, Clement K. 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Mutational analysis revealed a novel mutation in the mother's SLC30A2 gene, which encodes a zinc transporter expressed in mammary gland epithelial cells.</description><subject>Breast milk</subject><subject>Cation Transport Proteins - genetics</subject><subject>Epithelial cells</subject><subject>Exanthema</subject><subject>Growth Disorders - genetics</subject><subject>Growth Disorders - pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Mammary gland</subject><subject>Milk</subject><subject>Milk, Human - chemistry</subject><subject>Mutation</subject><subject>Mutation - genetics</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Nutrient deficiency</subject><subject>Zinc</subject><subject>Zinc - deficiency</subject><subject>Zinc transporter</subject><issn>0736-8046</issn><issn>1525-1470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkclOwzAQhi0EoqVw4AWQJS5cUrzES45VWgpSKSDKhYvlJFORKnVKFlDeHneBA76MNfPNzK_5EbqkZEj9u91kMKScSHGE-lQwEdBQkWPUJ4rLQJNQ9tBZXa8IIVpKeop6TPs2pVkfvSwq6-ocXIPnUDrb2AK_5y7FY1jmqc-nHY5tW0OGkw5bPC-_oMCPbWObvHQ4d7j5APw6izkZMTwFB-foZGmLGi4OcYDe7iaL-D6YPU0f4tEsWPFQiMBv1wmNMkioIpIILz9KuCSJTXiqGVglwxDAq-fcakY5UK2USiMGJGFS8AG62c_dVOVnC3Vj1nmdQlFYB2VbG6olFRFjEfHo9T90VbaV8-oMjRgRoeRsO_DqQLXJGjKzqfK1rTrzeywP3O6B77yA7q9Oidm6YLwLZueCeR5Pdh_-A5ttdMg</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Liew, Hui M.</creator><creator>Tan, Colin W.</creator><creator>Ho, Clement K. 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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Neonatal Zinc Deficiency Caused by a Novel Mutation in the SLC30A2 Gene</atitle><jtitle>Pediatric dermatology</jtitle><addtitle>Pediatr Dermatol</addtitle><date>2017-03</date><risdate>2017</risdate><volume>34</volume><issue>2</issue><spage>e104</spage><epage>e105</epage><pages>e104-e105</pages><issn>0736-8046</issn><eissn>1525-1470</eissn><abstract>This is a case report of a 4‐month‐old full‐term, fully breastfed boy who presented with a persistent periorificial and groin rash associated with poor weight gain and irritability. His serum zinc level was low. The mother's breast milk zinc level was found to be low despite her serum zinc levels being normal, confirming the diagnosis of transient neonatal zinc deficiency. 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| ispartof | Pediatric dermatology, 2017-03, Vol.34 (2), p.e104-e105 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Breast milk Cation Transport Proteins - genetics Epithelial cells Exanthema Growth Disorders - genetics Growth Disorders - pathology Humans Infant Male Mammary gland Milk Milk, Human - chemistry Mutation Mutation - genetics Neonates Newborn babies Nutrient deficiency Zinc Zinc - deficiency Zinc transporter |
| title | Transient Neonatal Zinc Deficiency Caused by a Novel Mutation in the SLC30A2 Gene |
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