The prognostic value of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review
BACKGROUND AND OBJECTIVES The detection of a simple and reliable prognostic biomarker for colorectal cancer (CRC) outcomes remains a significant challenge. The use of neutrophil‐to‐lymphocyte ratio (NLR), has been reported to predict surgical and survival outcomes. The aim of our review was to asses...
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| Veröffentlicht in: | Journal of surgical oncology 2017-03, Vol.115 (4), p.470-479 |
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| container_title | Journal of surgical oncology |
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| creator | Haram, Abdelhamed Boland, Michael R. Kelly, Michael E. Bolger, Jarlath C. Waldron, Ronan M. Kerin, Michael J. |
| description | BACKGROUND AND OBJECTIVES
The detection of a simple and reliable prognostic biomarker for colorectal cancer (CRC) outcomes remains a significant challenge. The use of neutrophil‐to‐lymphocyte ratio (NLR), has been reported to predict surgical and survival outcomes. The aim of our review was to assess the predictive value of pre‐operative NLR in predicting post‐operative outcomes in CRC.
METHODS
A systematic review of the available studies on NLR in CRC was performed. Primarily, we assessed its ability to predict survival outcomes, and highlight values that would help adjuvant therapy choices.
RESULTS
19 studies comprising 10 259 patients were included. Eleven and eight studies reported on patients with localized CRC and colorectal liver metastasis, respectively. Five‐year survival for those with localized CRC was 77.2% in patients with a “low” pre‐operative NLR versus 50.8% in those with a “high” pre‐operative NLR value. Alternatively, for patients with colorectal liver metastasis, patients with a “high” pre‐operative NLR value had a 5‐year survival of 27%.
CONCLUSION
Elevated pre‐operative NLR>5 is associated with poorer long‐term survival in both patients with localized CRC and those with liver metastasis. NLR is a useful biomarker in delineating those patients with poorer prognosis and whom may benefit from adjuvant therapies. |
| doi_str_mv | 10.1002/jso.24523 |
| format | Article |
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The detection of a simple and reliable prognostic biomarker for colorectal cancer (CRC) outcomes remains a significant challenge. The use of neutrophil‐to‐lymphocyte ratio (NLR), has been reported to predict surgical and survival outcomes. The aim of our review was to assess the predictive value of pre‐operative NLR in predicting post‐operative outcomes in CRC.
METHODS
A systematic review of the available studies on NLR in CRC was performed. Primarily, we assessed its ability to predict survival outcomes, and highlight values that would help adjuvant therapy choices.
RESULTS
19 studies comprising 10 259 patients were included. Eleven and eight studies reported on patients with localized CRC and colorectal liver metastasis, respectively. Five‐year survival for those with localized CRC was 77.2% in patients with a “low” pre‐operative NLR versus 50.8% in those with a “high” pre‐operative NLR value. Alternatively, for patients with colorectal liver metastasis, patients with a “high” pre‐operative NLR value had a 5‐year survival of 27%.
CONCLUSION
Elevated pre‐operative NLR>5 is associated with poorer long‐term survival in both patients with localized CRC and those with liver metastasis. NLR is a useful biomarker in delineating those patients with poorer prognosis and whom may benefit from adjuvant therapies.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.24523</identifier><identifier>PMID: 28105646</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Blood Cell Count ; Colorectal cancer ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Humans ; Liver Neoplasms - blood ; Liver Neoplasms - secondary ; Lymphocytes - metabolism ; Medical prognosis ; Metastasis ; Neutrophils ; Neutrophils - metabolism ; neutrophil‐to‐lymphocyte ratio ; Preoperative Period ; Prognosis ; surgical outcomes ; survival</subject><ispartof>Journal of surgical oncology, 2017-03, Vol.115 (4), p.470-479</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4193-b5810025b3c11b19a2fe9bbb27aafa3ed322ecc7dd16d54b857b9800f799cf583</citedby><cites>FETCH-LOGICAL-c4193-b5810025b3c11b19a2fe9bbb27aafa3ed322ecc7dd16d54b857b9800f799cf583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.24523$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.24523$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28105646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haram, Abdelhamed</creatorcontrib><creatorcontrib>Boland, Michael R.</creatorcontrib><creatorcontrib>Kelly, Michael E.</creatorcontrib><creatorcontrib>Bolger, Jarlath C.</creatorcontrib><creatorcontrib>Waldron, Ronan M.</creatorcontrib><creatorcontrib>Kerin, Michael J.</creatorcontrib><title>The prognostic value of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review</title><title>Journal of surgical oncology</title><addtitle>J Surg Oncol</addtitle><description>BACKGROUND AND OBJECTIVES
The detection of a simple and reliable prognostic biomarker for colorectal cancer (CRC) outcomes remains a significant challenge. The use of neutrophil‐to‐lymphocyte ratio (NLR), has been reported to predict surgical and survival outcomes. The aim of our review was to assess the predictive value of pre‐operative NLR in predicting post‐operative outcomes in CRC.
METHODS
A systematic review of the available studies on NLR in CRC was performed. Primarily, we assessed its ability to predict survival outcomes, and highlight values that would help adjuvant therapy choices.
RESULTS
19 studies comprising 10 259 patients were included. Eleven and eight studies reported on patients with localized CRC and colorectal liver metastasis, respectively. Five‐year survival for those with localized CRC was 77.2% in patients with a “low” pre‐operative NLR versus 50.8% in those with a “high” pre‐operative NLR value. Alternatively, for patients with colorectal liver metastasis, patients with a “high” pre‐operative NLR value had a 5‐year survival of 27%.
CONCLUSION
Elevated pre‐operative NLR>5 is associated with poorer long‐term survival in both patients with localized CRC and those with liver metastasis. NLR is a useful biomarker in delineating those patients with poorer prognosis and whom may benefit from adjuvant therapies.</description><subject>Blood Cell Count</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Humans</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - secondary</subject><subject>Lymphocytes - metabolism</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neutrophils</subject><subject>Neutrophils - metabolism</subject><subject>neutrophil‐to‐lymphocyte ratio</subject><subject>Preoperative Period</subject><subject>Prognosis</subject><subject>surgical outcomes</subject><subject>survival</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUhi0EoqUw8ALIEgsMobZzs9kQ4iokBmCObOeEpnLiYiegbDwCz8iT4NLCgMRyznA-ffrPj9A-JSeUEDade3vCkpTFG2hMicgiQQTfRONwY1GSCzJCO97PCSFCZMk2GjFOSZol2RiVjzPAC2efW-u7WuNXaXrAtsIt9J2zi1ltPt8_OhuGGZrFzOqhA-xkV1tct1hbYx3oThqsZavBneIz7AffQSOXOgevNbztoq1KGg976z1BT5cXj-fX0d391c352V2kEyriSKV8-U6qYk2pokKyCoRSiuVSVjKGMmYMtM7LkmZlmiie5kpwQqpcCF2lPJ6go5U3PPTSg--KpvYajJEt2N4XlGc05bngWUAP_6Bz27s2pAuUIHEokC-FxytKO-u9g6pYuLqRbigoKZZZi1B98V19YA_Wxl41UP6SP10HYLoC3moDw_-m4vbhfqX8Ar3NkHE</recordid><startdate>20170315</startdate><enddate>20170315</enddate><creator>Haram, Abdelhamed</creator><creator>Boland, Michael R.</creator><creator>Kelly, Michael E.</creator><creator>Bolger, Jarlath C.</creator><creator>Waldron, Ronan M.</creator><creator>Kerin, Michael J.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20170315</creationdate><title>The prognostic value of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review</title><author>Haram, Abdelhamed ; Boland, Michael R. ; Kelly, Michael E. ; Bolger, Jarlath C. ; Waldron, Ronan M. ; Kerin, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4193-b5810025b3c11b19a2fe9bbb27aafa3ed322ecc7dd16d54b857b9800f799cf583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood Cell Count</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Humans</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - secondary</topic><topic>Lymphocytes - metabolism</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Neutrophils</topic><topic>Neutrophils - metabolism</topic><topic>neutrophil‐to‐lymphocyte ratio</topic><topic>Preoperative Period</topic><topic>Prognosis</topic><topic>surgical outcomes</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haram, Abdelhamed</creatorcontrib><creatorcontrib>Boland, Michael R.</creatorcontrib><creatorcontrib>Kelly, Michael E.</creatorcontrib><creatorcontrib>Bolger, Jarlath C.</creatorcontrib><creatorcontrib>Waldron, Ronan M.</creatorcontrib><creatorcontrib>Kerin, Michael J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haram, Abdelhamed</au><au>Boland, Michael R.</au><au>Kelly, Michael E.</au><au>Bolger, Jarlath C.</au><au>Waldron, Ronan M.</au><au>Kerin, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic value of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J Surg Oncol</addtitle><date>2017-03-15</date><risdate>2017</risdate><volume>115</volume><issue>4</issue><spage>470</spage><epage>479</epage><pages>470-479</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>BACKGROUND AND OBJECTIVES
The detection of a simple and reliable prognostic biomarker for colorectal cancer (CRC) outcomes remains a significant challenge. The use of neutrophil‐to‐lymphocyte ratio (NLR), has been reported to predict surgical and survival outcomes. The aim of our review was to assess the predictive value of pre‐operative NLR in predicting post‐operative outcomes in CRC.
METHODS
A systematic review of the available studies on NLR in CRC was performed. Primarily, we assessed its ability to predict survival outcomes, and highlight values that would help adjuvant therapy choices.
RESULTS
19 studies comprising 10 259 patients were included. Eleven and eight studies reported on patients with localized CRC and colorectal liver metastasis, respectively. Five‐year survival for those with localized CRC was 77.2% in patients with a “low” pre‐operative NLR versus 50.8% in those with a “high” pre‐operative NLR value. Alternatively, for patients with colorectal liver metastasis, patients with a “high” pre‐operative NLR value had a 5‐year survival of 27%.
CONCLUSION
Elevated pre‐operative NLR>5 is associated with poorer long‐term survival in both patients with localized CRC and those with liver metastasis. NLR is a useful biomarker in delineating those patients with poorer prognosis and whom may benefit from adjuvant therapies.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28105646</pmid><doi>10.1002/jso.24523</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Blood Cell Count Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Humans Liver Neoplasms - blood Liver Neoplasms - secondary Lymphocytes - metabolism Medical prognosis Metastasis Neutrophils Neutrophils - metabolism neutrophil‐to‐lymphocyte ratio Preoperative Period Prognosis surgical outcomes survival |
| title | The prognostic value of neutrophil‐to‐lymphocyte ratio in colorectal cancer: A systematic review |
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