Optimal glycemic target level for colon cancer patients with diabetes
Abstract Aims The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes Methods A total of 741 patients with colon cancer between April 1999 and Decemb...
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| Veröffentlicht in: | Diabetes research and clinical practice 2017-02, Vol.124, p.66-71 |
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| container_title | Diabetes research and clinical practice |
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| creator | Jun Lee, Shin Hyun Kim, Jae Ja Park, Seun Young Ock, So Kyoung Kwon, Su Sik Choi, Young Kyung Kim, Bu |
| description | Abstract Aims The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes Methods A total of 741 patients with colon cancer between April 1999 and December 2010 were reviewed. The non-diabetes group had a fasting plasma glucose |
| doi_str_mv | 10.1016/j.diabres.2016.12.009 |
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The non-diabetes group had a fasting plasma glucose <126mg/dL, and the diabetes group had a fasting plasma glucose ⩾126mg/dL. Patients with diabetes were further divided based on glycemic control into either the uncontrolled subgroup (HbA1c ⩾8%) or the well-controlled subgroup(HbA1c <8%). Results Patients with diabetes had significantly shorter overall survival and median survival than non-diabetes patients. Uncontrolled diabetes patients had significantly shorter overall survival and median survival than well-controlled diabetes patients. The relative risk of mortality for diabetes patients was higher than non- diabetes patients (relative risk 1.17). The relative risk of mortality in uncontrolled diabetes patients was significantly higher than in well-controlled diabetes patients (relative risk 4.58). The area under the curve for mortality and HbA1c level was 0.73. The cut off HbA1c level was 7.75%. Conclusions A optimal glycemic control level for colon cancer patients with diabetes should be recommended as an HbA1c of 7.8% or below.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2016.12.009</identifier><identifier>PMID: 28107755</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Aged ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Colon cancer ; Colonic Neoplasms - blood ; Colonic Neoplasms - complications ; Colonic Neoplasms - mortality ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - mortality ; Endocrinology & Metabolism ; Female ; Glucose Tolerance Test ; Glycated Hemoglobin A - analysis ; Glycated Hemoglobin A - metabolism ; Glycemic control ; Goals ; Humans ; Male ; Middle Aged ; Mortality ; Retrospective Studies ; Survival Analysis</subject><ispartof>Diabetes research and clinical practice, 2017-02, Vol.124, p.66-71</ispartof><rights>The Authors</rights><rights>2016 The Authors</rights><rights>Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-8263f888d37e64da128253cd5be7e1ef9ce041a2f2b8bc331cbef0a9a0ee4aca3</citedby><cites>FETCH-LOGICAL-c467t-8263f888d37e64da128253cd5be7e1ef9ce041a2f2b8bc331cbef0a9a0ee4aca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2016.12.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28107755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jun Lee, Shin</creatorcontrib><creatorcontrib>Hyun Kim, Jae</creatorcontrib><creatorcontrib>Ja Park, Seun</creatorcontrib><creatorcontrib>Young Ock, So</creatorcontrib><creatorcontrib>Kyoung Kwon, Su</creatorcontrib><creatorcontrib>Sik Choi, Young</creatorcontrib><creatorcontrib>Kyung Kim, Bu</creatorcontrib><title>Optimal glycemic target level for colon cancer patients with diabetes</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Aims The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes Methods A total of 741 patients with colon cancer between April 1999 and December 2010 were reviewed. The non-diabetes group had a fasting plasma glucose <126mg/dL, and the diabetes group had a fasting plasma glucose ⩾126mg/dL. Patients with diabetes were further divided based on glycemic control into either the uncontrolled subgroup (HbA1c ⩾8%) or the well-controlled subgroup(HbA1c <8%). Results Patients with diabetes had significantly shorter overall survival and median survival than non-diabetes patients. Uncontrolled diabetes patients had significantly shorter overall survival and median survival than well-controlled diabetes patients. The relative risk of mortality for diabetes patients was higher than non- diabetes patients (relative risk 1.17). The relative risk of mortality in uncontrolled diabetes patients was significantly higher than in well-controlled diabetes patients (relative risk 4.58). The area under the curve for mortality and HbA1c level was 0.73. The cut off HbA1c level was 7.75%. Conclusions A optimal glycemic control level for colon cancer patients with diabetes should be recommended as an HbA1c of 7.8% or below.</description><subject>Aged</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - blood</subject><subject>Colonic Neoplasms - complications</subject><subject>Colonic Neoplasms - mortality</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - mortality</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Glycemic control</subject><subject>Goals</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qqLt8_AQqH3vZ4I8kdi6tKkQBCYkDcLacyWTx1ptsbS9o_z1Od9sDF07jkd93Pp4h5JyzgjNeX6yKztk2YCxETgsuCsaaT2TOtRILLYT6TOb5Q_99z8hxjCvGWC3L6guZCc2ZUlU1J1f3m-TW1tOl3wGuHdBkwxIT9fiCnvZjoDD6caBgB8BANzY5HFKkry4902kETBhPyVFvfcSzQzwhT7-uHi9vFnf317eXP-8WUNYq5VFq2WutO6mwLjvLhRaVhK5qUSHHvgFkJbeiF61uQUoOLfbMNpYhlhasPCHf9nU3YfyzxZjM2kVA7-2A4zYarmteaaUbnaXVXgphjDFgbzYhLxp2hjMzETQrcyBoJoKGC5MJZt_XQ4ttu8buv-sfsiz4sRdgXvTFYTARMhLAzgWEZLrRfdji-7sK4N3gwPrfuMO4GrdhyBQNNzEbzMN0xumKvJasbhSTbyvQmkU</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Jun Lee, Shin</creator><creator>Hyun Kim, Jae</creator><creator>Ja Park, Seun</creator><creator>Young Ock, So</creator><creator>Kyoung Kwon, Su</creator><creator>Sik Choi, Young</creator><creator>Kyung Kim, Bu</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>Optimal glycemic target level for colon cancer patients with diabetes</title><author>Jun Lee, Shin ; Hyun Kim, Jae ; Ja Park, Seun ; Young Ock, So ; Kyoung Kwon, Su ; Sik Choi, Young ; Kyung Kim, Bu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-8263f888d37e64da128253cd5be7e1ef9ce041a2f2b8bc331cbef0a9a0ee4aca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - metabolism</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - blood</topic><topic>Colonic Neoplasms - complications</topic><topic>Colonic Neoplasms - mortality</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - mortality</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Glycemic control</topic><topic>Goals</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jun Lee, Shin</creatorcontrib><creatorcontrib>Hyun Kim, Jae</creatorcontrib><creatorcontrib>Ja Park, Seun</creatorcontrib><creatorcontrib>Young Ock, So</creatorcontrib><creatorcontrib>Kyoung Kwon, Su</creatorcontrib><creatorcontrib>Sik Choi, Young</creatorcontrib><creatorcontrib>Kyung Kim, Bu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jun Lee, Shin</au><au>Hyun Kim, Jae</au><au>Ja Park, Seun</au><au>Young Ock, So</au><au>Kyoung Kwon, Su</au><au>Sik Choi, Young</au><au>Kyung Kim, Bu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimal glycemic target level for colon cancer patients with diabetes</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>124</volume><spage>66</spage><epage>71</epage><pages>66-71</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Aims The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes Methods A total of 741 patients with colon cancer between April 1999 and December 2010 were reviewed. The non-diabetes group had a fasting plasma glucose <126mg/dL, and the diabetes group had a fasting plasma glucose ⩾126mg/dL. Patients with diabetes were further divided based on glycemic control into either the uncontrolled subgroup (HbA1c ⩾8%) or the well-controlled subgroup(HbA1c <8%). Results Patients with diabetes had significantly shorter overall survival and median survival than non-diabetes patients. Uncontrolled diabetes patients had significantly shorter overall survival and median survival than well-controlled diabetes patients. The relative risk of mortality for diabetes patients was higher than non- diabetes patients (relative risk 1.17). The relative risk of mortality in uncontrolled diabetes patients was significantly higher than in well-controlled diabetes patients (relative risk 4.58). The area under the curve for mortality and HbA1c level was 0.73. The cut off HbA1c level was 7.75%. Conclusions A optimal glycemic control level for colon cancer patients with diabetes should be recommended as an HbA1c of 7.8% or below.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>28107755</pmid><doi>10.1016/j.diabres.2016.12.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Blood Glucose - analysis Blood Glucose - metabolism Colon cancer Colonic Neoplasms - blood Colonic Neoplasms - complications Colonic Neoplasms - mortality Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - mortality Endocrinology & Metabolism Female Glucose Tolerance Test Glycated Hemoglobin A - analysis Glycated Hemoglobin A - metabolism Glycemic control Goals Humans Male Middle Aged Mortality Retrospective Studies Survival Analysis |
| title | Optimal glycemic target level for colon cancer patients with diabetes |
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