Activity‐based probes for the multicatalytic proteasome

Proteasomes are multisubunit protease complexes responsible for degrading most intracellular proteins. In addition to removing damaged proteins, they regulate many important cellular processes through the controlled degradation of transcription factors, cell cycle regulators, and enzymes. Eukaryotic...

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Veröffentlicht in:	The FEBS journal 2017-05, Vol.284 (10), p.1540-1554
Hauptverfasser:	Hewings, David S., Flygare, John A., Wertz, Ingrid E., Bogyo, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	activity‐based probe activity‐based protein profiling Biological activity Biomonitoring Catalytic subunits Cell cycle covalent inhibitor Degradation Drugs Enzymes Hematology Inhibitors Peptide Hydrolases - metabolism Probes Protease Protease inhibitors Proteases proteasome proteasome inhibitor Proteasome inhibitors Proteasome Inhibitors - pharmacology Proteasomes Proteinase Proteinase inhibitors Proteins Proteolysis Substrate inhibition Substrate Specificity Tissues Transcription factors
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