Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study
Objective To investigate the value of ‘swallow-tail’ sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson’s disease (IPD). Methods Three groups – 39 MSA patients, 18 IPD patients,and 31 healthy contro...
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| Veröffentlicht in: | European radiology 2017-08, Vol.27 (8), p.3174-3180 |
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| creator | Wang, Na Yang, HuaGuang Li, ChengBo Fan, GuoGuang Luo, XiaoGuang |
| description | Objective
To investigate the value of ‘swallow-tail’ sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson’s disease (IPD).
Methods
Three groups – 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) – were administered a 3 T SWI sequence to evaluate ‘swallow-tail’ sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively. The diagnostic accuracy of the two signs separately and combined was calculated using a receiver operating characteristic curve, with clinical diagnosis as the gold standard.
Results
The scores of ‘swallow-tail’ sign were lower in IPD than in MSA or in HCs, as well as for putaminal hypointensity in IPD or HCs than in MSA (p |
| doi_str_mv | 10.1007/s00330-017-4743-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1861586473</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861586473</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-eac593598fcc769c73b13e7e392381521624b5966c05c931d27657b369fc3f903</originalsourceid><addsrcrecordid>eNp1kU1u1TAUhS0Eoo_CApggS0yYGOw4iWNmVVV-pEowoOPIcZw8F8cOvo5eM-syYDFspivB0SsIITHywN855957EHrO6GtGqXgDlHJOCWWClKLk5OYB2rGSF4TRpnyIdlTyhggpyxP0BOCaUipZKR6jk6JhtKoo36GfV2D9iO9uv8NBORcOJCnr7m5_YLCjx8r3eF6SmqxXDu_XOVifjAebVqwAdzZMKn41EXAKuLeQstliYY-nxSU7O4NhhWQmrFIM837FQwwTtr0Ns0p7q_HnLLcegs-RsDkYBeYtPsOwgDZzsp11OYwcjB33yfTYTmrcJoa09OtT9GhQDsyz-_cUXb27-HL-gVx-ev_x_OyS6JI3iRilK8kr2Qxai1pqwTvGjTBcFrxhVcHqouwqWdeaVlpy1heirkTHazloPkjKT9Gro-8cw7fFQGonm8dzTnkTFmhZU7OqqUvBM_ryH_Q6LDFfL1Pb9UXujGWKHSkdA0A0QzvHvFlcW0bbrdv22G2bu223btubrHlx77x0k-n_KH6XmYHiCED-8qOJf0X_1_UXk7S26w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1914770031</pqid></control><display><type>article</type><title>Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Na ; Yang, HuaGuang ; Li, ChengBo ; Fan, GuoGuang ; Luo, XiaoGuang</creator><creatorcontrib>Wang, Na ; Yang, HuaGuang ; Li, ChengBo ; Fan, GuoGuang ; Luo, XiaoGuang</creatorcontrib><description>Objective
To investigate the value of ‘swallow-tail’ sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson’s disease (IPD).
Methods
Three groups – 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) – were administered a 3 T SWI sequence to evaluate ‘swallow-tail’ sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively. The diagnostic accuracy of the two signs separately and combined was calculated using a receiver operating characteristic curve, with clinical diagnosis as the gold standard.
Results
The scores of ‘swallow-tail’ sign were lower in IPD than in MSA or in HCs, as well as for putaminal hypointensity in IPD or HCs than in MSA (p < 0.05). The sensitivity and specificity of ‘swallow-tail’ sign and putaminal hypointensity were 87.9% and 83.3%, and 35.9% and 100%, respectively, in the respective patient groups. The area under the curve of combined signs was increased from 0.85 (‘swallow tail’) or 0.68 (putaminal hypointensity) to 0.93.
Conclusion
The combination of ‘swallow-tail’ sign and putaminal hypointensity can increase the accuracy of discriminating between MSA and IPD.
Key Points
•
Differential diagnosis of MSA and IPD is still challenging in clinical practice
.
•
Absence of
‘
swallow
-
tail
’
sign is a valuable biomarker for IPD on SWI
.
•
Putaminal hypointensity is a valuable biomarker for MSA on SWI
.
•
Combined
‘
swallow
-
tail
’
sign and putaminal hypointensity increase diagnostic accuracy
.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-017-4743-x</identifier><identifier>PMID: 28105503</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Aged ; Analysis of Variance ; Atrophy ; Biomarkers ; Case-Control Studies ; Diagnosis ; Diagnosis, Differential ; Diagnostic Radiology ; Diagnostic systems ; Differential diagnosis ; Female ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Movement disorders ; Multiple System Atrophy - diagnosis ; Neuro ; Neurodegenerative diseases ; Neuroradiology ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - pathology ; Parkinson's disease ; Patients ; Putamen - diagnostic imaging ; Radiology ; ROC Curve ; Sensitivity and Specificity ; Substantia Nigra - diagnostic imaging ; Tails ; Ultrasound</subject><ispartof>European radiology, 2017-08, Vol.27 (8), p.3174-3180</ispartof><rights>European Society of Radiology 2017</rights><rights>European Radiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-eac593598fcc769c73b13e7e392381521624b5966c05c931d27657b369fc3f903</citedby><cites>FETCH-LOGICAL-c438t-eac593598fcc769c73b13e7e392381521624b5966c05c931d27657b369fc3f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-017-4743-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-017-4743-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28105503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Yang, HuaGuang</creatorcontrib><creatorcontrib>Li, ChengBo</creatorcontrib><creatorcontrib>Fan, GuoGuang</creatorcontrib><creatorcontrib>Luo, XiaoGuang</creatorcontrib><title>Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To investigate the value of ‘swallow-tail’ sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson’s disease (IPD).
Methods
Three groups – 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) – were administered a 3 T SWI sequence to evaluate ‘swallow-tail’ sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively. The diagnostic accuracy of the two signs separately and combined was calculated using a receiver operating characteristic curve, with clinical diagnosis as the gold standard.
Results
The scores of ‘swallow-tail’ sign were lower in IPD than in MSA or in HCs, as well as for putaminal hypointensity in IPD or HCs than in MSA (p < 0.05). The sensitivity and specificity of ‘swallow-tail’ sign and putaminal hypointensity were 87.9% and 83.3%, and 35.9% and 100%, respectively, in the respective patient groups. The area under the curve of combined signs was increased from 0.85 (‘swallow tail’) or 0.68 (putaminal hypointensity) to 0.93.
Conclusion
The combination of ‘swallow-tail’ sign and putaminal hypointensity can increase the accuracy of discriminating between MSA and IPD.
Key Points
•
Differential diagnosis of MSA and IPD is still challenging in clinical practice
.
•
Absence of
‘
swallow
-
tail
’
sign is a valuable biomarker for IPD on SWI
.
•
Putaminal hypointensity is a valuable biomarker for MSA on SWI
.
•
Combined
‘
swallow
-
tail
’
sign and putaminal hypointensity increase diagnostic accuracy
.</description><subject>Accuracy</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Atrophy</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Radiology</subject><subject>Diagnostic systems</subject><subject>Differential diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Multiple System Atrophy - diagnosis</subject><subject>Neuro</subject><subject>Neurodegenerative diseases</subject><subject>Neuroradiology</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Putamen - diagnostic imaging</subject><subject>Radiology</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Substantia Nigra - diagnostic imaging</subject><subject>Tails</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU1u1TAUhS0Eoo_CApggS0yYGOw4iWNmVVV-pEowoOPIcZw8F8cOvo5eM-syYDFspivB0SsIITHywN855957EHrO6GtGqXgDlHJOCWWClKLk5OYB2rGSF4TRpnyIdlTyhggpyxP0BOCaUipZKR6jk6JhtKoo36GfV2D9iO9uv8NBORcOJCnr7m5_YLCjx8r3eF6SmqxXDu_XOVifjAebVqwAdzZMKn41EXAKuLeQstliYY-nxSU7O4NhhWQmrFIM837FQwwTtr0Ns0p7q_HnLLcegs-RsDkYBeYtPsOwgDZzsp11OYwcjB33yfTYTmrcJoa09OtT9GhQDsyz-_cUXb27-HL-gVx-ev_x_OyS6JI3iRilK8kr2Qxai1pqwTvGjTBcFrxhVcHqouwqWdeaVlpy1heirkTHazloPkjKT9Gro-8cw7fFQGonm8dzTnkTFmhZU7OqqUvBM_ryH_Q6LDFfL1Pb9UXujGWKHSkdA0A0QzvHvFlcW0bbrdv22G2bu223btubrHlx77x0k-n_KH6XmYHiCED-8qOJf0X_1_UXk7S26w</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Wang, Na</creator><creator>Yang, HuaGuang</creator><creator>Li, ChengBo</creator><creator>Fan, GuoGuang</creator><creator>Luo, XiaoGuang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study</title><author>Wang, Na ; Yang, HuaGuang ; Li, ChengBo ; Fan, GuoGuang ; Luo, XiaoGuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-eac593598fcc769c73b13e7e392381521624b5966c05c931d27657b369fc3f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accuracy</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Atrophy</topic><topic>Biomarkers</topic><topic>Case-Control Studies</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Radiology</topic><topic>Diagnostic systems</topic><topic>Differential diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Multiple System Atrophy - diagnosis</topic><topic>Neuro</topic><topic>Neurodegenerative diseases</topic><topic>Neuroradiology</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Putamen - diagnostic imaging</topic><topic>Radiology</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Substantia Nigra - diagnostic imaging</topic><topic>Tails</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Na</creatorcontrib><creatorcontrib>Yang, HuaGuang</creatorcontrib><creatorcontrib>Li, ChengBo</creatorcontrib><creatorcontrib>Fan, GuoGuang</creatorcontrib><creatorcontrib>Luo, XiaoGuang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Na</au><au>Yang, HuaGuang</au><au>Li, ChengBo</au><au>Fan, GuoGuang</au><au>Luo, XiaoGuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>27</volume><issue>8</issue><spage>3174</spage><epage>3180</epage><pages>3174-3180</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To investigate the value of ‘swallow-tail’ sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson’s disease (IPD).
Methods
Three groups – 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) – were administered a 3 T SWI sequence to evaluate ‘swallow-tail’ sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively. The diagnostic accuracy of the two signs separately and combined was calculated using a receiver operating characteristic curve, with clinical diagnosis as the gold standard.
Results
The scores of ‘swallow-tail’ sign were lower in IPD than in MSA or in HCs, as well as for putaminal hypointensity in IPD or HCs than in MSA (p < 0.05). The sensitivity and specificity of ‘swallow-tail’ sign and putaminal hypointensity were 87.9% and 83.3%, and 35.9% and 100%, respectively, in the respective patient groups. The area under the curve of combined signs was increased from 0.85 (‘swallow tail’) or 0.68 (putaminal hypointensity) to 0.93.
Conclusion
The combination of ‘swallow-tail’ sign and putaminal hypointensity can increase the accuracy of discriminating between MSA and IPD.
Key Points
•
Differential diagnosis of MSA and IPD is still challenging in clinical practice
.
•
Absence of
‘
swallow
-
tail
’
sign is a valuable biomarker for IPD on SWI
.
•
Putaminal hypointensity is a valuable biomarker for MSA on SWI
.
•
Combined
‘
swallow
-
tail
’
sign and putaminal hypointensity increase diagnostic accuracy
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28105503</pmid><doi>10.1007/s00330-017-4743-x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2017-08, Vol.27 (8), p.3174-3180 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1861586473 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Accuracy Aged Analysis of Variance Atrophy Biomarkers Case-Control Studies Diagnosis Diagnosis, Differential Diagnostic Radiology Diagnostic systems Differential diagnosis Female Humans Imaging Internal Medicine Interventional Radiology Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Middle Aged Movement disorders Multiple System Atrophy - diagnosis Neuro Neurodegenerative diseases Neuroradiology Parkinson Disease - diagnostic imaging Parkinson Disease - pathology Parkinson's disease Patients Putamen - diagnostic imaging Radiology ROC Curve Sensitivity and Specificity Substantia Nigra - diagnostic imaging Tails Ultrasound |
| title | Using ‘swallow-tail’ sign and putaminal hypointensity as biomarkers to distinguish multiple system atrophy from idiopathic Parkinson’s disease: A susceptibility-weighted imaging study |
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