A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years
Purpose Autologous Matrix-Induced Chondrogenesis (AMIC ® ) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years. Methods Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm 2 ) were...
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| Veröffentlicht in: | International orthopaedics 2017-04, Vol.41 (4), p.797-804 |
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| creator | Volz, Martin Schaumburger, Jens Frick, Hubert Grifka, Joachim Anders, Sven |
| description | Purpose
Autologous Matrix-Induced Chondrogenesis (AMIC
®
) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.
Methods
Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm
2
) were randomized and treated either with MFx, with sutured or glued AMIC
®
in a prospective multicentre clinical trial.
Results
After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC
®
groups. At two and five years, MRI defect filling was more complete in the AMIC
®
groups. No treatment-related adverse events were reported.
Conclusions
AMIC
®
is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years. |
| doi_str_mv | 10.1007/s00264-016-3391-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1861585226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861585226</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-332793e25d3309717cd0d2f76e53b56351da7db75d1d2f5fc8ba82f33da832353</originalsourceid><addsrcrecordid>eNp9kcFuFSEUhomxsdfqA7gxLN2McuAyMMubG6tNarqpa8IMhyvNDFRgGusr-BI-S59MmltduoJwvv_P-fkJeQPsPTCmPhTGeL_tGPSdEAN07BnZwFbwTsIgn5MNE1voeD_IU_KylBvGQPUaXpBTroFppdSG_NrRbKNLS_iJjk4p1pzmuV1rDnamDpcUS822hnigZS3VhtimI0b0odLk6W6taU6HtBb6xTbVj-4iunVq0P5bii6nQ2NLKDTdYaZLmHLy2U51zUhtpT7c4cPve7S5vCIn3s4FXz-dZ-Tr-cfr_efu8urTxX532U1Cq9qicjUI5NIJwQYFanLMca96lGKUvZDgrHKjkg7as_STHq3mXghnteBCijPy7uh7m9P3FUs1SygTzrON2GIY0D1ILTnvGwpHtG1dSkZvbnNYbL43wMxjB-bYgWkdmMcODGuat0_267ig-6f4--kN4EegtFE8YDY3ac2xRf6P6x99gpW_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1861585226</pqid></control><display><type>article</type><title>A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Volz, Martin ; Schaumburger, Jens ; Frick, Hubert ; Grifka, Joachim ; Anders, Sven</creator><creatorcontrib>Volz, Martin ; Schaumburger, Jens ; Frick, Hubert ; Grifka, Joachim ; Anders, Sven</creatorcontrib><description>Purpose
Autologous Matrix-Induced Chondrogenesis (AMIC
®
) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.
Methods
Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm
2
) were randomized and treated either with MFx, with sutured or glued AMIC
®
in a prospective multicentre clinical trial.
Results
After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC
®
groups. At two and five years, MRI defect filling was more complete in the AMIC
®
groups. No treatment-related adverse events were reported.
Conclusions
AMIC
®
is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years.</description><identifier>ISSN: 0341-2695</identifier><identifier>EISSN: 1432-5195</identifier><identifier>DOI: 10.1007/s00264-016-3391-0</identifier><identifier>PMID: 28108777</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Arthroplasty, Subchondral - rehabilitation ; Cartilage Diseases - diagnostic imaging ; Cartilage Diseases - surgery ; Cartilage, Articular - diagnostic imaging ; Cartilage, Articular - surgery ; Chondrogenesis ; Female ; Follow-Up Studies ; Humans ; Knee Joint - diagnostic imaging ; Knee Joint - surgery ; Magnetic Resonance Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Paper ; Orthopedics ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - surgery ; Prospective Studies ; Transplantation, Autologous - rehabilitation ; Treatment Outcome ; Young Adult</subject><ispartof>International orthopaedics, 2017-04, Vol.41 (4), p.797-804</ispartof><rights>The Author(s) 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-332793e25d3309717cd0d2f76e53b56351da7db75d1d2f5fc8ba82f33da832353</citedby><cites>FETCH-LOGICAL-c387t-332793e25d3309717cd0d2f76e53b56351da7db75d1d2f5fc8ba82f33da832353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00264-016-3391-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00264-016-3391-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28108777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Volz, Martin</creatorcontrib><creatorcontrib>Schaumburger, Jens</creatorcontrib><creatorcontrib>Frick, Hubert</creatorcontrib><creatorcontrib>Grifka, Joachim</creatorcontrib><creatorcontrib>Anders, Sven</creatorcontrib><title>A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years</title><title>International orthopaedics</title><addtitle>International Orthopaedics (SICOT)</addtitle><addtitle>Int Orthop</addtitle><description>Purpose
Autologous Matrix-Induced Chondrogenesis (AMIC
®
) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.
Methods
Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm
2
) were randomized and treated either with MFx, with sutured or glued AMIC
®
in a prospective multicentre clinical trial.
Results
After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC
®
groups. At two and five years, MRI defect filling was more complete in the AMIC
®
groups. No treatment-related adverse events were reported.
Conclusions
AMIC
®
is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years.</description><subject>Adult</subject><subject>Arthroplasty, Subchondral - rehabilitation</subject><subject>Cartilage Diseases - diagnostic imaging</subject><subject>Cartilage Diseases - surgery</subject><subject>Cartilage, Articular - diagnostic imaging</subject><subject>Cartilage, Articular - surgery</subject><subject>Chondrogenesis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Knee Joint - diagnostic imaging</subject><subject>Knee Joint - surgery</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Orthopedics</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Prospective Studies</subject><subject>Transplantation, Autologous - rehabilitation</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0341-2695</issn><issn>1432-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcFuFSEUhomxsdfqA7gxLN2McuAyMMubG6tNarqpa8IMhyvNDFRgGusr-BI-S59MmltduoJwvv_P-fkJeQPsPTCmPhTGeL_tGPSdEAN07BnZwFbwTsIgn5MNE1voeD_IU_KylBvGQPUaXpBTroFppdSG_NrRbKNLS_iJjk4p1pzmuV1rDnamDpcUS822hnigZS3VhtimI0b0odLk6W6taU6HtBb6xTbVj-4iunVq0P5bii6nQ2NLKDTdYaZLmHLy2U51zUhtpT7c4cPve7S5vCIn3s4FXz-dZ-Tr-cfr_efu8urTxX532U1Cq9qicjUI5NIJwQYFanLMca96lGKUvZDgrHKjkg7as_STHq3mXghnteBCijPy7uh7m9P3FUs1SygTzrON2GIY0D1ILTnvGwpHtG1dSkZvbnNYbL43wMxjB-bYgWkdmMcODGuat0_267ig-6f4--kN4EegtFE8YDY3ac2xRf6P6x99gpW_</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Volz, Martin</creator><creator>Schaumburger, Jens</creator><creator>Frick, Hubert</creator><creator>Grifka, Joachim</creator><creator>Anders, Sven</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years</title><author>Volz, Martin ; Schaumburger, Jens ; Frick, Hubert ; Grifka, Joachim ; Anders, Sven</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-332793e25d3309717cd0d2f76e53b56351da7db75d1d2f5fc8ba82f33da832353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Arthroplasty, Subchondral - rehabilitation</topic><topic>Cartilage Diseases - diagnostic imaging</topic><topic>Cartilage Diseases - surgery</topic><topic>Cartilage, Articular - diagnostic imaging</topic><topic>Cartilage, Articular - surgery</topic><topic>Chondrogenesis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Knee Joint - diagnostic imaging</topic><topic>Knee Joint - surgery</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Orthopedics</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Prospective Studies</topic><topic>Transplantation, Autologous - rehabilitation</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Volz, Martin</creatorcontrib><creatorcontrib>Schaumburger, Jens</creatorcontrib><creatorcontrib>Frick, Hubert</creatorcontrib><creatorcontrib>Grifka, Joachim</creatorcontrib><creatorcontrib>Anders, Sven</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Volz, Martin</au><au>Schaumburger, Jens</au><au>Frick, Hubert</au><au>Grifka, Joachim</au><au>Anders, Sven</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years</atitle><jtitle>International orthopaedics</jtitle><stitle>International Orthopaedics (SICOT)</stitle><addtitle>Int Orthop</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>41</volume><issue>4</issue><spage>797</spage><epage>804</epage><pages>797-804</pages><issn>0341-2695</issn><eissn>1432-5195</eissn><abstract>Purpose
Autologous Matrix-Induced Chondrogenesis (AMIC
®
) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years.
Methods
Forty-seven patients (aged 37 ± 10 years, mean defect size 3.6 ± 1.6 cm
2
) were randomized and treated either with MFx, with sutured or glued AMIC
®
in a prospective multicentre clinical trial.
Results
After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC
®
groups. At two and five years, MRI defect filling was more complete in the AMIC
®
groups. No treatment-related adverse events were reported.
Conclusions
AMIC
®
is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28108777</pmid><doi>10.1007/s00264-016-3391-0</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International orthopaedics, 2017-04, Vol.41 (4), p.797-804 |
| issn | 0341-2695 1432-5195 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Adult Arthroplasty, Subchondral - rehabilitation Cartilage Diseases - diagnostic imaging Cartilage Diseases - surgery Cartilage, Articular - diagnostic imaging Cartilage, Articular - surgery Chondrogenesis Female Follow-Up Studies Humans Knee Joint - diagnostic imaging Knee Joint - surgery Magnetic Resonance Imaging Male Medicine Medicine & Public Health Middle Aged Original Paper Orthopedics Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - surgery Prospective Studies Transplantation, Autologous - rehabilitation Treatment Outcome Young Adult |
| title | A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years |
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