Use of the channel fill level in defining a design space for twin screw wet granulation

[Display omitted] Twin screw wet granulation is a key process in the continuous manufacture of oral solid dosage forms. Previous research has qualitatively suggested that the channel fill level influences the granules produced. In this paper a quantitative measure of the total volumetric fraction of...

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Veröffentlicht in:	International journal of pharmaceutics 2017-03, Vol.519 (1-2), p.165-177
Hauptverfasser:	Gorringe, L.J., Kee, G.S., Saleh, M.F., Fa, N.H., Elkes, R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Channel fill Continuous manufacturing Design space Dosage Forms Particle Size Powders - chemistry Residence time Technology, Pharmaceutical - methods Twin screw granulation
Online-Zugang:	Volltext
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