Prediction of Pan‐Specific B‐Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome
ABSTRACT Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG‐based serological detection methods are the most common approaches used f...
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| Veröffentlicht in: | Journal of cellular biochemistry 2017-08, Vol.118 (8), p.2320-2324 |
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| container_title | Journal of cellular biochemistry |
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| creator | Kalaiselvan, Sagadevan Sankar, Sathish Ramamurthy, Mageshbabu Ghosh, Asit Ranjan Nandagopal, Balaji Sridharan, Gopalan |
| description | ABSTRACT
Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG‐based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan‐specific epitopes of genotypes. We predicted linear B‐cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers. We modeled the Andes and Sin Nombre hantavirus nucleocapsid protein to locate the identified epitopes. Based on the mean percent prediction probability score, epitope IMASKSVGS/TAEEKLKKKSAF was identified as the best candidate B‐cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified in the C‐terminal of the protein. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools toward pan‐detection of hantavirus antibodies in ELISA. J. Cell. Biochem. 118: 2320–2324, 2017. © 2017 Wiley Periodicals, Inc.
Hantaviruses causes severe, respiratory disease in humans with high case fatality rate. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools towards pan‐detection of hantavirus antibodies in ELISA. |
| doi_str_mv | 10.1002/jcb.25887 |
| format | Article |
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Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG‐based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan‐specific epitopes of genotypes. We predicted linear B‐cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers. We modeled the Andes and Sin Nombre hantavirus nucleocapsid protein to locate the identified epitopes. Based on the mean percent prediction probability score, epitope IMASKSVGS/TAEEKLKKKSAF was identified as the best candidate B‐cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified in the C‐terminal of the protein. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools toward pan‐detection of hantavirus antibodies in ELISA. J. Cell. Biochem. 118: 2320–2324, 2017. © 2017 Wiley Periodicals, Inc.
Hantaviruses causes severe, respiratory disease in humans with high case fatality rate. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools towards pan‐detection of hantavirus antibodies in ELISA.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.25887</identifier><identifier>PMID: 28106282</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Antibodies ; B CELL EPITOPES ; BIOINFORMATICS ; Diagnostic systems ; Enzyme-linked immunosorbent assay ; Epitopes ; Epitopes, B-Lymphocyte - chemistry ; Epitopes, B-Lymphocyte - immunology ; Genotype ; Genotypes ; Hantavirus ; Hantavirus - immunology ; Hantavirus - pathogenicity ; Hantavirus Infections - immunology ; Hantavirus Infections - metabolism ; Hantavirus Pulmonary Syndrome - immunology ; Hantavirus Pulmonary Syndrome - metabolism ; HANTAVIRUSES ; HCPS ; Humans ; Immunoassay ; Immunoassays ; Immunoglobulin G ; Immunoglobulin M ; Lymphocytes B ; NUCLEOCAPSID ; Nucleocapsid Proteins - chemistry ; Nucleocapsid Proteins - immunology ; Nucleocapsids ; Pathogens ; Predictions ; Protein Structure, Secondary ; Proteins ; Respiratory diseases ; Vaccines</subject><ispartof>Journal of cellular biochemistry, 2017-08, Vol.118 (8), p.2320-2324</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3197-5c5aa44d4bdc0ff4772ef9d9e2dbec9558d0c16bd19c72d6d1b3f061cd4eb0ff3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.25887$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.25887$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28106282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalaiselvan, Sagadevan</creatorcontrib><creatorcontrib>Sankar, Sathish</creatorcontrib><creatorcontrib>Ramamurthy, Mageshbabu</creatorcontrib><creatorcontrib>Ghosh, Asit Ranjan</creatorcontrib><creatorcontrib>Nandagopal, Balaji</creatorcontrib><creatorcontrib>Sridharan, Gopalan</creatorcontrib><title>Prediction of Pan‐Specific B‐Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>ABSTRACT
Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG‐based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan‐specific epitopes of genotypes. We predicted linear B‐cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers. We modeled the Andes and Sin Nombre hantavirus nucleocapsid protein to locate the identified epitopes. Based on the mean percent prediction probability score, epitope IMASKSVGS/TAEEKLKKKSAF was identified as the best candidate B‐cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified in the C‐terminal of the protein. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools toward pan‐detection of hantavirus antibodies in ELISA. J. Cell. Biochem. 118: 2320–2324, 2017. © 2017 Wiley Periodicals, Inc.
Hantaviruses causes severe, respiratory disease in humans with high case fatality rate. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools towards pan‐detection of hantavirus antibodies in ELISA.</description><subject>Antibodies</subject><subject>B CELL EPITOPES</subject><subject>BIOINFORMATICS</subject><subject>Diagnostic systems</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epitopes</subject><subject>Epitopes, B-Lymphocyte - chemistry</subject><subject>Epitopes, B-Lymphocyte - immunology</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hantavirus</subject><subject>Hantavirus - immunology</subject><subject>Hantavirus - pathogenicity</subject><subject>Hantavirus Infections - immunology</subject><subject>Hantavirus Infections - metabolism</subject><subject>Hantavirus Pulmonary Syndrome - immunology</subject><subject>Hantavirus Pulmonary Syndrome - metabolism</subject><subject>HANTAVIRUSES</subject><subject>HCPS</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoassays</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Lymphocytes B</subject><subject>NUCLEOCAPSID</subject><subject>Nucleocapsid Proteins - chemistry</subject><subject>Nucleocapsid Proteins - immunology</subject><subject>Nucleocapsids</subject><subject>Pathogens</subject><subject>Predictions</subject><subject>Protein Structure, Secondary</subject><subject>Proteins</subject><subject>Respiratory diseases</subject><subject>Vaccines</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1OwzAQhS0EglJYcAEUiQ2bUv8kTryEqKUgBJWAteXYDnKVxMFOQN2x4ACckZNg2oIQK9vjb57mzQPgCMEzBCEeL2RxhpMsS7fAAEGWjmIax9tgAFMCR5ggvAf2vV9ACBkjeBfs4QxBijM8AO9zp5WRnbFNZMtoLprPt4_7VktTGhldhEeuqyqatKazrfbR1Nk6uu1lpa0UrTcqmjvbabPqnommEy_G9T6Quei9aZ7-FEPJKWPbvqptI9wyul82KujpA7BTisrrw805BI_TyUM-G93cXV7l5zcjSVBwlchEiDhWcaEkLMs4TbEumWIaq0JLliSZghLRQiEmU6yoQgUpIUVSxboIDWQITte6rbPPvfYdr42XwZ9otO09RxlFSUZoCgN68g9d2N41YTqOGKSUMkKzQB1vqL6oteKtM3Uwxn_2G4DxGng1lV7-_iPIv4PjITi-Co5f5xerC_kCX3yO4Q</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Kalaiselvan, Sagadevan</creator><creator>Sankar, Sathish</creator><creator>Ramamurthy, Mageshbabu</creator><creator>Ghosh, Asit Ranjan</creator><creator>Nandagopal, Balaji</creator><creator>Sridharan, Gopalan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201708</creationdate><title>Prediction of Pan‐Specific B‐Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome</title><author>Kalaiselvan, Sagadevan ; Sankar, Sathish ; Ramamurthy, Mageshbabu ; Ghosh, Asit Ranjan ; Nandagopal, Balaji ; Sridharan, Gopalan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3197-5c5aa44d4bdc0ff4772ef9d9e2dbec9558d0c16bd19c72d6d1b3f061cd4eb0ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antibodies</topic><topic>B CELL EPITOPES</topic><topic>BIOINFORMATICS</topic><topic>Diagnostic systems</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epitopes</topic><topic>Epitopes, B-Lymphocyte - chemistry</topic><topic>Epitopes, B-Lymphocyte - immunology</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hantavirus</topic><topic>Hantavirus - immunology</topic><topic>Hantavirus - pathogenicity</topic><topic>Hantavirus Infections - immunology</topic><topic>Hantavirus Infections - metabolism</topic><topic>Hantavirus Pulmonary Syndrome - immunology</topic><topic>Hantavirus Pulmonary Syndrome - metabolism</topic><topic>HANTAVIRUSES</topic><topic>HCPS</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoassays</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin M</topic><topic>Lymphocytes B</topic><topic>NUCLEOCAPSID</topic><topic>Nucleocapsid Proteins - chemistry</topic><topic>Nucleocapsid Proteins - immunology</topic><topic>Nucleocapsids</topic><topic>Pathogens</topic><topic>Predictions</topic><topic>Protein Structure, Secondary</topic><topic>Proteins</topic><topic>Respiratory diseases</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalaiselvan, Sagadevan</creatorcontrib><creatorcontrib>Sankar, Sathish</creatorcontrib><creatorcontrib>Ramamurthy, Mageshbabu</creatorcontrib><creatorcontrib>Ghosh, Asit Ranjan</creatorcontrib><creatorcontrib>Nandagopal, Balaji</creatorcontrib><creatorcontrib>Sridharan, Gopalan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalaiselvan, Sagadevan</au><au>Sankar, Sathish</au><au>Ramamurthy, Mageshbabu</au><au>Ghosh, Asit Ranjan</au><au>Nandagopal, Balaji</au><au>Sridharan, Gopalan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of Pan‐Specific B‐Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2017-08</date><risdate>2017</risdate><volume>118</volume><issue>8</issue><spage>2320</spage><epage>2324</epage><pages>2320-2324</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>ABSTRACT
Hantaviruses are emerging viral pathogens that causes hantavirus cardiopulmonary syndrome (HCPS) in the Americas, a severe, sometimes fatal, respiratory disease in humans with a case fatality rate of ≥50%. IgM and IgG‐based serological detection methods are the most common approaches used for laboratory diagnosis of hantaviruses. Such emerging viral pathogens emphasizes the need for improved rapid diagnostic devices and vaccines incorporating pan‐specific epitopes of genotypes. We predicted linear B‐cell epitopes for hantaviruses that are specific to genotypes causing HCPS in humans using in silico prediction servers. We modeled the Andes and Sin Nombre hantavirus nucleocapsid protein to locate the identified epitopes. Based on the mean percent prediction probability score, epitope IMASKSVGS/TAEEKLKKKSAF was identified as the best candidate B‐cell epitope specific for hantaviruses causing HCPS. Promiscuous epitopes were identified in the C‐terminal of the protein. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools toward pan‐detection of hantavirus antibodies in ELISA. J. Cell. Biochem. 118: 2320–2324, 2017. © 2017 Wiley Periodicals, Inc.
Hantaviruses causes severe, respiratory disease in humans with high case fatality rate. Our study for the first time has reported pan‐specific B‐cell epitopes for developing immunoassays in the detection of antibodies to hantaviruses causing HCPS. Identification of epitopes with pan‐specific recognition of all genotypes causing HCPS could be valuable for the development of immunodiagnositic tools towards pan‐detection of hantavirus antibodies in ELISA.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28106282</pmid><doi>10.1002/jcb.25887</doi><tpages>5</tpages></addata></record> |
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| subjects | Antibodies B CELL EPITOPES BIOINFORMATICS Diagnostic systems Enzyme-linked immunosorbent assay Epitopes Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Genotype Genotypes Hantavirus Hantavirus - immunology Hantavirus - pathogenicity Hantavirus Infections - immunology Hantavirus Infections - metabolism Hantavirus Pulmonary Syndrome - immunology Hantavirus Pulmonary Syndrome - metabolism HANTAVIRUSES HCPS Humans Immunoassay Immunoassays Immunoglobulin G Immunoglobulin M Lymphocytes B NUCLEOCAPSID Nucleocapsid Proteins - chemistry Nucleocapsid Proteins - immunology Nucleocapsids Pathogens Predictions Protein Structure, Secondary Proteins Respiratory diseases Vaccines |
| title | Prediction of Pan‐Specific B‐Cell Epitopes From Nucleocapsid Protein of Hantaviruses Causing Hantavirus Cardiopulmonary Syndrome |
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