Histamine Applied Topically to the Nasal Mucosa Increases the Transmucosal Nitrous Oxide Exchange for the Middle Ear

Objective: Determine if the middle ear transmucosal nitrous oxide (N2O) exchange rate is affected by nasal inflammation caused by topical application of histamine. Methods: In a randomized, double-blind, crossover study, 20 adults were challenged intranasally with histamine (5 mg) and placebo on sep...

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Veröffentlicht in:	Annals of otology, rhinology & laryngology rhinology & laryngology, 2017-04, Vol.126 (4), p.284-289
Hauptverfasser:	Teixeira, Miriam S., Alper, Cuneyt M., Martin, Brian S., Cetin, Selma, El-Wagaa, Jenna A., Doyle, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Impedance Tests Administration, Intranasal Administration, Topical Adult Cross-Over Studies Double-Blind Method Ear, Middle - drug effects Ear, Middle - metabolism Female Healthy Volunteers Histamine - pharmacology Histamine Agonists - pharmacology Humans Inflammation Male Middle Aged Nasal Mucosa - drug effects Nasal Mucosa - metabolism Nitrous Oxide - metabolism Regional Blood Flow Young Adult
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