The Role of GluN2A in Cerebral Ischemia: Promoting Neuron Death and Survival in the Early Stage and Thereafter

Over-activation of NMDA receptors is a crucial step required for brain damage following a stroke. Although clinical trials for NMDA receptor blockers have failed, the role of GluN2A subunit in cerebral ischemia has been extensively evaluated in recent years. However, the effect of GluN2A on neuron d...

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Veröffentlicht in:	Molecular neurobiology 2018-02, Vol.55 (2), p.1208-1216
Hauptverfasser:	Sun, Yongjun, Cheng, Xiaokun, Hu, Jie, Gao, Zibin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brain injury Brain Ischemia - metabolism Brain Ischemia - pathology Calcium signalling Cell Biology Cell death Cell Death - physiology Cell Survival - physiology Cerebrum Clinical trials Glutamic acid receptors (ionotropic) Humans Ischemia N-Methyl-D-aspartic acid receptors Neurobiology Neurology Neurons - metabolism Neurons - pathology Neurosciences Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - physiology
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