PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy

Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1′s and PLK1′s functions are mostly studied separatel...

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Veröffentlicht in:	Autophagy 2017-03, Vol.13 (3), p.486-505
Hauptverfasser:	Ruf, Stefanie, Heberle, Alexander Martin, Langelaar-Makkinje, Miriam, Gelino, Sara, Wilkinson, Deepti, Gerbeth, Carolin, Schwarz, Jennifer Jasmin, Holzwarth, Birgit, Warscheid, Bettina, Meisinger, Chris, van Vugt, Marcel A. T. M., Baumeister, Ralf, Hansen, Malene, Thedieck, Kathrin
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid Amino Acids - deficiency Amino Acids - metabolism Animals Autophagy Basic Research Papers BI2536 Biomarkers - metabolism Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism HeLa Cells Humans insulin Interphase lysosome Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 - metabolism Mitosis MTOR MTORC1 Phosphorylation PLK1 Polo-Like Kinase 1 Protein Binding Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Regulatory-Associated Protein of mTOR - metabolism RPTOR starvation TOR Serine-Threonine Kinases - metabolism
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