Development of Timolol-Loaded Galactosylated Chitosan Nanoparticles and Evaluation of Their Potential for Ocular Drug Delivery

This study was conducted to develop timolol maleate (TM)-loaded galactosylated chitosan (GC) nanoparticles (NPs) (TM-GC-NPs) followed by optimization via a four-level and three-factor Box–Behnken statistical experimental design. The optimized nanoparticles showed a particle size of 213.3 ± 6.83 nm w...

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Veröffentlicht in:	AAPS PharmSciTech 2017-05, Vol.18 (4), p.997-1008
Hauptverfasser:	Zhao, Ruobing, Li, Jing, Wang, Jingyi, Yin, Zhenya, Zhu, Yongtao, Liu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology Biochemistry Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical and Life Sciences Biomedicine Biotechnology Calorimetry, Differential Scanning - methods Chitosan - chemistry Chitosan - pharmacology Cornea Drug Delivery Systems Intraocular Pressure - drug effects Nanoparticles Particle Size Pharmacology/Toxicology Pharmacy Rabbits Research Article Theme: Recent Trends in the Development of Chitosan-Based Drug Delivery Systems Timolol - chemistry Timolol - pharmacology
Online-Zugang:	Volltext
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