Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells

[Display omitted] •The Ononin inhibited the productions of NO, PGE2, TNF-α, IL-1β and IL-6.•The Ononin inhibited mRNA expression of COX-2 and iNOS.•The Ononin inhibited the phosphorylation of IκBα and MAPKs. Increasing evidence has shown that ononin, a major isoflavone, has anti-inflammatory effects...

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Veröffentlicht in:	Molecular immunology 2017-03, Vol.83, p.46-51
Hauptverfasser:	Dong, Lin, Yin, Lei, Zhang, Yuanbin, Fu, Xueyan, Lu, Jincai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Blotting, Western Cell Survival - drug effects Enzyme-Linked Immunosorbent Assay Glucosides - pharmacology Inflammation Inflammation - immunology Inflammatory cytokines Isoflavones - pharmacology Lipopolysaccharides - immunology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Mapk Mice NF-kappa B - drug effects NF-kappa B - immunology NF-kappa B - metabolism NF-κB Ononin RAW 264.7 Cells Signal Transduction - drug effects Signal Transduction - immunology
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