Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation

TP508 is a synthetically derived tissue repair peptide that has previously demonstrated safety and potential efficacy in phase I/II clinical trials for the treatment of diabetic foot ulcers. Recent studies show that a single injection of TP508 administered 24 h after irradiation significantly increa...

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Veröffentlicht in:	The AAPS journal 2017-05, Vol.19 (3), p.743-753
Hauptverfasser:	McVicar, Scott D., Rayavara, Kempaiah, Carney, Darrell H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Cells, Cultured DNA Repair - drug effects Drug Delivery Systems Half-Life Histones Humans Male Mice Neovascularization, Physiologic - drug effects Peptide Fragments - administration & dosage Peptide Fragments - chemistry Peptide Fragments - pharmacology Pharmacology/Toxicology Pharmacy Polyethylene Glycols - chemistry Radiation-Protective Agents - administration & dosage Radiation-Protective Agents - chemistry Radiation-Protective Agents - pharmacology Research Article Thrombin - administration & dosage Thrombin - chemistry Thrombin - pharmacology Wound Healing - drug effects
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