In Hepatocellular Carcinoma miR-221 Modulates Sorafenib Resistance through Inhibition of Caspase-3-Mediated Apoptosis

The aberrant expression of miR-221 is a hallmark of human cancers, including hepatocellular carcinoma (HCC), and its involvement in drug resistance, together with a proved efficacy of anti-miR-221 molecules, strengthen its role as an attractive target candidate in the oncologic field. The discovery...

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Veröffentlicht in:	Clinical cancer research 2017-07, Vol.23 (14), p.3953-3965
Hauptverfasser:	Fornari, Francesca, Pollutri, Daniela, Patrizi, Clarissa, La Bella, Tiziana, Marinelli, Sara, Casadei Gardini, Andrea, Marisi, Giorgia, Baron Toaldo, Marco, Baglioni, Michele, Salvatore, Veronica, Callegari, Elisa, Baldassarre, Maurizio, Galassi, Marzia, Giovannini, Catia, Cescon, Matteo, Ravaioli, Matteo, Negrini, Massimo, Bolondi, Luigi, Gramantieri, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Aged Aged, 80 and over Animal models Animals Apoptosis Apoptosis - genetics Biomarkers Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Caspase Caspase 3 - genetics Caspase-3 Cell Proliferation - drug effects Data processing Drug resistance Drug Resistance, Neoplasm - genetics Experimental design Female Functional analysis Gene Expression Regulation, Neoplastic - drug effects Hep G2 Cells Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mice MicroRNAs - genetics Middle Aged Modulation Niacinamide - administration & dosage Niacinamide - adverse effects Niacinamide - analogs & derivatives Overexpression Patients Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Rodents Serum levels Target recognition Xenograft Model Antitumor Assays Xenografts
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