Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt‐mTORC1 pathway depending on activation of p70S6K and Cdc2

We previously demonstrated that coxsackievirus B3 (CVB3) infection upregulated heat shock protein 70 (Hsp70) and promoted CVB3 multiplication. Here, we report the underlying mechanism by which Hsp70 enhances viral RNA translation. By using an Hsp70‐overexpressing cell line infected with CVB3, we fou...

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Veröffentlicht in:	Cellular microbiology 2017-07, Vol.19 (7), p.e12725-n/a
Hauptverfasser:	Wang, Fengping, Qiu, Ye, Zhang, Huifang M., Hanson, Paul, Ye, Xin, Zhao, Guangze, Xie, Ronald, Tong, Lei, Yang, Decheng
Format:	Artikel
Sprache:	eng
Schlagworte:	4EBP1 Activation Adaptor Proteins, Signal Transducing - biosynthesis AKT protein Akt‐mTORC1 Cdc2 Cdc2 protein CDC2 Protein Kinase - metabolism Cell division Cell Line, Tumor Cellular communication Chaperones Coxsackievirus Infections - virology Coxsackieviruses CVB3 Cycle protein Deactivation Elongation Enterovirus B, Human - growth & development Enterovirus B, Human - metabolism Eukaryotic Initiation Factor-2 - metabolism Heat shock proteins HeLa Cells Homology Hsp70 HSP70 Heat-Shock Proteins - biosynthesis HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Inactivation Initiation factor eIF-4E Internal ribosome entry site Kinases Mammals Mechanistic Target of Rapamycin Complex 1 - metabolism Multiplication p70S6K Peptide Chain Elongation, Translational - physiology Peptide Chain Initiation, Translational - physiology Phosphoproteins - biosynthesis Phosphorylation Protein Biosynthesis - physiology Rapamycin Ribonucleic acid Ribosomal Protein S6 Kinases, 70-kDa - metabolism RNA RNA Interference RNA, Small Interfering - genetics Signal transduction siRNA TOR protein Transduction Translation elongation Translation initiation Viral infections Viral Structural Proteins - biosynthesis Virus Replication - physiology VP1 protein
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