Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer

Purpose Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. Methods We assessed 91...

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Veröffentlicht in:	Breast cancer research and treatment 2017-02, Vol.162 (1), p.39-48
Hauptverfasser:	Ma, Ding, Jiang, Yi-Zhou, Liu, Xi-Yu, Liu, Yi-Rong, Shao, Zhi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans Aged Aged, 80 and over Algorithms Alleles Biomarkers, Tumor Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer genetics Cancer research Cancer therapies Computational Biology - methods Databases, Genetic Development and progression DNA Copy Number Variations Female Genes Genetic aspects Genetic Association Studies Genetic Heterogeneity Genetic Predisposition to Disease Genetics Genomes Genomics Health aspects Humans Medical research Medicine Medicine & Public Health Middle Aged Mutation Neoplasm Metastasis Neoplasm Staging Oncology Preclinical Study Prognosis Tumor proteins Whole Exome Sequencing Women's health Young Adult
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