ERCC1 and ERCC2 as predictive biomarkers to oxaliplatin-based chemotherapy in colorectal cancer patients from Egypt

The impact of Excision repair cross-complementation group 1 (ERCC1) and group 2 (ERCC2) expression levels on the efficacy of oxaliplatin-based chemotherapy is still controversial. The present study was conducted to determine the predictive value of these molecular biomarkers in stage III and IV colo...

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Veröffentlicht in:	Experimental and molecular pathology 2017-02, Vol.102 (1), p.78-85
Hauptverfasser:	Kassem, Amira B., Salem, Salem Eid, Abdelrahim, Mohamed E., Said, Amira S.A., Salahuddin, Ahmad, Hussein, Marwa Mahmoud, Bahnassy, Abeer A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology CRC DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Egypt Endonucleases - biosynthesis Endonucleases - genetics ERCC1 ERCC2 Female Follow-Up Studies Gene Expression Regulation, Neoplastic - drug effects Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Neoplasm Staging Organoplatinum Compounds - administration & dosage Outcome Assessment (Health Care) - methods Outcome Assessment (Health Care) - statistics & numerical data Oxaliplatin Proportional Hazards Models Reverse Transcriptase Polymerase Chain Reaction Survival Xeroderma Pigmentosum Group D Protein - biosynthesis Xeroderma Pigmentosum Group D Protein - genetics Young Adult
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