Recombinant thrombomodulin suppresses tumor growth of pancreatic cancer by blocking thrombin-induced PAR1 and NF-κB activation

Background Thrombomodulin, an anticoagulant that inhibits thrombin-induced growth factor promotion, also has an anti-inflammatory effect. Furthermore, thrombomodulin inhibits nuclear factor-kappa B activation, which plays a crucial role in cancer progression. We assessed the antitumor activity of re...

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Veröffentlicht in:	Surgery 2017-06, Vol.161 (6), p.1675-1682
Hauptverfasser:	Shirai, Yoshihiro, MD, PhD, Uwagawa, Tadashi, MD, PhD, Shiba, Hiroaki, MD, PhD, Shimada, Yohta, PhD, Horiuchi, Takashi, MD, Saito, Nobuhiro, MD, Furukawa, Kenei, MD, PhD, Ohashi, Toya, MD, PhD, Yanaga, Katsuhiko, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopsy, Needle Disease Models, Animal Gene Expression Regulation, Neoplastic - drug effects Humans I-kappa B Kinase - drug effects I-kappa B Kinase - genetics Immunohistochemistry Injections, Intraperitoneal Male Mice Mice, Inbred BALB C Neoplasm Transplantation NF-kappa B - antagonists & inhibitors Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Random Allocation Reference Values Signal Transduction - drug effects Surgery Thrombomodulin - administration & dosage
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