In vitro antitumor and antiangiogenic effects of Bothropoidin, a metalloproteinase from Bothrops pauloensis snake venom

Breast cancer is a highly malignant carcinoma and remains the second leading cause of mortality among women. The antitumor effects of metalloproteinases and disintegrins from snake venom on various types of cancer cells have been investigated. In this study, we evaluated the antitumor and antiangiog...

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Veröffentlicht in:	International journal of biological macromolecules 2017-04, Vol.97, p.770-777
Hauptverfasser:	Guimarães, Denise de Oliveira, Lopes, Daiana Silva, Azevedo, Fernanda Van Petten Vasconcelos, Gimenes, Sarah Natalie Cirilo, Silva, Makswell Almeida, Achê, David Collares, Gomes, Mário Sérgio Rocha, Vecchi, Lara, Goulart, Luiz Ricardo, Yoneyama, Kelly Aparecida Geraldo, Rodrigues, Renata Santos, Rodrigues, Veridiana de Melo
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - isolation & purification Angiogenesis Inhibitors - pharmacology Animals Antiangiogenic Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antitumor Bothrops Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Crotalid Venoms - enzymology Humans MDA-MB-231 cells Metalloproteases - isolation & purification Metalloproteases - pharmacology Snake venom metalloproteinase
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