Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice

•White adipose tissue (WAT), plasma leptin and leptin mRNA in WAT are lastingly reduced after chronic early-life stress (ES).•Brown adipose tissue mass and browning of WAT is increased after ES exposure.•Leptin receptor expression is upregulated in the choroid plexus and unaffected in the hippocampu...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-03, Vol.77, p.186-195
Hauptverfasser:	Yam, K.Y., Naninck, E.F.G., Abbink, M.R., la Fleur, S.E., Schipper, L., van den Beukel, J.C., Grefhorst, A., Oosting, A., van der Beek, E.M., Lucassen, P.J., Korosi, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocyte metabolism Adipose Tissue - metabolism Animals Choroid plexus Cognitive impairments Diet, Western Disease Models, Animal Early-life stress Feeding Behavior - physiology Leptin - blood Leptin - genetics Leptin - metabolism Mice Obesity - blood Obesity - genetics Obesity - metabolism Sex differences Stress, Psychological - metabolism Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism Western-style diet
Online-Zugang:	Volltext
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