A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa
Background The aim of the present study was to investigate whether the baseline impedance (BI) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI) children undergoing multichannel intraluminal impedance pH measurements (pH/MII). Methods The...
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| Veröffentlicht in: | Neurogastroenterology and motility 2017-06, Vol.29 (6), p.n/a |
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| creator | Fukahori, S. Yagi, M. Ishii, S. Asagiri, K. Saikusa, N. Hashizume, N. Yoshida, M. Masui, D. Komatsuzaki, N. Higashidate, N. Nakahara, H. Tanaka, Y. |
| description | Background
The aim of the present study was to investigate whether the baseline impedance (BI) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI) children undergoing multichannel intraluminal impedance pH measurements (pH/MII).
Methods
The retrospective study included 55 NI patients ≤15 years. The patients were divided into acid gastroesophageal reflux disease (GERD), non‐acid GERD and GERD (−) groups. Furthermore, the patients in the acid GERD group were subdivided into erosive reflux disease (ERD) and non‐erosive reflux disease (NERD) groups. pH/MII parameters and BI values (Z1‐6) were compared among three groups or between two groups, respectively. A Spearman's correlation analysis was used for the correlation analysis of pH/MII parameters and BI values. A receiver operator characteristic curve analysis was used to evaluate the optimum cut‐off values of BI to discriminate ERD patients.
Key Results
The BI values of the proximal and the distal channels in ERD group were significantly lower than those in NERD group. The BI values of the distal channels demonstrated significant negative correlations with acid exposure related pH/MII parameters. The optimal cut off value of BI in the most distal channel was determined to be 1500 Ω.
Conclusions & Inferences
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. Baseline impedance is a potent parameter, reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. BI is a potent parameter reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations. |
| doi_str_mv | 10.1111/nmo.13012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1861524598</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1861524598</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4192-4a2f5390e3594b1ef8084f6aee2cdf907e1f1c78bfee253c51a47b1ac18e0b2e3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi0EoqVw4AWQJS5wSOtxYm_CbVXxTyr0Audo4ox3XTl2sBOhfQZeGm-3cEBiLjMa_fRpvvkYewniEkpdhSleQi1APmLnUGtVya6Vj4-zEhV0Up2xZznfCSG0bPRTdiZb0WqpxTn7teUDZvIuEHfTTCMGQxwD-kN2mbvAA60p-rhzBr0_HCF0iUZu9s6PicI7vuVzXCgsfMaEEy2UuI2JU17chIsLO77siZsYRre4GHi09wvKcd7jjtDzaTUx43P2xKLP9OKhX7DvH95_u_5U3dx-_Hy9valMU8xUDUqr6k5QrbpmALLFTGM1Ekkz2k5sCCyYTTvYslG1UYDNZgA00JIYJNUX7M1Jd07xx1rO7CeXDXmPgeKae2g1KNmori3o63_Qu7im8p0j1WkJGwW6UG9PlEkx50S2n1Oxng49iP6YUF8S6u8TKuyrB8V1mGj8S_6JpABXJ-Cn83T4v1L_9cvtSfI3_S6cvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1896217516</pqid></control><display><type>article</type><title>A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Fukahori, S. ; Yagi, M. ; Ishii, S. ; Asagiri, K. ; Saikusa, N. ; Hashizume, N. ; Yoshida, M. ; Masui, D. ; Komatsuzaki, N. ; Higashidate, N. ; Nakahara, H. ; Tanaka, Y.</creator><creatorcontrib>Fukahori, S. ; Yagi, M. ; Ishii, S. ; Asagiri, K. ; Saikusa, N. ; Hashizume, N. ; Yoshida, M. ; Masui, D. ; Komatsuzaki, N. ; Higashidate, N. ; Nakahara, H. ; Tanaka, Y.</creatorcontrib><description>Background
The aim of the present study was to investigate whether the baseline impedance (BI) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI) children undergoing multichannel intraluminal impedance pH measurements (pH/MII).
Methods
The retrospective study included 55 NI patients ≤15 years. The patients were divided into acid gastroesophageal reflux disease (GERD), non‐acid GERD and GERD (−) groups. Furthermore, the patients in the acid GERD group were subdivided into erosive reflux disease (ERD) and non‐erosive reflux disease (NERD) groups. pH/MII parameters and BI values (Z1‐6) were compared among three groups or between two groups, respectively. A Spearman's correlation analysis was used for the correlation analysis of pH/MII parameters and BI values. A receiver operator characteristic curve analysis was used to evaluate the optimum cut‐off values of BI to discriminate ERD patients.
Key Results
The BI values of the proximal and the distal channels in ERD group were significantly lower than those in NERD group. The BI values of the distal channels demonstrated significant negative correlations with acid exposure related pH/MII parameters. The optimal cut off value of BI in the most distal channel was determined to be 1500 Ω.
Conclusions & Inferences
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. Baseline impedance is a potent parameter, reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. BI is a potent parameter reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13012</identifier><identifier>PMID: 28086260</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acids ; baseline impedance ; Child ; Child, Preschool ; Children ; Correlation analysis ; Electric Impedance ; erosive reflux disease ; Esophageal Mucosa - physiopathology ; Esophageal pH Monitoring - methods ; Esophagitis ; Esophagus ; Female ; Gastroesophageal reflux ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - diagnosis ; Humans ; Male ; Mucosa ; Mucous membrane ; multichannel intraluminal impedance measurements ; Nervous System Diseases - complications ; neurologically impaired ; pediatric ; pH effects ; Retrospective Studies</subject><ispartof>Neurogastroenterology and motility, 2017-06, Vol.29 (6), p.n/a</ispartof><rights>2017 John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4192-4a2f5390e3594b1ef8084f6aee2cdf907e1f1c78bfee253c51a47b1ac18e0b2e3</citedby><cites>FETCH-LOGICAL-c4192-4a2f5390e3594b1ef8084f6aee2cdf907e1f1c78bfee253c51a47b1ac18e0b2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13012$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13012$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28086260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukahori, S.</creatorcontrib><creatorcontrib>Yagi, M.</creatorcontrib><creatorcontrib>Ishii, S.</creatorcontrib><creatorcontrib>Asagiri, K.</creatorcontrib><creatorcontrib>Saikusa, N.</creatorcontrib><creatorcontrib>Hashizume, N.</creatorcontrib><creatorcontrib>Yoshida, M.</creatorcontrib><creatorcontrib>Masui, D.</creatorcontrib><creatorcontrib>Komatsuzaki, N.</creatorcontrib><creatorcontrib>Higashidate, N.</creatorcontrib><creatorcontrib>Nakahara, H.</creatorcontrib><creatorcontrib>Tanaka, Y.</creatorcontrib><title>A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
The aim of the present study was to investigate whether the baseline impedance (BI) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI) children undergoing multichannel intraluminal impedance pH measurements (pH/MII).
Methods
The retrospective study included 55 NI patients ≤15 years. The patients were divided into acid gastroesophageal reflux disease (GERD), non‐acid GERD and GERD (−) groups. Furthermore, the patients in the acid GERD group were subdivided into erosive reflux disease (ERD) and non‐erosive reflux disease (NERD) groups. pH/MII parameters and BI values (Z1‐6) were compared among three groups or between two groups, respectively. A Spearman's correlation analysis was used for the correlation analysis of pH/MII parameters and BI values. A receiver operator characteristic curve analysis was used to evaluate the optimum cut‐off values of BI to discriminate ERD patients.
Key Results
The BI values of the proximal and the distal channels in ERD group were significantly lower than those in NERD group. The BI values of the distal channels demonstrated significant negative correlations with acid exposure related pH/MII parameters. The optimal cut off value of BI in the most distal channel was determined to be 1500 Ω.
Conclusions & Inferences
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. Baseline impedance is a potent parameter, reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. BI is a potent parameter reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.</description><subject>Acids</subject><subject>baseline impedance</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Correlation analysis</subject><subject>Electric Impedance</subject><subject>erosive reflux disease</subject><subject>Esophageal Mucosa - physiopathology</subject><subject>Esophageal pH Monitoring - methods</subject><subject>Esophagitis</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - diagnosis</subject><subject>Humans</subject><subject>Male</subject><subject>Mucosa</subject><subject>Mucous membrane</subject><subject>multichannel intraluminal impedance measurements</subject><subject>Nervous System Diseases - complications</subject><subject>neurologically impaired</subject><subject>pediatric</subject><subject>pH effects</subject><subject>Retrospective Studies</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9u1DAQxi0EoqVw4AWQJS5wSOtxYm_CbVXxTyr0Audo4ox3XTl2sBOhfQZeGm-3cEBiLjMa_fRpvvkYewniEkpdhSleQi1APmLnUGtVya6Vj4-zEhV0Up2xZznfCSG0bPRTdiZb0WqpxTn7teUDZvIuEHfTTCMGQxwD-kN2mbvAA60p-rhzBr0_HCF0iUZu9s6PicI7vuVzXCgsfMaEEy2UuI2JU17chIsLO77siZsYRre4GHi09wvKcd7jjtDzaTUx43P2xKLP9OKhX7DvH95_u_5U3dx-_Hy9valMU8xUDUqr6k5QrbpmALLFTGM1Ekkz2k5sCCyYTTvYslG1UYDNZgA00JIYJNUX7M1Jd07xx1rO7CeXDXmPgeKae2g1KNmori3o63_Qu7im8p0j1WkJGwW6UG9PlEkx50S2n1Oxng49iP6YUF8S6u8TKuyrB8V1mGj8S_6JpABXJ-Cn83T4v1L_9cvtSfI3_S6cvQ</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Fukahori, S.</creator><creator>Yagi, M.</creator><creator>Ishii, S.</creator><creator>Asagiri, K.</creator><creator>Saikusa, N.</creator><creator>Hashizume, N.</creator><creator>Yoshida, M.</creator><creator>Masui, D.</creator><creator>Komatsuzaki, N.</creator><creator>Higashidate, N.</creator><creator>Nakahara, H.</creator><creator>Tanaka, Y.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa</title><author>Fukahori, S. ; Yagi, M. ; Ishii, S. ; Asagiri, K. ; Saikusa, N. ; Hashizume, N. ; Yoshida, M. ; Masui, D. ; Komatsuzaki, N. ; Higashidate, N. ; Nakahara, H. ; Tanaka, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4192-4a2f5390e3594b1ef8084f6aee2cdf907e1f1c78bfee253c51a47b1ac18e0b2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acids</topic><topic>baseline impedance</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Correlation analysis</topic><topic>Electric Impedance</topic><topic>erosive reflux disease</topic><topic>Esophageal Mucosa - physiopathology</topic><topic>Esophageal pH Monitoring - methods</topic><topic>Esophagitis</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - diagnosis</topic><topic>Humans</topic><topic>Male</topic><topic>Mucosa</topic><topic>Mucous membrane</topic><topic>multichannel intraluminal impedance measurements</topic><topic>Nervous System Diseases - complications</topic><topic>neurologically impaired</topic><topic>pediatric</topic><topic>pH effects</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukahori, S.</creatorcontrib><creatorcontrib>Yagi, M.</creatorcontrib><creatorcontrib>Ishii, S.</creatorcontrib><creatorcontrib>Asagiri, K.</creatorcontrib><creatorcontrib>Saikusa, N.</creatorcontrib><creatorcontrib>Hashizume, N.</creatorcontrib><creatorcontrib>Yoshida, M.</creatorcontrib><creatorcontrib>Masui, D.</creatorcontrib><creatorcontrib>Komatsuzaki, N.</creatorcontrib><creatorcontrib>Higashidate, N.</creatorcontrib><creatorcontrib>Nakahara, H.</creatorcontrib><creatorcontrib>Tanaka, Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukahori, S.</au><au>Yagi, M.</au><au>Ishii, S.</au><au>Asagiri, K.</au><au>Saikusa, N.</au><au>Hashizume, N.</au><au>Yoshida, M.</au><au>Masui, D.</au><au>Komatsuzaki, N.</au><au>Higashidate, N.</au><au>Nakahara, H.</au><au>Tanaka, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2017-06</date><risdate>2017</risdate><volume>29</volume><issue>6</issue><epage>n/a</epage><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
The aim of the present study was to investigate whether the baseline impedance (BI) value is a useful parameter to evaluate the condition of the esophageal mucosa in neurologically impaired (NI) children undergoing multichannel intraluminal impedance pH measurements (pH/MII).
Methods
The retrospective study included 55 NI patients ≤15 years. The patients were divided into acid gastroesophageal reflux disease (GERD), non‐acid GERD and GERD (−) groups. Furthermore, the patients in the acid GERD group were subdivided into erosive reflux disease (ERD) and non‐erosive reflux disease (NERD) groups. pH/MII parameters and BI values (Z1‐6) were compared among three groups or between two groups, respectively. A Spearman's correlation analysis was used for the correlation analysis of pH/MII parameters and BI values. A receiver operator characteristic curve analysis was used to evaluate the optimum cut‐off values of BI to discriminate ERD patients.
Key Results
The BI values of the proximal and the distal channels in ERD group were significantly lower than those in NERD group. The BI values of the distal channels demonstrated significant negative correlations with acid exposure related pH/MII parameters. The optimal cut off value of BI in the most distal channel was determined to be 1500 Ω.
Conclusions & Inferences
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. Baseline impedance is a potent parameter, reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.
The present study suggested that NI children with reflux esophagitis were likely to suffer mucosal damage up to the proximal esophagus and cut‐off BI values may help estimate the presence of reflux esophagitis. BI is a potent parameter reflecting the esophageal mucosal damage in NI children who have difficulty in undergoing endoscopic examinations.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28086260</pmid><doi>10.1111/nmo.13012</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | Acids baseline impedance Child Child, Preschool Children Correlation analysis Electric Impedance erosive reflux disease Esophageal Mucosa - physiopathology Esophageal pH Monitoring - methods Esophagitis Esophagus Female Gastroesophageal reflux Gastroesophageal Reflux - complications Gastroesophageal Reflux - diagnosis Humans Male Mucosa Mucous membrane multichannel intraluminal impedance measurements Nervous System Diseases - complications neurologically impaired pediatric pH effects Retrospective Studies |
| title | A baseline impedance analysis in neurologically impaired children: A potent parameter for estimating the condition of the esophageal mucosa |
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