Cisplatin Induces Apoptosis Through the Endoplasmic Reticulum-mediated, Calpain 1 Pathway in Triple-negative Breast Cancer Cells

Chemoresistance of triple-negative breast cancer (TNBC) is a major obstacle for successful treatment and is mainly represented as a defect in apoptosis. Using advanced techniques in molecular biology, we show that calpain 1 plays an essential role in modulating TNBC cell sensitivity to cisplatin-ind...

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Veröffentlicht in:	Clinical breast cancer 2017-06, Vol.17 (3), p.e103-e112
Hauptverfasser:	Al-Bahlani, Shadia M., Al-Bulushi, Khadija H., Al-Alawi, Zaina M., Al-Abri, Nadia Y., Al-Hadidi, Zuweina R., Al-Rawahi, Shaikha S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Breast cancer Calcium - metabolism Calcium-dependent proteases Calpain - metabolism Cell Proliferation - drug effects Cisplatin - pharmacology Electron microscope Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Female Gene Expression Regulation, Neoplastic - drug effects Humans Programmed cell death Signal Transduction - drug effects Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumor Cells, Cultured Western blot
Online-Zugang:	Volltext
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