Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis
Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the...
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Veröffentlicht in: | Journal of pediatric hematology/oncology 2017-08, Vol.39 (6), p.e325-e327 |
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container_title | Journal of pediatric hematology/oncology |
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creator | Kumral, Abigail V W Petersen, Jr, William C Heitz, Christopher Waggoner-Fountain, Linda A Belyea, Brian C |
description | Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the underlying trigger. In this report, we describe the clinical presentation, diagnostic findings, management, and outcome of a child with Lemierre's syndrome-associated sHLH. This is the first reported association of these 2 rare conditions and expands the number of known triggers for sHLH. |
doi_str_mv | 10.1097/MPH.0000000000000755 |
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Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the underlying trigger. In this report, we describe the clinical presentation, diagnostic findings, management, and outcome of a child with Lemierre's syndrome-associated sHLH. 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Successful treatment of this potentially fatal condition requires early recognition and prompt therapy directed at the underlying trigger. In this report, we describe the clinical presentation, diagnostic findings, management, and outcome of a child with Lemierre's syndrome-associated sHLH. This is the first reported association of these 2 rare conditions and expands the number of known triggers for sHLH.</description><subject>Adolescent</subject><subject>Diagnosis, Differential</subject><subject>Disease Management</subject><subject>Female</subject><subject>Humans</subject><subject>Lemierre Syndrome - complications</subject><subject>Lymphohistiocytosis, Hemophagocytic - diagnosis</subject><subject>Lymphohistiocytosis, Hemophagocytic - etiology</subject><subject>Lymphohistiocytosis, Hemophagocytic - therapy</subject><subject>Treatment Outcome</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9Lw0AQxRdRbK1-A5G96SV1N_s3RynVChGV1nPYbibtStONu-kh396UVhHnMsPjvRnmh9A1JWNKMnX_8jYbk7-lhDhBQyqYTJhU-rSfiVIJp5QP0EWMn4RQxXh6jgapJlooQYfoPYfaQQhwG_G825bB14BNxAYvglutIODKBzwH67elCR2eQe2btVl527XO4ryrm7Vfu9i6veKji5forDKbCFfHPkIfj9PFZJbkr0_Pk4c8sYyoNpGgJdM8MxY0NURSWwG3mahMqkVpQXLba6nmmiyJ5IaUBHjKK5oZCVxJNkJ3h71N8F87iG1Ru2hhszFb8LtYUC2poJxI1lv5wWqDjzFAVTTB1f07BSXFHmbRwyz-w-xjN8cLu2UN5W_ohx77Bi6db7o</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Kumral, Abigail V W</creator><creator>Petersen, Jr, William C</creator><creator>Heitz, Christopher</creator><creator>Waggoner-Fountain, Linda A</creator><creator>Belyea, Brian C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170801</creationdate><title>Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis</title><author>Kumral, Abigail V W ; Petersen, Jr, William C ; Heitz, Christopher ; Waggoner-Fountain, Linda A ; Belyea, Brian C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-6e863849ace81a061cfe4c95fa285dce64c61c28480b064a0d0e424f19a6e4763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Diagnosis, Differential</topic><topic>Disease Management</topic><topic>Female</topic><topic>Humans</topic><topic>Lemierre Syndrome - complications</topic><topic>Lymphohistiocytosis, Hemophagocytic - diagnosis</topic><topic>Lymphohistiocytosis, Hemophagocytic - etiology</topic><topic>Lymphohistiocytosis, Hemophagocytic - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumral, Abigail V W</creatorcontrib><creatorcontrib>Petersen, Jr, William C</creatorcontrib><creatorcontrib>Heitz, Christopher</creatorcontrib><creatorcontrib>Waggoner-Fountain, Linda A</creatorcontrib><creatorcontrib>Belyea, Brian C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumral, Abigail V W</au><au>Petersen, Jr, William C</au><au>Heitz, Christopher</au><au>Waggoner-Fountain, Linda A</au><au>Belyea, Brian C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>39</volume><issue>6</issue><spage>e325</spage><epage>e327</epage><pages>e325-e327</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><abstract>Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare hyperinflammatory disorder caused by an aberrant immune response to a number of infectious or inflammatory conditions. 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subjects | Adolescent Diagnosis, Differential Disease Management Female Humans Lemierre Syndrome - complications Lymphohistiocytosis, Hemophagocytic - diagnosis Lymphohistiocytosis, Hemophagocytic - etiology Lymphohistiocytosis, Hemophagocytic - therapy Treatment Outcome |
title | Lemierre's Syndrome as a Trigger for Secondary Hemophagocytic Lymphohistiocytosis |
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