Micromolar Levels of Sodium Fluoride Promote Osteoblast Differentiation Through Runx2 Signaling

Bone remodeling is a vital physiological process of healthy bone tissue in humans. Imbalances in this vital process lead to pathological conditions, including periodontal diseases. In this study, we characterized the effects of micromolar levels of NaF on the proliferation and osteogenic differentia...

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Veröffentlicht in:	Biological trace element research 2017-08, Vol.178 (2), p.283-291
Hauptverfasser:	Lee, Masahiro, Arikawa, Kazumune, Nagahama, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Alveolar bone Animal models Animals Antigens, Differentiation - biosynthesis Biochemistry Biocompatibility Biomedical and Life Sciences Biomedical materials Biotechnology Bone diseases Bone loss Bone remodeling Bones Cbfa-1 protein Cell Differentiation - drug effects Cell Line Cell proliferation Cells Cellular biology Core Binding Factor Alpha 1 Subunit - metabolism Differentiation Disorders DNA Fluorides Life Sciences Mice Mineralization Nucleotide sequence Nutrition Oncology Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin Osteopontin PCR Periodontal diseases Periodontitis Phosphatase Polymerase chain reaction Proliferation Real time Signal transduction Signal Transduction - drug effects siRNA Sodium Sodium fluoride Sodium Fluoride - pharmacology Tissue Transcription
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