Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites

The identification of common virus integration sites (cVIS) in retrovirally induced tumors in mice provides a powerful strategy to isolate novel transforming genes. Applying virus LTR-specific inverse-PCR and RT-PCR combined with automated sequencing on CasBr-M Murine Leukemia Virus (MuLV) induced m...

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Veröffentlicht in:	Oncogene 2002-10, Vol.21 (47), p.7247-7255
Hauptverfasser:	Joosten, Marieke, Vankan-Berkhoudt, Yolanda, Tas, Marjolein, Lunghi, Monja, Jenniskens, Yvonne, Parganas, Evan, Valk, Peter J M, Löwenberg, Bob, van den Akker, Eric, Delwel, Ruud
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Southern c-Myb protein Cancer Cloning Cloning, Molecular Gene therapy Genetic aspects Health aspects Identification and classification Insertion Integration Leukemia Leukemia Virus, Murine Leukemia, Myeloid - genetics Mice Mouse leukemia viruses Mutagenesis, Insertional Nucleoside-diphosphate kinase Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Risk factors Terminal Repeat Sequences Tumor Cells, Cultured Tumors Virus Integration Viruses
Online-Zugang:	Volltext
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