Genetic analysis of collagen-induced arthritis in rats: a polygenic model for rheumatoid arthritis predicts a common framework of cross-species inflammatory/autoimmune disease loci

Collagen‐induced arthritis (CIA) is a useful model for dissecting the genetic patterns underlying susceptibility to rheumatoid arthritis (RA) and related chronic/inflammatory autoimmune diseases. CIA exhibits three phenotypes characteristic of autoimmune disease pathogenesis: abnormal levels of immu...

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Veröffentlicht in:	Immunological reviews 2001-12, Vol.184 (1), p.172-183
Hauptverfasser:	Griffiths, Marie M., Remmers, Elaine F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - chemically induced Arthritis, Rheumatoid - genetics Autoimmune Diseases - genetics Collagen - adverse effects Disease Models, Animal Genetic Predisposition to Disease Humans Major Histocompatibility Complex Quantitative Trait, Heritable Rats Sex Factors
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