PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

Mechanisms linking mitogenic and growth inhibitory cytokine signaling and the cell cycle have not been fully elucidated in either cancer or in normal cells. Here we show that activation of protein kinase B (PKB)/Akt, contributes to resistance to antiproliferative signals and breast cancer progressio...

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Veröffentlicht in:Nature medicine 2002-10, Vol.8 (10), p.1153-1160
Hauptverfasser: Liang, Jiyong, Zubovitz, Judit, Petrocelli, Teresa, Kotchetkov, Rouslan, Connor, Michael K., Han, Kathy, Lee, Jin-Hwa, Ciarallo, Sandra, Catzavelos, Charles, Beniston, Richard, Franssen, Edmee, Slingerland, Joyce M.
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Sprache:eng
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