Qualitative Screening for Drugs of Abuse in Hair Using GC-MS
A previously described method for the analysis of hair has been modified to include analysis for amphetamines, benzodiazepines, cocaine and its metabolites, methadone and its metabolite, and phencyclidine in addition to opiates on a sample of hair. The samples of hair were washed twice with dichloro...
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| Veröffentlicht in: | Journal of analytical toxicology 2001-04, Vol.25 (3), p.203-208 |
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| container_title | Journal of analytical toxicology |
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| creator | Paterson, Susan McLachlan-Troup, Neil Cordero, Rosa Dohnal, Martin Carman, Suzannah |
| description | A previously described method for the analysis of hair has been modified to include analysis for amphetamines, benzodiazepines, cocaine and its metabolites, methadone and its metabolite, and phencyclidine in addition to opiates on a sample of hair. The samples of hair were washed twice with dichloromethane and cut into 1-mm segments prior to extraction with methanol at 45°C for 18 h. The extracts were split into two parts; both were evaporated to dryness. One half of the extract was derivatized using MBTFA for analysis of amphetamines, and the other half was derivatized using MTBSTFA for analysis of the remaining drugs. The extracts were analyzed using electron impact gas chromatography-mass spectrometry operating in selected ion monitoring mode. In total, 18 drugs of abuse/metabolites could be detected. The method was used to screen 20 hair samples from patients attending a methadone-maintenance clinic. |
| doi_str_mv | 10.1093/jat/25.3.203 |
| format | Article |
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The samples of hair were washed twice with dichloromethane and cut into 1-mm segments prior to extraction with methanol at 45°C for 18 h. The extracts were split into two parts; both were evaporated to dryness. One half of the extract was derivatized using MBTFA for analysis of amphetamines, and the other half was derivatized using MTBSTFA for analysis of the remaining drugs. The extracts were analyzed using electron impact gas chromatography-mass spectrometry operating in selected ion monitoring mode. In total, 18 drugs of abuse/metabolites could be detected. 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The samples of hair were washed twice with dichloromethane and cut into 1-mm segments prior to extraction with methanol at 45°C for 18 h. The extracts were split into two parts; both were evaporated to dryness. One half of the extract was derivatized using MBTFA for analysis of amphetamines, and the other half was derivatized using MTBSTFA for analysis of the remaining drugs. The extracts were analyzed using electron impact gas chromatography-mass spectrometry operating in selected ion monitoring mode. In total, 18 drugs of abuse/metabolites could be detected. The method was used to screen 20 hair samples from patients attending a methadone-maintenance clinic.</description><subject>Biological and medical sciences</subject><subject>Drug addictions</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Hair - chemistry</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methadone - analysis</subject><subject>Narcotics - analysis</subject><subject>Opioid-Related Disorders - diagnosis</subject><subject>Opioid-Related Disorders - rehabilitation</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Street Drugs - analysis</subject><subject>Substance Abuse Detection</subject><subject>Toxicology</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLw0AUBeBBFK2PnWsJCLox9c47A25KfVSsiPjEzTCdTGQ0TepMIvrvTWnRpau7-TjnchDaxdDHoOjxm2mOCe_TPgG6gnpYMZ4SBnQV9QAzkTIpYANtxvgGgEUm6DrawJgSSTntoZPb1pS-MY3_dMmdDc5VvnpNijokp6F9jUldJINJG13iq2RkfEge4hxcDNPru220Vpgyup3l3UIP52f3w1E6vrm4HA7GqWWcNWkm80Jy51RuDZlQnnePGMwNF9zaTEHBJkLgXDpGnARlgJDMMZkZlStgGaNb6GCROwv1R-tio6c-WleWpnJ1GzXOBFCGoYNHC2hDHWNwhZ4FPzXhW2PQ87V0t5YmXFPdrdXxvWVuO5m6_A8v5-nA_hKYaE1ZBFNZH3-dYsDVvPVwoep29l9hupA-Nu7r15rwroWkkuvR84vm8PR4Ra7GWtAf4JiK_g</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Paterson, Susan</creator><creator>McLachlan-Troup, Neil</creator><creator>Cordero, Rosa</creator><creator>Dohnal, Martin</creator><creator>Carman, Suzannah</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20010401</creationdate><title>Qualitative Screening for Drugs of Abuse in Hair Using GC-MS</title><author>Paterson, Susan ; McLachlan-Troup, Neil ; Cordero, Rosa ; Dohnal, Martin ; Carman, Suzannah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-87df75ee9dca2b35d001a15a565cc890f4b661d7e42e709a0228e478a9d904843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Drug addictions</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Hair - chemistry</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methadone - analysis</topic><topic>Narcotics - analysis</topic><topic>Opioid-Related Disorders - diagnosis</topic><topic>Opioid-Related Disorders - rehabilitation</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Street Drugs - analysis</topic><topic>Substance Abuse Detection</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paterson, Susan</creatorcontrib><creatorcontrib>McLachlan-Troup, Neil</creatorcontrib><creatorcontrib>Cordero, Rosa</creatorcontrib><creatorcontrib>Dohnal, Martin</creatorcontrib><creatorcontrib>Carman, Suzannah</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paterson, Susan</au><au>McLachlan-Troup, Neil</au><au>Cordero, Rosa</au><au>Dohnal, Martin</au><au>Carman, Suzannah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Qualitative Screening for Drugs of Abuse in Hair Using GC-MS</atitle><jtitle>Journal of analytical toxicology</jtitle><stitle>Journal of Analytical Toxicology</stitle><addtitle>Journal of Analytical Toxicology</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>25</volume><issue>3</issue><spage>203</spage><epage>208</epage><pages>203-208</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>A previously described method for the analysis of hair has been modified to include analysis for amphetamines, benzodiazepines, cocaine and its metabolites, methadone and its metabolite, and phencyclidine in addition to opiates on a sample of hair. 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| identifier | ISSN: 0146-4760 |
| ispartof | Journal of analytical toxicology, 2001-04, Vol.25 (3), p.203-208 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library; Oxford Academic |
| subjects | Biological and medical sciences Drug addictions Gas Chromatography-Mass Spectrometry Hair - chemistry Humans Medical sciences Methadone - analysis Narcotics - analysis Opioid-Related Disorders - diagnosis Opioid-Related Disorders - rehabilitation Reference Standards Reproducibility of Results Street Drugs - analysis Substance Abuse Detection Toxicology |
| title | Qualitative Screening for Drugs of Abuse in Hair Using GC-MS |
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