Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization

To examine the local actions of IGF signaling in skeletal tissue in a physiological context, we have used Cre-mediated recombination to disrupt selectively in mouse osteoblasts the gene encoding the type 1 IGF receptor ( Igf1r ). Mice carrying this bone-specific mutation were of normal size and weig...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (46), p.44005-44012
Hauptverfasser:	Zhang, Mei, Xuan, Shouhong, Bouxsein, Mary L, von Stechow, Dietrich, Akeno, Nagako, Faugere, Marie Claude, Malluche, Hartmut, Zhao, Guisheng, Rosen, Clifford J, Efstratiadis, Argiris, Clemens, Thomas L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Matrix - metabolism Crosses, Genetic Femur - metabolism Femur - pathology Genotype Humans Insulin-Like Growth Factor I - metabolism Mice Mice, Knockout Models, Genetic Mutation Osteoblasts - metabolism Osteoclasts - metabolism Promoter Regions, Genetic Protein Binding Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Recombination, Genetic Signal Transduction Tissue Distribution Tomography, X-Ray Computed
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