14'-Hydroxymytoxin B and 16-Hydroxyroridin E, Two New Cytotoxic Trichothecenes from Myrothecium roridum

14'-Hydroxymytoxin B and 16-Hydroxyroridin E, Two New Cytotoxic Trichothecenes from Myrothecium roridum

Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2002-05, Vol.65 (5), p.742-744
Hauptverfasser: Alvi, KA, Rabenstein, J, Woodard, J, Baker, D D, Bergthold, J D, Lynch, J, Lieu, K L, Braude, IA
Format: Artikel
Sprache:eng
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Zusammenfassung:Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.
ISSN:0163-3864
DOI:10.1021/np0104491