Involvement of tumor necrosis factor (TNF-α) in arsenic trioxide induced apoptotic cell death of murine myeloid leukemia cells

Arsenic trioxide (As 2O 3) has recently been shown to be effective to inhibit the growth and to induce apoptosis in acute promyelocytic leukemia (APL) but not in acute myeloid leukemia (AML) cells. Recently, we have isolated an As 2O 3 sensitive subclone JCS-16 from the murine myeloid leukemia WEHI...

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Veröffentlicht in:	Toxicology letters 2002-09, Vol.135 (1), p.79-87
Hauptverfasser:	Mak, N.K, Wong, R.N.S, Leung, K.N, Fung, M.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Arsenic Trioxide Arsenicals Biological and medical sciences Blotting, Northern Cell Division - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Formazans - chemistry Interleukin-4 - biosynthesis Leukemia, Myeloid - metabolism Leukemia, Myeloid - pathology Medical sciences Metals and various inorganic compounds Mice Myeloid leukemia Oxides - toxicity Receptors, Interleukin-4 - biosynthesis Receptors, Tumor Necrosis Factor - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Tetrazolium Salts - chemistry TNF-R TNF-α Toxicology Tumor Cells, Cultured Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - physiology
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