Two-Dose Intrapartum/Newborn Nevirapine and Standard Antiretroviral Therapy to Reduce Perinatal HIV Transmission: A Randomized Trial

CONTEXT A 2-dose intrapartum/newborn nevirapine regimen reduced perinatal human immunodeficiency virus (HIV) transmission in Ugandan women not receiving antenatal antiretroviral therapy (ART). However, it is unknown whether the addition of the 2-dose nevirapine regimen to standard ART would further...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2002-07, Vol.288 (2), p.189-198
Hauptverfasser:	Dorenbaum, Alejandro, Cunningham, Coleen K, Gelber, Richard D, Culnane, Mary, Mofenson, Lynne, Britto, Paula, Rekacewicz, Claire, Newell, Marie-Louise, Delfraissy, Jean Francois, Cunningham-Schrader, Bethann, Mirochnick, Mark, Sullivan, John L, for the International PACTG 316 Team
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Babies Biological and medical sciences Breastfeeding & lactation CD4 Lymphocyte Count Cesarean Section Drug Administration Schedule Drug therapy Female HIV HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - prevention & control HIV Infections - transmission Human immunodeficiency virus Humans Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Labor, Obstetric Medical sciences Nevirapine - administration & dosage Nevirapine - adverse effects Nevirapine - therapeutic use Pharmacology. Drug treatments Pregnancy Pregnancy Complications, Infectious - drug therapy Prenatal development Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - therapeutic use Viral Load
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