Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities

Hypersialylation of tumor cell surface proteins along with a marked upregulation of sialyltransferase (ST) activity is a well‐established hallmark of cancer. Due to the critical role of STs in tumor growth and progression, ST inhibition has emerged as a potential new antimetastatic strategy for a ra...

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Veröffentlicht in:	Medicinal research reviews 2017-03, Vol.37 (2), p.219-270
Hauptverfasser:	Szabo, Rémi, Skropeta, Danielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anticancer agents antimetastasis Carbohydrate Sequence diagnostic tools Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology High-Throughput Screening Assays - methods Humans Neoplasms - blood Neoplasms - drug therapy Neoplasms - enzymology Nervous System Diseases - drug therapy Nervous System Diseases - enzymology sialyltransferase inhibitors Sialyltransferases - antagonists & inhibitors Sialyltransferases - blood structure‐based design
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