Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy
Purpose The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear. Methods One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospec...
Gespeichert in:
| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2017-06, Vol.47 (6), p.697-704 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 704 |
|---|---|
| container_issue | 6 |
| container_start_page | 697 |
| container_title | Surgery today (Tokyo, Japan) |
| container_volume | 47 |
| creator | Kaneko, Kensuke Kawai, Kazushige Kazama, Shinsuke Murono, Koji Sasaki, Kazuhito Yasuda, Koji Ohtani, Kensuke Nishikawa, Takeshi Tanaka, Toshiaki Kiyomatsu, Tomomichi Hata, Keisuke Nozawa, Hiroaki Ishihara, Soichiro Morikawa, Teppei Fukayama, Masashi Watanabe, Toshiaki |
| description | Purpose
The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear.
Methods
One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospectively reviewed. Patients were classified into 3 groups according to the proportion of extracellular mucin: low (25 %).
Results
There were 82 (63.1 %), 26 (20.0 %), and 22 (16.9 %) patients in the low, moderate, and high mucin groups, respectively. Patients with a high mucinous tumor component were significantly more likely to have an advanced tumor stage (
p
= 0.010) and a shorter disease-free (
p
= 0.002) and distant recurrence-free survivals (
p
|
| doi_str_mv | 10.1007/s00595-016-1419-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859739460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859739460</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-429614aa9878ffd877a85a32546148d55c6fd39a2fbdf6ae5c3041ad0f7485fb3</originalsourceid><addsrcrecordid>eNp9kE1PxCAQhonR6Lr6A7yYHr1UBwotHM3Gr2QTL3omLIVdTAsVWpP997Lu6tHLMBmeeZN5ELrCcIsBmrsEwAQrAdclpliUcIRmmFZ1STiujtEMBMUlJgKfofOUPgAI5QCn6Iw0NRNEwAytFp3zTquuSG7tnc2t16YItugn7XyYUqFDPwRv_JgK54to9JjpHywWyo65DtGEwUQ1ui9T6I3pQ1StC-Mmz4btBTqxqkvm8vDO0fvjw9viuVy-Pr0s7pelrmo-lpSIGlOlBG-4tS1vGsWZqgijecxbxnRt20ooYletrZVhugKKVQu2oZzZVTVHN_vcIYbPyaRR9i5p03XKm3yHxJyJphK0hoziPapjSCkaK4foehW3EoPcqZV7tTKrlTu1crdzfYifVr1p_zZ-XWaA7IGUv_zaRPkRpujzyf-kfgP62YXj</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859739460</pqid></control><display><type>article</type><title>Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kaneko, Kensuke ; Kawai, Kazushige ; Kazama, Shinsuke ; Murono, Koji ; Sasaki, Kazuhito ; Yasuda, Koji ; Ohtani, Kensuke ; Nishikawa, Takeshi ; Tanaka, Toshiaki ; Kiyomatsu, Tomomichi ; Hata, Keisuke ; Nozawa, Hiroaki ; Ishihara, Soichiro ; Morikawa, Teppei ; Fukayama, Masashi ; Watanabe, Toshiaki</creator><creatorcontrib>Kaneko, Kensuke ; Kawai, Kazushige ; Kazama, Shinsuke ; Murono, Koji ; Sasaki, Kazuhito ; Yasuda, Koji ; Ohtani, Kensuke ; Nishikawa, Takeshi ; Tanaka, Toshiaki ; Kiyomatsu, Tomomichi ; Hata, Keisuke ; Nozawa, Hiroaki ; Ishihara, Soichiro ; Morikawa, Teppei ; Fukayama, Masashi ; Watanabe, Toshiaki</creatorcontrib><description>Purpose
The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear.
Methods
One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospectively reviewed. Patients were classified into 3 groups according to the proportion of extracellular mucin: low (<5 %), moderate (5–25 %), and high (>25 %).
Results
There were 82 (63.1 %), 26 (20.0 %), and 22 (16.9 %) patients in the low, moderate, and high mucin groups, respectively. Patients with a high mucinous tumor component were significantly more likely to have an advanced tumor stage (
p
= 0.010) and a shorter disease-free (
p
= 0.002) and distant recurrence-free survivals (
p
< 0.001), whereas the mucinous tumor component showed no correlation with local recurrence (
p
= 0.101). A high mucinous component was also an independent predictive factor for a shorter disease-free survival (
p
= 0.041, hazard ratio = 2.56) and distant recurrence-free survival (
p
= 0.001, hazard ratio = 5.74) according to a multivariate analysis.
Conclusions
Because the mucinous components showed little correlation with local recurrence, mucinous cancer should not be a determining factor for chemoradiotherapy. However, the frequent occurrence of metachronous distant metastasis among patients with a high mucin component makes this a possible indicator for more robust postoperative adjuvant treatment and close surveillance of recurrence.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-016-1419-0</identifier><identifier>PMID: 27659290</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Chemoradiotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mucins - analysis ; Neoadjuvant Therapy ; Original Article ; Predictive Value of Tests ; Preoperative Care ; Prognosis ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - metabolism ; Rectal Neoplasms - mortality ; Rectal Neoplasms - therapy ; Surgery ; Surgical Oncology</subject><ispartof>Surgery today (Tokyo, Japan), 2017-06, Vol.47 (6), p.697-704</ispartof><rights>Springer Japan 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-429614aa9878ffd877a85a32546148d55c6fd39a2fbdf6ae5c3041ad0f7485fb3</citedby><cites>FETCH-LOGICAL-c368t-429614aa9878ffd877a85a32546148d55c6fd39a2fbdf6ae5c3041ad0f7485fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-016-1419-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-016-1419-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27659290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaneko, Kensuke</creatorcontrib><creatorcontrib>Kawai, Kazushige</creatorcontrib><creatorcontrib>Kazama, Shinsuke</creatorcontrib><creatorcontrib>Murono, Koji</creatorcontrib><creatorcontrib>Sasaki, Kazuhito</creatorcontrib><creatorcontrib>Yasuda, Koji</creatorcontrib><creatorcontrib>Ohtani, Kensuke</creatorcontrib><creatorcontrib>Nishikawa, Takeshi</creatorcontrib><creatorcontrib>Tanaka, Toshiaki</creatorcontrib><creatorcontrib>Kiyomatsu, Tomomichi</creatorcontrib><creatorcontrib>Hata, Keisuke</creatorcontrib><creatorcontrib>Nozawa, Hiroaki</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Morikawa, Teppei</creatorcontrib><creatorcontrib>Fukayama, Masashi</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><title>Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear.
Methods
One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospectively reviewed. Patients were classified into 3 groups according to the proportion of extracellular mucin: low (<5 %), moderate (5–25 %), and high (>25 %).
Results
There were 82 (63.1 %), 26 (20.0 %), and 22 (16.9 %) patients in the low, moderate, and high mucin groups, respectively. Patients with a high mucinous tumor component were significantly more likely to have an advanced tumor stage (
p
= 0.010) and a shorter disease-free (
p
= 0.002) and distant recurrence-free survivals (
p
< 0.001), whereas the mucinous tumor component showed no correlation with local recurrence (
p
= 0.101). A high mucinous component was also an independent predictive factor for a shorter disease-free survival (
p
= 0.041, hazard ratio = 2.56) and distant recurrence-free survival (
p
= 0.001, hazard ratio = 5.74) according to a multivariate analysis.
Conclusions
Because the mucinous components showed little correlation with local recurrence, mucinous cancer should not be a determining factor for chemoradiotherapy. However, the frequent occurrence of metachronous distant metastasis among patients with a high mucin component makes this a possible indicator for more robust postoperative adjuvant treatment and close surveillance of recurrence.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mucins - analysis</subject><subject>Neoadjuvant Therapy</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - diagnosis</subject><subject>Rectal Neoplasms - metabolism</subject><subject>Rectal Neoplasms - mortality</subject><subject>Rectal Neoplasms - therapy</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PxCAQhonR6Lr6A7yYHr1UBwotHM3Gr2QTL3omLIVdTAsVWpP997Lu6tHLMBmeeZN5ELrCcIsBmrsEwAQrAdclpliUcIRmmFZ1STiujtEMBMUlJgKfofOUPgAI5QCn6Iw0NRNEwAytFp3zTquuSG7tnc2t16YItugn7XyYUqFDPwRv_JgK54to9JjpHywWyo65DtGEwUQ1ui9T6I3pQ1StC-Mmz4btBTqxqkvm8vDO0fvjw9viuVy-Pr0s7pelrmo-lpSIGlOlBG-4tS1vGsWZqgijecxbxnRt20ooYletrZVhugKKVQu2oZzZVTVHN_vcIYbPyaRR9i5p03XKm3yHxJyJphK0hoziPapjSCkaK4foehW3EoPcqZV7tTKrlTu1crdzfYifVr1p_zZ-XWaA7IGUv_zaRPkRpujzyf-kfgP62YXj</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Kaneko, Kensuke</creator><creator>Kawai, Kazushige</creator><creator>Kazama, Shinsuke</creator><creator>Murono, Koji</creator><creator>Sasaki, Kazuhito</creator><creator>Yasuda, Koji</creator><creator>Ohtani, Kensuke</creator><creator>Nishikawa, Takeshi</creator><creator>Tanaka, Toshiaki</creator><creator>Kiyomatsu, Tomomichi</creator><creator>Hata, Keisuke</creator><creator>Nozawa, Hiroaki</creator><creator>Ishihara, Soichiro</creator><creator>Morikawa, Teppei</creator><creator>Fukayama, Masashi</creator><creator>Watanabe, Toshiaki</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170601</creationdate><title>Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy</title><author>Kaneko, Kensuke ; Kawai, Kazushige ; Kazama, Shinsuke ; Murono, Koji ; Sasaki, Kazuhito ; Yasuda, Koji ; Ohtani, Kensuke ; Nishikawa, Takeshi ; Tanaka, Toshiaki ; Kiyomatsu, Tomomichi ; Hata, Keisuke ; Nozawa, Hiroaki ; Ishihara, Soichiro ; Morikawa, Teppei ; Fukayama, Masashi ; Watanabe, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-429614aa9878ffd877a85a32546148d55c6fd39a2fbdf6ae5c3041ad0f7485fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mucins - analysis</topic><topic>Neoadjuvant Therapy</topic><topic>Original Article</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - diagnosis</topic><topic>Rectal Neoplasms - metabolism</topic><topic>Rectal Neoplasms - mortality</topic><topic>Rectal Neoplasms - therapy</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaneko, Kensuke</creatorcontrib><creatorcontrib>Kawai, Kazushige</creatorcontrib><creatorcontrib>Kazama, Shinsuke</creatorcontrib><creatorcontrib>Murono, Koji</creatorcontrib><creatorcontrib>Sasaki, Kazuhito</creatorcontrib><creatorcontrib>Yasuda, Koji</creatorcontrib><creatorcontrib>Ohtani, Kensuke</creatorcontrib><creatorcontrib>Nishikawa, Takeshi</creatorcontrib><creatorcontrib>Tanaka, Toshiaki</creatorcontrib><creatorcontrib>Kiyomatsu, Tomomichi</creatorcontrib><creatorcontrib>Hata, Keisuke</creatorcontrib><creatorcontrib>Nozawa, Hiroaki</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Morikawa, Teppei</creatorcontrib><creatorcontrib>Fukayama, Masashi</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaneko, Kensuke</au><au>Kawai, Kazushige</au><au>Kazama, Shinsuke</au><au>Murono, Koji</au><au>Sasaki, Kazuhito</au><au>Yasuda, Koji</au><au>Ohtani, Kensuke</au><au>Nishikawa, Takeshi</au><au>Tanaka, Toshiaki</au><au>Kiyomatsu, Tomomichi</au><au>Hata, Keisuke</au><au>Nozawa, Hiroaki</au><au>Ishihara, Soichiro</au><au>Morikawa, Teppei</au><au>Fukayama, Masashi</au><au>Watanabe, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>47</volume><issue>6</issue><spage>697</spage><epage>704</epage><pages>697-704</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
The clinical implications of mucinous components in rectal tumors, especially with regard to the efficacy of neoadjuvant chemoradiotherapy, remain unclear.
Methods
One hundred and thirty rectal cancer patients who received curative resection after neoadjuvant chemoradiotherapy were retrospectively reviewed. Patients were classified into 3 groups according to the proportion of extracellular mucin: low (<5 %), moderate (5–25 %), and high (>25 %).
Results
There were 82 (63.1 %), 26 (20.0 %), and 22 (16.9 %) patients in the low, moderate, and high mucin groups, respectively. Patients with a high mucinous tumor component were significantly more likely to have an advanced tumor stage (
p
= 0.010) and a shorter disease-free (
p
= 0.002) and distant recurrence-free survivals (
p
< 0.001), whereas the mucinous tumor component showed no correlation with local recurrence (
p
= 0.101). A high mucinous component was also an independent predictive factor for a shorter disease-free survival (
p
= 0.041, hazard ratio = 2.56) and distant recurrence-free survival (
p
= 0.001, hazard ratio = 5.74) according to a multivariate analysis.
Conclusions
Because the mucinous components showed little correlation with local recurrence, mucinous cancer should not be a determining factor for chemoradiotherapy. However, the frequent occurrence of metachronous distant metastasis among patients with a high mucin component makes this a possible indicator for more robust postoperative adjuvant treatment and close surveillance of recurrence.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27659290</pmid><doi>10.1007/s00595-016-1419-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2017-06, Vol.47 (6), p.697-704 |
| issn | 0941-1291 1436-2813 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859739460 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Chemoradiotherapy, Adjuvant Disease-Free Survival Female Humans Male Medicine Medicine & Public Health Middle Aged Mucins - analysis Neoadjuvant Therapy Original Article Predictive Value of Tests Preoperative Care Prognosis Rectal Neoplasms - diagnosis Rectal Neoplasms - metabolism Rectal Neoplasms - mortality Rectal Neoplasms - therapy Surgery Surgical Oncology |
| title | Clinical significance of mucinous components in rectal cancer after preoperative chemoradiotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T04%3A21%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20significance%20of%20mucinous%20components%20in%20rectal%20cancer%20after%20preoperative%20chemoradiotherapy&rft.jtitle=Surgery%20today%20(Tokyo,%20Japan)&rft.au=Kaneko,%20Kensuke&rft.date=2017-06-01&rft.volume=47&rft.issue=6&rft.spage=697&rft.epage=704&rft.pages=697-704&rft.issn=0941-1291&rft.eissn=1436-2813&rft_id=info:doi/10.1007/s00595-016-1419-0&rft_dat=%3Cproquest_cross%3E1859739460%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859739460&rft_id=info:pmid/27659290&rfr_iscdi=true |