Risk Stratification for Invasive Fungal Infections in Patients with Hematological Malignancies: SEIFEM recommendations
Abstract Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and...
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| Veröffentlicht in: | Blood reviews 2017-03, Vol.31 (2), p.17-29 |
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| creator | Pagano, Livio Busca, Alessandro Candoni, Anna Cattaneo, Chiara Cesaro, Simone Fanci, Rosa Nadali, Gianpaolo Potenza, Leonardo Russo, Domenico Tumbarello, Mario Nosari, Annamaria Aversa, Franco Lessi, Federica Criscuolo, Marianna Farina, Francesca Tisi, Maria Chiara Turri, Gloria Barone, Angelica Spolzino, Angelica Del Principe, Maria Ilaria Quinto, Angela Maria Di Blasi, Roberta Maracci, Laura Nabergoj, Mitja Cambò, Benedetta Pegoraro, Anna Marchesi, Francesco Pascale, Silvia Passi, Angela Carlisi, Melania Polverelli, Nicola Beggia, Barbara Rambaldi, Benedetta Prezioso, Lucia Sanna, Marco |
| description | Abstract Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp. ) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy. |
| doi_str_mv | 10.1016/j.blre.2016.09.002 |
| format | Article |
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Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp. ) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy.</description><identifier>ISSN: 0268-960X</identifier><identifier>EISSN: 1532-1681</identifier><identifier>DOI: 10.1016/j.blre.2016.09.002</identifier><identifier>PMID: 27682882</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Disease Susceptibility ; Hematologic Neoplasms - complications ; Hematologic Neoplasms - pathology ; Hematologic Neoplasms - therapy ; Hematology, Oncology and Palliative Medicine ; Hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Humans ; Incidence ; Invasive Fungal Infections - epidemiology ; Invasive Fungal Infections - etiology ; Invasive Fungal Infections - mortality ; Leukemia ; Molds ; Risk ; Risk factors ; Yeast</subject><ispartof>Blood reviews, 2017-03, Vol.31 (2), p.17-29</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-f5592bd136045098bc8fc84d86875e097c66f53aae8ca213f672c081777b301e3</citedby><cites>FETCH-LOGICAL-c455t-f5592bd136045098bc8fc84d86875e097c66f53aae8ca213f672c081777b301e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0268960X16300753$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27682882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pagano, Livio</creatorcontrib><creatorcontrib>Busca, Alessandro</creatorcontrib><creatorcontrib>Candoni, Anna</creatorcontrib><creatorcontrib>Cattaneo, Chiara</creatorcontrib><creatorcontrib>Cesaro, Simone</creatorcontrib><creatorcontrib>Fanci, Rosa</creatorcontrib><creatorcontrib>Nadali, Gianpaolo</creatorcontrib><creatorcontrib>Potenza, Leonardo</creatorcontrib><creatorcontrib>Russo, Domenico</creatorcontrib><creatorcontrib>Tumbarello, Mario</creatorcontrib><creatorcontrib>Nosari, Annamaria</creatorcontrib><creatorcontrib>Aversa, Franco</creatorcontrib><creatorcontrib>Lessi, Federica</creatorcontrib><creatorcontrib>Criscuolo, Marianna</creatorcontrib><creatorcontrib>Farina, Francesca</creatorcontrib><creatorcontrib>Tisi, Maria Chiara</creatorcontrib><creatorcontrib>Turri, Gloria</creatorcontrib><creatorcontrib>Barone, Angelica</creatorcontrib><creatorcontrib>Spolzino, Angelica</creatorcontrib><creatorcontrib>Del Principe, Maria Ilaria</creatorcontrib><creatorcontrib>Quinto, Angela Maria</creatorcontrib><creatorcontrib>Di Blasi, Roberta</creatorcontrib><creatorcontrib>Maracci, Laura</creatorcontrib><creatorcontrib>Nabergoj, Mitja</creatorcontrib><creatorcontrib>Cambò, Benedetta</creatorcontrib><creatorcontrib>Pegoraro, Anna</creatorcontrib><creatorcontrib>Marchesi, Francesco</creatorcontrib><creatorcontrib>Pascale, Silvia</creatorcontrib><creatorcontrib>Passi, Angela</creatorcontrib><creatorcontrib>Carlisi, Melania</creatorcontrib><creatorcontrib>Polverelli, Nicola</creatorcontrib><creatorcontrib>Beggia, Barbara</creatorcontrib><creatorcontrib>Rambaldi, Benedetta</creatorcontrib><creatorcontrib>Prezioso, Lucia</creatorcontrib><creatorcontrib>Sanna, Marco</creatorcontrib><creatorcontrib>on behalf of SEIFEM (Sorveglianza Epidemiologica Infezioni Fungine nelle Emopatie Maligne) Group</creatorcontrib><creatorcontrib>Other Authors</creatorcontrib><creatorcontrib>SEIFEM (Sorveglianza Epidemiologica Infezioni Fungine nelle Emopatie Maligne) Group</creatorcontrib><title>Risk Stratification for Invasive Fungal Infections in Patients with Hematological Malignancies: SEIFEM recommendations</title><title>Blood reviews</title><addtitle>Blood Rev</addtitle><description>Abstract Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in immunocompromised patients. Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp. ) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy.</description><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Disease Susceptibility</subject><subject>Hematologic Neoplasms - complications</subject><subject>Hematologic Neoplasms - pathology</subject><subject>Hematologic Neoplasms - therapy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Humans</subject><subject>Incidence</subject><subject>Invasive Fungal Infections - epidemiology</subject><subject>Invasive Fungal Infections - etiology</subject><subject>Invasive Fungal Infections - mortality</subject><subject>Leukemia</subject><subject>Molds</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Yeast</subject><issn>0268-960X</issn><issn>1532-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtvEzEUhS0EoqHwB1ggL9nM4Ef8GISQUJXQSK1ABCR2luO5E5zO2K09E9R_j4cUFizY-Nq655wrfxehl5TUlFD55lDv-gQ1K_eaNDUh7BFaUMFZRaWmj9GCMKmrRpLvZ-hZzgdCSMOleorOmJKaac0W6PjF5xu8HZMdfeddOWPAXUx4E442-yPg9RT2ti_vDtzczdgH_LkIIYwZ__TjD3wJgx1jH_cloMfXtvf7YIPzkN_i7WqzXl3jBC4OA4T294T8HD3pbJ_hxUM9R9_Wq68Xl9XVp4-biw9XlVsKMVadEA3btZRLshSk0TunO6eXrZZaCSCNclJ2glsL2llGeScVc0RTpdSOEwr8HL0-5d6meDdBHs3gs4O-twHilA3VolFcN1IUKTtJXYo5J-jMbfKDTfeGEjPzNgcz8zYzb0MaU3gX06uH_Gk3QPvX8gdwEbw7CaD88ughmVy4BAetL0hG00b___z3_9hd78OM-QbuIR_ilELhZ6jJzBCznTc-L5xKTogSnP8CYx-nNg</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Pagano, Livio</creator><creator>Busca, Alessandro</creator><creator>Candoni, Anna</creator><creator>Cattaneo, Chiara</creator><creator>Cesaro, Simone</creator><creator>Fanci, Rosa</creator><creator>Nadali, Gianpaolo</creator><creator>Potenza, Leonardo</creator><creator>Russo, Domenico</creator><creator>Tumbarello, Mario</creator><creator>Nosari, Annamaria</creator><creator>Aversa, Franco</creator><creator>Lessi, Federica</creator><creator>Criscuolo, Marianna</creator><creator>Farina, Francesca</creator><creator>Tisi, Maria Chiara</creator><creator>Turri, Gloria</creator><creator>Barone, Angelica</creator><creator>Spolzino, Angelica</creator><creator>Del Principe, Maria Ilaria</creator><creator>Quinto, Angela Maria</creator><creator>Di Blasi, Roberta</creator><creator>Maracci, Laura</creator><creator>Nabergoj, Mitja</creator><creator>Cambò, Benedetta</creator><creator>Pegoraro, Anna</creator><creator>Marchesi, Francesco</creator><creator>Pascale, Silvia</creator><creator>Passi, Angela</creator><creator>Carlisi, Melania</creator><creator>Polverelli, Nicola</creator><creator>Beggia, Barbara</creator><creator>Rambaldi, Benedetta</creator><creator>Prezioso, Lucia</creator><creator>Sanna, Marco</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Risk Stratification for Invasive Fungal Infections in Patients with Hematological Malignancies: SEIFEM recommendations</title><author>Pagano, Livio ; Busca, Alessandro ; Candoni, Anna ; Cattaneo, Chiara ; Cesaro, Simone ; Fanci, Rosa ; Nadali, Gianpaolo ; Potenza, Leonardo ; Russo, Domenico ; Tumbarello, Mario ; Nosari, Annamaria ; Aversa, Franco ; Lessi, Federica ; Criscuolo, Marianna ; Farina, Francesca ; Tisi, Maria Chiara ; Turri, Gloria ; Barone, Angelica ; Spolzino, Angelica ; Del Principe, Maria Ilaria ; Quinto, Angela Maria ; Di Blasi, Roberta ; Maracci, Laura ; Nabergoj, Mitja ; Cambò, Benedetta ; Pegoraro, Anna ; Marchesi, Francesco ; Pascale, Silvia ; Passi, Angela ; Carlisi, Melania ; Polverelli, Nicola ; Beggia, Barbara ; Rambaldi, Benedetta ; Prezioso, Lucia ; Sanna, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-f5592bd136045098bc8fc84d86875e097c66f53aae8ca213f672c081777b301e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antineoplastic Combined Chemotherapy Protocols - 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Patients with hematological malignancies undergoing conventional chemotherapy, autologous or allogeneic hematopoietic stem cell transplantation are considered at high risk, and Aspergillus spp. represents the most frequently isolated micro-organisms. In the last years, attention has also been focused on other rare molds (e.g., Zygomycetes, Fusarium spp. ) responsible for devastating clinical manifestations. The extensive use of antifungal prophylaxis has reduced the infections from yeasts (e.g., candidemia) even though they are still associated with high mortality rates. This paper analyzes concurrent multiple predisposing factors that could favor the onset of fungal infections. Although neutropenia is common to almost all hematologic patients, other factors play a key role in specific patients, in particular in patients with AML or allogeneic HSCT recipients. Defining those patients at higher risk of IFIs may help to design the most appropriate diagnostic work-up and antifungal strategy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27682882</pmid><doi>10.1016/j.blre.2016.09.002</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Antineoplastic Combined Chemotherapy Protocols - adverse effects Disease Susceptibility Hematologic Neoplasms - complications Hematologic Neoplasms - pathology Hematologic Neoplasms - therapy Hematology, Oncology and Palliative Medicine Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Humans Incidence Invasive Fungal Infections - epidemiology Invasive Fungal Infections - etiology Invasive Fungal Infections - mortality Leukemia Molds Risk Risk factors Yeast |
| title | Risk Stratification for Invasive Fungal Infections in Patients with Hematological Malignancies: SEIFEM recommendations |
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