Thermal protein unfolding by differential scanning calorimetry and circular dichroism spectroscopy Two-state model versus sequential unfolding

Thermally-induced protein unfolding is commonly described with the two-state model. This model assumes only two types of protein molecules in solution, the native (N) and the denatured, unfolded (U) protein. In reality, protein unfolding is a multistep process, even if intermediate states are only s...

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Veröffentlicht in:	Quarterly reviews of biophysics 2016-01, Vol.49, p.e9-e9, Article e9
Hauptverfasser:	Seelig, Joachim, Schönfeld, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Review
Online-Zugang:	Volltext
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