Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study
Background Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV‐related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OP...
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| Veröffentlicht in: | ANZ journal of surgery 2018-04, Vol.88 (4), p.E278-E283 |
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| container_title | ANZ journal of surgery |
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| creator | Ou, Peter Gear, Kim Rahnama, Fahimeh Thomas, Stephen Nagappan, Radhika Kee, Dennis Waldvogel‐Thurlow, Sharon Jain, Ravi McIvor, Nick Izzard, Mark Douglas, Richard |
| description | Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV‐related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OPSCC with direct molecular HPV testing has been conducted in New Zealand.
Aims
To estimate the proportion of OPSCCs attributable to HPV infections in a New Zealand population with a validated HPV testing algorithm.
Methods
HPV‐status was determined by p16 immunohistochemistry and polymerase chain reaction (PCR) of both L1 and E6/7 genes on 55 OPSCCs diagnosed in 2010 and 2011 in Central and South Auckland. Baseline and survival analyses were performed according to HPV status.
Results
Forty‐one (75%) of OPSCC tumours had HPV infections. There was 98% concordance between p16 immunohistochemistry and real‐time E6/E7 PCR. After a median follow‐up period of 2.6 years, patients with OPSCC of HPV aetiology had more favourable outcomes compared to patients with HPV‐negative OPSCC (hazard ratio 0.14, P = 0.02) after adjustment for other variables.
Conclusion
This study highlights the significant role that HPV plays in the aetiology of OPSCC in New Zealand, and confirms the high rate of accuracy of p16 immunostaining. |
| doi_str_mv | 10.1111/ans.13759 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859736667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2020641844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-5aa48166a2d5fbe99fe212202e93c15d222a95a69c24214547dc1ea388bd8cb53</originalsourceid><addsrcrecordid>eNp1kD1PwzAURS0EolAY-APIEgsMLfFnYraq4ktCZQAWFuvFcWmqJA52A-q_xyWFAQkvz5LPu746CJ2QZEziuYQmjAlLhdpBB4RzMaJEpbvbO-GMDdBhCMskIVIqsY8GNJU8lZk8QK93XQ0NbqEtq8rV8FH6LmBoCuy8axfg182bhQqH9w5qF5-MrSpswJuyifgVBjyzn_g1Mpsl4xbOr3BYdcX6CO3NoQr2eDuH6OXm-nl6N3p4vL2fTh5GhgmmRgKAZ7EY0ELMc6vU3FJCaUKtYoaIglIKSoBUhnJKuOBpYYgFlmV5kZlcsCE673Nb7947G1a6LsOmJjQ2NtYkEyplUso0omd_0KXrfBPb6fhhIjnJOI_URU8Z70Lwdq5bX9ZRhSaJ3gjXUbj-Fh7Z021il9e2-CV_DEfgsgc-y8qu_0_Sk9lTH_kFbUmJww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2020641844</pqid></control><display><type>article</type><title>Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Ou, Peter ; Gear, Kim ; Rahnama, Fahimeh ; Thomas, Stephen ; Nagappan, Radhika ; Kee, Dennis ; Waldvogel‐Thurlow, Sharon ; Jain, Ravi ; McIvor, Nick ; Izzard, Mark ; Douglas, Richard</creator><creatorcontrib>Ou, Peter ; Gear, Kim ; Rahnama, Fahimeh ; Thomas, Stephen ; Nagappan, Radhika ; Kee, Dennis ; Waldvogel‐Thurlow, Sharon ; Jain, Ravi ; McIvor, Nick ; Izzard, Mark ; Douglas, Richard</creatorcontrib><description>Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV‐related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OPSCC with direct molecular HPV testing has been conducted in New Zealand.
Aims
To estimate the proportion of OPSCCs attributable to HPV infections in a New Zealand population with a validated HPV testing algorithm.
Methods
HPV‐status was determined by p16 immunohistochemistry and polymerase chain reaction (PCR) of both L1 and E6/7 genes on 55 OPSCCs diagnosed in 2010 and 2011 in Central and South Auckland. Baseline and survival analyses were performed according to HPV status.
Results
Forty‐one (75%) of OPSCC tumours had HPV infections. There was 98% concordance between p16 immunohistochemistry and real‐time E6/E7 PCR. After a median follow‐up period of 2.6 years, patients with OPSCC of HPV aetiology had more favourable outcomes compared to patients with HPV‐negative OPSCC (hazard ratio 0.14, P = 0.02) after adjustment for other variables.
Conclusion
This study highlights the significant role that HPV plays in the aetiology of OPSCC in New Zealand, and confirms the high rate of accuracy of p16 immunostaining.</description><identifier>ISSN: 1445-1433</identifier><identifier>EISSN: 1445-2197</identifier><identifier>DOI: 10.1111/ans.13759</identifier><identifier>PMID: 27647686</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>Adult ; Aged ; Algorithms ; Biomarkers - metabolism ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - virology ; Cohort analysis ; Cohort Studies ; Cyclin-Dependent Kinase Inhibitor p16 - metabolism ; Epidemiology ; Feasibility Studies ; Female ; Head & neck cancer ; HPV ; Human papillomavirus ; Humans ; Immunohistochemistry ; Incidence ; Infections ; Male ; Middle Aged ; New Zealand ; Oropharyngeal Neoplasms - diagnosis ; Oropharyngeal Neoplasms - epidemiology ; Oropharyngeal Neoplasms - virology ; oropharyngeal squamous cell carcinoma ; Oropharyngolaryngeal carcinoma ; p16 ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - complications ; Papillomavirus Infections - diagnosis ; Patients ; PCR ; Polymerase chain reaction ; Squamous cell carcinoma ; Survival Rate ; Test procedures ; Throat cancer ; Tumors</subject><ispartof>ANZ journal of surgery, 2018-04, Vol.88 (4), p.E278-E283</ispartof><rights>2016 Royal Australasian College of Surgeons</rights><rights>2016 Royal Australasian College of Surgeons.</rights><rights>2018 Royal Australasian College of Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-5aa48166a2d5fbe99fe212202e93c15d222a95a69c24214547dc1ea388bd8cb53</citedby><cites>FETCH-LOGICAL-c3539-5aa48166a2d5fbe99fe212202e93c15d222a95a69c24214547dc1ea388bd8cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fans.13759$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fans.13759$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27647686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ou, Peter</creatorcontrib><creatorcontrib>Gear, Kim</creatorcontrib><creatorcontrib>Rahnama, Fahimeh</creatorcontrib><creatorcontrib>Thomas, Stephen</creatorcontrib><creatorcontrib>Nagappan, Radhika</creatorcontrib><creatorcontrib>Kee, Dennis</creatorcontrib><creatorcontrib>Waldvogel‐Thurlow, Sharon</creatorcontrib><creatorcontrib>Jain, Ravi</creatorcontrib><creatorcontrib>McIvor, Nick</creatorcontrib><creatorcontrib>Izzard, Mark</creatorcontrib><creatorcontrib>Douglas, Richard</creatorcontrib><title>Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study</title><title>ANZ journal of surgery</title><addtitle>ANZ J Surg</addtitle><description>Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV‐related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OPSCC with direct molecular HPV testing has been conducted in New Zealand.
Aims
To estimate the proportion of OPSCCs attributable to HPV infections in a New Zealand population with a validated HPV testing algorithm.
Methods
HPV‐status was determined by p16 immunohistochemistry and polymerase chain reaction (PCR) of both L1 and E6/7 genes on 55 OPSCCs diagnosed in 2010 and 2011 in Central and South Auckland. Baseline and survival analyses were performed according to HPV status.
Results
Forty‐one (75%) of OPSCC tumours had HPV infections. There was 98% concordance between p16 immunohistochemistry and real‐time E6/E7 PCR. After a median follow‐up period of 2.6 years, patients with OPSCC of HPV aetiology had more favourable outcomes compared to patients with HPV‐negative OPSCC (hazard ratio 0.14, P = 0.02) after adjustment for other variables.
Conclusion
This study highlights the significant role that HPV plays in the aetiology of OPSCC in New Zealand, and confirms the high rate of accuracy of p16 immunostaining.</description><subject>Adult</subject><subject>Aged</subject><subject>Algorithms</subject><subject>Biomarkers - metabolism</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</subject><subject>Epidemiology</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>HPV</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Incidence</subject><subject>Infections</subject><subject>Male</subject><subject>Middle Aged</subject><subject>New Zealand</subject><subject>Oropharyngeal Neoplasms - diagnosis</subject><subject>Oropharyngeal Neoplasms - epidemiology</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>oropharyngeal squamous cell carcinoma</subject><subject>Oropharyngolaryngeal carcinoma</subject><subject>p16</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Patients</subject><subject>PCR</subject><subject>Polymerase chain reaction</subject><subject>Squamous cell carcinoma</subject><subject>Survival Rate</subject><subject>Test procedures</subject><subject>Throat cancer</subject><subject>Tumors</subject><issn>1445-1433</issn><issn>1445-2197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAURS0EolAY-APIEgsMLfFnYraq4ktCZQAWFuvFcWmqJA52A-q_xyWFAQkvz5LPu746CJ2QZEziuYQmjAlLhdpBB4RzMaJEpbvbO-GMDdBhCMskIVIqsY8GNJU8lZk8QK93XQ0NbqEtq8rV8FH6LmBoCuy8axfg182bhQqH9w5qF5-MrSpswJuyifgVBjyzn_g1Mpsl4xbOr3BYdcX6CO3NoQr2eDuH6OXm-nl6N3p4vL2fTh5GhgmmRgKAZ7EY0ELMc6vU3FJCaUKtYoaIglIKSoBUhnJKuOBpYYgFlmV5kZlcsCE673Nb7947G1a6LsOmJjQ2NtYkEyplUso0omd_0KXrfBPb6fhhIjnJOI_URU8Z70Lwdq5bX9ZRhSaJ3gjXUbj-Fh7Z021il9e2-CV_DEfgsgc-y8qu_0_Sk9lTH_kFbUmJww</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Ou, Peter</creator><creator>Gear, Kim</creator><creator>Rahnama, Fahimeh</creator><creator>Thomas, Stephen</creator><creator>Nagappan, Radhika</creator><creator>Kee, Dennis</creator><creator>Waldvogel‐Thurlow, Sharon</creator><creator>Jain, Ravi</creator><creator>McIvor, Nick</creator><creator>Izzard, Mark</creator><creator>Douglas, Richard</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study</title><author>Ou, Peter ; Gear, Kim ; Rahnama, Fahimeh ; Thomas, Stephen ; Nagappan, Radhika ; Kee, Dennis ; Waldvogel‐Thurlow, Sharon ; Jain, Ravi ; McIvor, Nick ; Izzard, Mark ; Douglas, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-5aa48166a2d5fbe99fe212202e93c15d222a95a69c24214547dc1ea388bd8cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Algorithms</topic><topic>Biomarkers - metabolism</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</topic><topic>Epidemiology</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>HPV</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Incidence</topic><topic>Infections</topic><topic>Male</topic><topic>Middle Aged</topic><topic>New Zealand</topic><topic>Oropharyngeal Neoplasms - diagnosis</topic><topic>Oropharyngeal Neoplasms - epidemiology</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>oropharyngeal squamous cell carcinoma</topic><topic>Oropharyngolaryngeal carcinoma</topic><topic>p16</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - diagnosis</topic><topic>Patients</topic><topic>PCR</topic><topic>Polymerase chain reaction</topic><topic>Squamous cell carcinoma</topic><topic>Survival Rate</topic><topic>Test procedures</topic><topic>Throat cancer</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ou, Peter</creatorcontrib><creatorcontrib>Gear, Kim</creatorcontrib><creatorcontrib>Rahnama, Fahimeh</creatorcontrib><creatorcontrib>Thomas, Stephen</creatorcontrib><creatorcontrib>Nagappan, Radhika</creatorcontrib><creatorcontrib>Kee, Dennis</creatorcontrib><creatorcontrib>Waldvogel‐Thurlow, Sharon</creatorcontrib><creatorcontrib>Jain, Ravi</creatorcontrib><creatorcontrib>McIvor, Nick</creatorcontrib><creatorcontrib>Izzard, Mark</creatorcontrib><creatorcontrib>Douglas, Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>ANZ journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ou, Peter</au><au>Gear, Kim</au><au>Rahnama, Fahimeh</au><au>Thomas, Stephen</au><au>Nagappan, Radhika</au><au>Kee, Dennis</au><au>Waldvogel‐Thurlow, Sharon</au><au>Jain, Ravi</au><au>McIvor, Nick</au><au>Izzard, Mark</au><au>Douglas, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study</atitle><jtitle>ANZ journal of surgery</jtitle><addtitle>ANZ J Surg</addtitle><date>2018-04</date><risdate>2018</risdate><volume>88</volume><issue>4</issue><spage>E278</spage><epage>E283</epage><pages>E278-E283</pages><issn>1445-1433</issn><eissn>1445-2197</eissn><abstract>Background
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinomas (OPSCC) are clinically, epidemiologically and prognostically distinct from other OPSCCs. The incidence of HPV‐related OPSCCs has increased significantly worldwide over the past few decades. However, no studies of OPSCC with direct molecular HPV testing has been conducted in New Zealand.
Aims
To estimate the proportion of OPSCCs attributable to HPV infections in a New Zealand population with a validated HPV testing algorithm.
Methods
HPV‐status was determined by p16 immunohistochemistry and polymerase chain reaction (PCR) of both L1 and E6/7 genes on 55 OPSCCs diagnosed in 2010 and 2011 in Central and South Auckland. Baseline and survival analyses were performed according to HPV status.
Results
Forty‐one (75%) of OPSCC tumours had HPV infections. There was 98% concordance between p16 immunohistochemistry and real‐time E6/E7 PCR. After a median follow‐up period of 2.6 years, patients with OPSCC of HPV aetiology had more favourable outcomes compared to patients with HPV‐negative OPSCC (hazard ratio 0.14, P = 0.02) after adjustment for other variables.
Conclusion
This study highlights the significant role that HPV plays in the aetiology of OPSCC in New Zealand, and confirms the high rate of accuracy of p16 immunostaining.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>27647686</pmid><doi>10.1111/ans.13759</doi><tpages>6</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adult Aged Algorithms Biomarkers - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - virology Cohort analysis Cohort Studies Cyclin-Dependent Kinase Inhibitor p16 - metabolism Epidemiology Feasibility Studies Female Head & neck cancer HPV Human papillomavirus Humans Immunohistochemistry Incidence Infections Male Middle Aged New Zealand Oropharyngeal Neoplasms - diagnosis Oropharyngeal Neoplasms - epidemiology Oropharyngeal Neoplasms - virology oropharyngeal squamous cell carcinoma Oropharyngolaryngeal carcinoma p16 Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Patients PCR Polymerase chain reaction Squamous cell carcinoma Survival Rate Test procedures Throat cancer Tumors |
| title | Human papillomavirus and oropharyngeal squamous cell carcinoma: a New Zealand cohort study |
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