UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity

In the current study, we have extended previous findings aiming at a better understanding of molecular mechanisms underlying UVB-induced senescence of diploid human dermal fibroblasts (HDFs), an experimental model to study the process of photoaging in the skin. We provide evidence that the inhibitio...

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Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2017-05, Vol.72 (5), p.632-639
Hauptverfasser: Cavinato, Maria, Koziel, Rafal, Romani, Nikolaus, Weinmüllner, Regina, Jenewein, Brigitte, Hermann, Martin, Dubrac, Sandrine, Ratzinger, Gudrun, Grillari, Johannes, Schmuth, Matthias, Jansen-Dürr, Pidder
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Sprache:eng
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