Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men
Summary The aim of this study was to assess the total antioxidant capacity (TAC) and malondialdehyde (MDA) level in infertile men with asthenozoospermia and asthenoteratozoospermia compared to fertile donors, and to examine the effect of zinc on sperm lipid peroxidation and antioxidant status in inf...
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| Veröffentlicht in: | Andrologia 2017-09, Vol.49 (7), p.e12703-n/a |
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| creator | Ajina, T. Sallem, A. Haouas, Z. Mehdi, M. |
| description | Summary
The aim of this study was to assess the total antioxidant capacity (TAC) and malondialdehyde (MDA) level in infertile men with asthenozoospermia and asthenoteratozoospermia compared to fertile donors, and to examine the effect of zinc on sperm lipid peroxidation and antioxidant status in infertile and fertile men. Semen samples provided by infertile men (n = 38) and fertile donors (controls; n = 12) were exposed to 6 mmol/L of zinc for 2 hr at 37°C. After semen analysis, lipid peroxidation was detected by MDA assay and seminal TAC was assessed by colorimetric method using TAS (total antioxidant status) Kit. TAC was significantly lower in infertile group compared to controls (p = .037). However, lipid peroxidation did not alter in infertile patients compared to controls (p > .05). After in vitro incubation of samples with zinc, a significant increase in TAC level was found only in infertile men (p .05). Our data indicate that antioxidant treatment based on zinc in vitro supplementation may be helpful to enhance the rate of seminal antioxidant status in infertile men; however, it does not prevent sperm lipid peroxidation. |
| doi_str_mv | 10.1111/and.12703 |
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The aim of this study was to assess the total antioxidant capacity (TAC) and malondialdehyde (MDA) level in infertile men with asthenozoospermia and asthenoteratozoospermia compared to fertile donors, and to examine the effect of zinc on sperm lipid peroxidation and antioxidant status in infertile and fertile men. Semen samples provided by infertile men (n = 38) and fertile donors (controls; n = 12) were exposed to 6 mmol/L of zinc for 2 hr at 37°C. After semen analysis, lipid peroxidation was detected by MDA assay and seminal TAC was assessed by colorimetric method using TAS (total antioxidant status) Kit. TAC was significantly lower in infertile group compared to controls (p = .037). However, lipid peroxidation did not alter in infertile patients compared to controls (p > .05). After in vitro incubation of samples with zinc, a significant increase in TAC level was found only in infertile men (p < .001). Meanwhile, zinc had no effect on sperm lipid peroxidation in both fertile and infertile men (p > .05). Our data indicate that antioxidant treatment based on zinc in vitro supplementation may be helpful to enhance the rate of seminal antioxidant status in infertile men; however, it does not prevent sperm lipid peroxidation.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.12703</identifier><identifier>PMID: 27686342</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Antioxidants ; Antioxidants - analysis ; Asthenozoospermia - drug therapy ; Asthenozoospermia - metabolism ; Colorimetry ; Humans ; Infertility, Male - drug therapy ; Infertility, Male - metabolism ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Male ; Malondialdehyde ; Malondialdehyde - analysis ; Semen ; Semen Analysis ; Sperm ; Spermatozoa - chemistry ; Spermatozoa - drug effects ; Supplements ; total antioxidant capacity ; Vitamin E ; Zinc ; Zinc - pharmacology</subject><ispartof>Andrologia, 2017-09, Vol.49 (7), p.e12703-n/a</ispartof><rights>2016 Blackwell Verlag GmbH</rights><rights>2016 Blackwell Verlag GmbH.</rights><rights>Copyright © 2017 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-f78ff7d7cb50000bd06433c447c1d15f7676173a868696165b8d29d86e15a4c3</citedby><cites>FETCH-LOGICAL-c3883-f78ff7d7cb50000bd06433c447c1d15f7676173a868696165b8d29d86e15a4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.12703$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.12703$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27686342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajina, T.</creatorcontrib><creatorcontrib>Sallem, A.</creatorcontrib><creatorcontrib>Haouas, Z.</creatorcontrib><creatorcontrib>Mehdi, M.</creatorcontrib><title>Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Summary
The aim of this study was to assess the total antioxidant capacity (TAC) and malondialdehyde (MDA) level in infertile men with asthenozoospermia and asthenoteratozoospermia compared to fertile donors, and to examine the effect of zinc on sperm lipid peroxidation and antioxidant status in infertile and fertile men. Semen samples provided by infertile men (n = 38) and fertile donors (controls; n = 12) were exposed to 6 mmol/L of zinc for 2 hr at 37°C. After semen analysis, lipid peroxidation was detected by MDA assay and seminal TAC was assessed by colorimetric method using TAS (total antioxidant status) Kit. TAC was significantly lower in infertile group compared to controls (p = .037). However, lipid peroxidation did not alter in infertile patients compared to controls (p > .05). After in vitro incubation of samples with zinc, a significant increase in TAC level was found only in infertile men (p < .001). Meanwhile, zinc had no effect on sperm lipid peroxidation in both fertile and infertile men (p > .05). Our data indicate that antioxidant treatment based on zinc in vitro supplementation may be helpful to enhance the rate of seminal antioxidant status in infertile men; however, it does not prevent sperm lipid peroxidation.</description><subject>Antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Asthenozoospermia - drug therapy</subject><subject>Asthenozoospermia - metabolism</subject><subject>Colorimetry</subject><subject>Humans</subject><subject>Infertility, Male - drug therapy</subject><subject>Infertility, Male - metabolism</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Male</subject><subject>Malondialdehyde</subject><subject>Malondialdehyde - analysis</subject><subject>Semen</subject><subject>Semen Analysis</subject><subject>Sperm</subject><subject>Spermatozoa - chemistry</subject><subject>Spermatozoa - drug effects</subject><subject>Supplements</subject><subject>total antioxidant capacity</subject><subject>Vitamin E</subject><subject>Zinc</subject><subject>Zinc - pharmacology</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1LxDAQhoMouqgH_4AEvOiha76apMdl_QTRy95Dtkkx0m1qkrrqrze7VQ-CQ2CGmYeXyTsAnGA0xTkudWemmAhEd8AEM1oViAiyCyaIIlqwklcH4DjGF5SDlUIwtg8OiOCSU0YmwC980i3UXXL-3ZmcYUw6DTG3DGxd7wzsbdjOMtLBtUvP29mm8EOCroNvLgUPP11Xwzj0fWtXtksj7javsSG51sLcPgJ7jW6jPf7Oh2Bxc72Y3xUPT7f389lDUVMpadEI2TTCiHpZbhZfGsQZpTVjosYGl43ggmNBtcz_qDjm5VIaUhnJLS41q-khOB9l--BfBxuTWrlY27bVnfVDVFiWlcgGEJzRsz_oix9Cl5dTuCKCSkERydTFSNXBxxhso_rgVjp8KIzU5g4qe6K2d8js6bfisFxZ80v-uJ6ByxFYZ1c-_ldSs8erUfIL3AORiw</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Ajina, T.</creator><creator>Sallem, A.</creator><creator>Haouas, Z.</creator><creator>Mehdi, M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201709</creationdate><title>Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men</title><author>Ajina, T. ; Sallem, A. ; Haouas, Z. ; Mehdi, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-f78ff7d7cb50000bd06433c447c1d15f7676173a868696165b8d29d86e15a4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Asthenozoospermia - drug therapy</topic><topic>Asthenozoospermia - metabolism</topic><topic>Colorimetry</topic><topic>Humans</topic><topic>Infertility, Male - drug therapy</topic><topic>Infertility, Male - metabolism</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Male</topic><topic>Malondialdehyde</topic><topic>Malondialdehyde - analysis</topic><topic>Semen</topic><topic>Semen Analysis</topic><topic>Sperm</topic><topic>Spermatozoa - chemistry</topic><topic>Spermatozoa - drug effects</topic><topic>Supplements</topic><topic>total antioxidant capacity</topic><topic>Vitamin E</topic><topic>Zinc</topic><topic>Zinc - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajina, T.</creatorcontrib><creatorcontrib>Sallem, A.</creatorcontrib><creatorcontrib>Haouas, Z.</creatorcontrib><creatorcontrib>Mehdi, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajina, T.</au><au>Sallem, A.</au><au>Haouas, Z.</au><au>Mehdi, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2017-09</date><risdate>2017</risdate><volume>49</volume><issue>7</issue><spage>e12703</spage><epage>n/a</epage><pages>e12703-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Summary
The aim of this study was to assess the total antioxidant capacity (TAC) and malondialdehyde (MDA) level in infertile men with asthenozoospermia and asthenoteratozoospermia compared to fertile donors, and to examine the effect of zinc on sperm lipid peroxidation and antioxidant status in infertile and fertile men. Semen samples provided by infertile men (n = 38) and fertile donors (controls; n = 12) were exposed to 6 mmol/L of zinc for 2 hr at 37°C. After semen analysis, lipid peroxidation was detected by MDA assay and seminal TAC was assessed by colorimetric method using TAS (total antioxidant status) Kit. TAC was significantly lower in infertile group compared to controls (p = .037). However, lipid peroxidation did not alter in infertile patients compared to controls (p > .05). After in vitro incubation of samples with zinc, a significant increase in TAC level was found only in infertile men (p < .001). Meanwhile, zinc had no effect on sperm lipid peroxidation in both fertile and infertile men (p > .05). Our data indicate that antioxidant treatment based on zinc in vitro supplementation may be helpful to enhance the rate of seminal antioxidant status in infertile men; however, it does not prevent sperm lipid peroxidation.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27686342</pmid><doi>10.1111/and.12703</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Antioxidants - analysis Asthenozoospermia - drug therapy Asthenozoospermia - metabolism Colorimetry Humans Infertility, Male - drug therapy Infertility, Male - metabolism Lipid peroxidation Lipid Peroxidation - drug effects Lipids Male Malondialdehyde Malondialdehyde - analysis Semen Semen Analysis Sperm Spermatozoa - chemistry Spermatozoa - drug effects Supplements total antioxidant capacity Vitamin E Zinc Zinc - pharmacology |
| title | Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men |
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