Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population
The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 and TSPYL6 associa...
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| Veröffentlicht in: | Molecular neurobiology 2017-10, Vol.54 (8), p.5988-5995 |
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| creator | Liang, Yiqian Zhang, Rui Zhang, Shuo Ji, Guofa Shi, Puyu Yang, Tian Liu, Feng Feng, Jing Li, Chunqi Guo, Dangshe Chen, Mingwei |
| description | The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within
ACYP2
and
TSPYL6
associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in
ACYP2
and
TSPYL6
genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both
ACYP2
and
TSPYL6
, and rs17045754 in
ACYP2
gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between
ACYP2
and
TSPYL6
SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of
ACYP2
and
TSPYL6
are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings. |
| doi_str_mv | 10.1007/s12035-016-0086-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859732778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859732778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f0ad8e65486537950494aba378e301756f4c2f43d460665f1cb1480480a4c6ba3</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhkVpaJy0P6CXIuill21H39qjMW0SMNTk45CTkGVtrWRXcqVdmvz7yHVaSiEwMId53neGeRF6T-AzAVBfCqHARANENgBaNg-v0IwI0TaEaPoazUC3rFGS62N0UsodAKUE1Bt0TJXUEpSeoX5eSnLBjiFFnDo8X9yuKLZxg6-vVrdLic989GNweJX6xyHl3TaUoeBfYdziy1Du95qL4rZ-qMzVmNO9xyHicxvxYhuiL74qd1P_e8FbdNTZvvh3z_0U3Xz7er04b5bfzy4W82XjmKJj04HdaC8F11Iw1QrgLbdry5T2DIgSsuOOdpxtuAQpRUfcmnANtSx3soKn6NPBd5fTz8mX0QyhON_3Nvo0FUO0aBWjSumKfvwPvUtTjvU6Q1omSEulYpUiB8rlVEr2ndnlMNj8aAiYfRTmEIWpUZh9FOahaj48O0_rwW_-Kv78vgL0AJQ6ij98_mf1i65PECKSIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1935192673</pqid></control><display><type>article</type><title>Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Liang, Yiqian ; Zhang, Rui ; Zhang, Shuo ; Ji, Guofa ; Shi, Puyu ; Yang, Tian ; Liu, Feng ; Feng, Jing ; Li, Chunqi ; Guo, Dangshe ; Chen, Mingwei</creator><creatorcontrib>Liang, Yiqian ; Zhang, Rui ; Zhang, Shuo ; Ji, Guofa ; Shi, Puyu ; Yang, Tian ; Liu, Feng ; Feng, Jing ; Li, Chunqi ; Guo, Dangshe ; Chen, Mingwei</creatorcontrib><description>The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within
ACYP2
and
TSPYL6
associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in
ACYP2
and
TSPYL6
genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both
ACYP2
and
TSPYL6
, and rs17045754 in
ACYP2
gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between
ACYP2
and
TSPYL6
SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of
ACYP2
and
TSPYL6
are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-016-0086-x</identifier><identifier>PMID: 27686078</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acid Anhydride Hydrolases - genetics ; Aged ; Asian Continental Ancestry Group - genetics ; Biomedical and Life Sciences ; Biomedicine ; Brain Ischemia - genetics ; Cell Biology ; Diuretics ; Female ; Genetic Predisposition to Disease ; Genetics ; Haplotypes ; Health risks ; Humans ; Ischemia ; Linkage disequilibrium ; Male ; Middle Aged ; Neurobiology ; Neurology ; Neurosciences ; Nuclear Proteins - genetics ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Population ; Population genetics ; Risk ; Single-nucleotide polymorphism ; Stroke ; Stroke - genetics</subject><ispartof>Molecular neurobiology, 2017-10, Vol.54 (8), p.5988-5995</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Molecular Neurobiology is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f0ad8e65486537950494aba378e301756f4c2f43d460665f1cb1480480a4c6ba3</citedby><cites>FETCH-LOGICAL-c372t-f0ad8e65486537950494aba378e301756f4c2f43d460665f1cb1480480a4c6ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-016-0086-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-016-0086-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27686078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Yiqian</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Zhang, Shuo</creatorcontrib><creatorcontrib>Ji, Guofa</creatorcontrib><creatorcontrib>Shi, Puyu</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Feng, Jing</creatorcontrib><creatorcontrib>Li, Chunqi</creatorcontrib><creatorcontrib>Guo, Dangshe</creatorcontrib><creatorcontrib>Chen, Mingwei</creatorcontrib><title>Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within
ACYP2
and
TSPYL6
associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in
ACYP2
and
TSPYL6
genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both
ACYP2
and
TSPYL6
, and rs17045754 in
ACYP2
gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between
ACYP2
and
TSPYL6
SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of
ACYP2
and
TSPYL6
are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings.</description><subject>Acid Anhydride Hydrolases - genetics</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Ischemia - genetics</subject><subject>Cell Biology</subject><subject>Diuretics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Haplotypes</subject><subject>Health risks</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Linkage disequilibrium</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Nuclear Proteins - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population</subject><subject>Population genetics</subject><subject>Risk</subject><subject>Single-nucleotide polymorphism</subject><subject>Stroke</subject><subject>Stroke - 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genetics</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Ischemia - genetics</topic><topic>Cell Biology</topic><topic>Diuretics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Haplotypes</topic><topic>Health risks</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Linkage disequilibrium</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Nuclear Proteins - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population</topic><topic>Population genetics</topic><topic>Risk</topic><topic>Single-nucleotide polymorphism</topic><topic>Stroke</topic><topic>Stroke - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Yiqian</creatorcontrib><creatorcontrib>Zhang, Rui</creatorcontrib><creatorcontrib>Zhang, Shuo</creatorcontrib><creatorcontrib>Ji, Guofa</creatorcontrib><creatorcontrib>Shi, Puyu</creatorcontrib><creatorcontrib>Yang, Tian</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Feng, Jing</creatorcontrib><creatorcontrib>Li, Chunqi</creatorcontrib><creatorcontrib>Guo, Dangshe</creatorcontrib><creatorcontrib>Chen, Mingwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Yiqian</au><au>Zhang, Rui</au><au>Zhang, Shuo</au><au>Ji, Guofa</au><au>Shi, Puyu</au><au>Yang, Tian</au><au>Liu, Feng</au><au>Feng, Jing</au><au>Li, Chunqi</au><au>Guo, Dangshe</au><au>Chen, Mingwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>54</volume><issue>8</issue><spage>5988</spage><epage>5995</epage><pages>5988-5995</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>The development of ischemic stroke is associated with advanced age. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within
ACYP2
and
TSPYL6
associated with shorter telomere length. The objective of this study is to investigate the putative association of ischemic stroke with common polymorphisms in
ACYP2
and
TSPYL6
genes in a Chinese Han population. We found that the risk alleles of six single nucleotide polymorphisms (SNPs), including rs11125529, rs12615793, rs843711, rs11896604, and rs843706 within both
ACYP2
and
TSPYL6
, and rs17045754 in
ACYP2
gene, were related with increased risk of ischemic stroke according to both allelic and genotype association analyses. The significant correlations between
ACYP2
and
TSPYL6
SNPs and ischemic stroke risk were also observed in dominant, recessive, and additive models, respectively. Two blocks in high linkage disequilibrium were identified in this study, and two haplotypes were associated with higher ischemic stroke susceptibility. In conclusion, the genetic polymorphisms of
ACYP2
and
TSPYL6
are associated with increased risk of developing ischemic stroke. Further studies with larger sample sizes are required to validate our findings.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27686078</pmid><doi>10.1007/s12035-016-0086-x</doi><tpages>8</tpages></addata></record> |
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| subjects | Acid Anhydride Hydrolases - genetics Aged Asian Continental Ancestry Group - genetics Biomedical and Life Sciences Biomedicine Brain Ischemia - genetics Cell Biology Diuretics Female Genetic Predisposition to Disease Genetics Haplotypes Health risks Humans Ischemia Linkage disequilibrium Male Middle Aged Neurobiology Neurology Neurosciences Nuclear Proteins - genetics Polymorphism Polymorphism, Single Nucleotide - genetics Population Population genetics Risk Single-nucleotide polymorphism Stroke Stroke - genetics |
| title | Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population |
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