The effects of a multigrowth factor‐containing cream on recovery after laser treatment: a double‐blinded, randomized, split‐face controlled study
Summary Background Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor‐containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient. Aims We...
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| Veröffentlicht in: | Journal of cosmetic dermatology 2017-03, Vol.16 (1), p.76-83 |
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| container_title | Journal of cosmetic dermatology |
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| creator | Shin, Sungsik Shin, Jung U Lee, Youngin Kwon, Tae Gwang Lee, Ju Hee |
| description | Summary
Background
Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor‐containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient.
Aims
We performed a randomized controlled split‐face study to assess the effects of a multigrowth factor (MGF)‐containing cream on patients recovering from laser treatment.
Materials and Methods
Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF‐containing cream or control cream. We measured post‐treatment erythema and pigmentation using the erythema and melanin indices, respectively, and evaluated the total area of microcrusts with dermoscopy. Additionally, patient satisfaction levels and global improvement scores were assessed.
Results
We found that the area of microcrusts was significantly smaller in the MGF‐treated regions. Global improvement scores for post‐treatment edema and wrinkles were also significantly higher for MGF cream‐treated sides than for the control sides.
Conclusion
The MGF cream‐treated regions showed a more rapid recovery from crusts and edema. Thus, the use of an MGF‐containing cream after laser treatment can effectively reduce recovery time. |
| doi_str_mv | 10.1111/jocd.12285 |
| format | Article |
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Background
Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor‐containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient.
Aims
We performed a randomized controlled split‐face study to assess the effects of a multigrowth factor (MGF)‐containing cream on patients recovering from laser treatment.
Materials and Methods
Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF‐containing cream or control cream. We measured post‐treatment erythema and pigmentation using the erythema and melanin indices, respectively, and evaluated the total area of microcrusts with dermoscopy. Additionally, patient satisfaction levels and global improvement scores were assessed.
Results
We found that the area of microcrusts was significantly smaller in the MGF‐treated regions. Global improvement scores for post‐treatment edema and wrinkles were also significantly higher for MGF cream‐treated sides than for the control sides.
Conclusion
The MGF cream‐treated regions showed a more rapid recovery from crusts and edema. Thus, the use of an MGF‐containing cream after laser treatment can effectively reduce recovery time.</description><identifier>ISSN: 1473-2130</identifier><identifier>EISSN: 1473-2165</identifier><identifier>DOI: 10.1111/jocd.12285</identifier><identifier>PMID: 27633651</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; cosmeceutical ; Cosmetic Techniques - adverse effects ; Dermoscopy ; Double-Blind Method ; Drug Combinations ; Edema - drug therapy ; Edema - etiology ; Epidermal Growth Factor - therapeutic use ; Erythema - drug therapy ; Erythema - etiology ; Face ; Female ; Fibroblast Growth Factors - therapeutic use ; growth factor ; Humans ; Intercellular Signaling Peptides and Proteins - therapeutic use ; laser treatment ; Lasers, Gas - adverse effects ; Male ; Middle Aged ; Patient Satisfaction ; Photography ; Pigmentation Disorders - drug therapy ; Pigmentation Disorders - etiology ; Platelet-Derived Growth Factor - therapeutic use ; Prospective Studies ; Skin Aging ; Skin Cream ; Vascular Endothelial Growth Factor A - therapeutic use ; Wound Healing - drug effects ; Young Adult</subject><ispartof>Journal of cosmetic dermatology, 2017-03, Vol.16 (1), p.76-83</ispartof><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3295-9b1d1f9c5135f3390b1dee95d5c4dd8c5d0d839cd6cecb9db0e671985140e2bf3</citedby><cites>FETCH-LOGICAL-c3295-9b1d1f9c5135f3390b1dee95d5c4dd8c5d0d839cd6cecb9db0e671985140e2bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocd.12285$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocd.12285$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27633651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Sungsik</creatorcontrib><creatorcontrib>Shin, Jung U</creatorcontrib><creatorcontrib>Lee, Youngin</creatorcontrib><creatorcontrib>Kwon, Tae Gwang</creatorcontrib><creatorcontrib>Lee, Ju Hee</creatorcontrib><title>The effects of a multigrowth factor‐containing cream on recovery after laser treatment: a double‐blinded, randomized, split‐face controlled study</title><title>Journal of cosmetic dermatology</title><addtitle>J Cosmet Dermatol</addtitle><description>Summary
Background
Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor‐containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient.
Aims
We performed a randomized controlled split‐face study to assess the effects of a multigrowth factor (MGF)‐containing cream on patients recovering from laser treatment.
Materials and Methods
Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF‐containing cream or control cream. We measured post‐treatment erythema and pigmentation using the erythema and melanin indices, respectively, and evaluated the total area of microcrusts with dermoscopy. Additionally, patient satisfaction levels and global improvement scores were assessed.
Results
We found that the area of microcrusts was significantly smaller in the MGF‐treated regions. Global improvement scores for post‐treatment edema and wrinkles were also significantly higher for MGF cream‐treated sides than for the control sides.
Conclusion
The MGF cream‐treated regions showed a more rapid recovery from crusts and edema. Thus, the use of an MGF‐containing cream after laser treatment can effectively reduce recovery time.</description><subject>Adult</subject><subject>cosmeceutical</subject><subject>Cosmetic Techniques - adverse effects</subject><subject>Dermoscopy</subject><subject>Double-Blind Method</subject><subject>Drug Combinations</subject><subject>Edema - drug therapy</subject><subject>Edema - etiology</subject><subject>Epidermal Growth Factor - therapeutic use</subject><subject>Erythema - drug therapy</subject><subject>Erythema - etiology</subject><subject>Face</subject><subject>Female</subject><subject>Fibroblast Growth Factors - therapeutic use</subject><subject>growth factor</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - therapeutic use</subject><subject>laser treatment</subject><subject>Lasers, Gas - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Patient Satisfaction</subject><subject>Photography</subject><subject>Pigmentation Disorders - drug therapy</subject><subject>Pigmentation Disorders - etiology</subject><subject>Platelet-Derived Growth Factor - therapeutic use</subject><subject>Prospective Studies</subject><subject>Skin Aging</subject><subject>Skin Cream</subject><subject>Vascular Endothelial Growth Factor A - therapeutic use</subject><subject>Wound Healing - drug effects</subject><subject>Young Adult</subject><issn>1473-2130</issn><issn>1473-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uEzEQhy1ERULhwgMgHxEixbOOd9fcUKD_FKmXcl557XHryLsOtpcqnHgEbrwfT1KnKT3igz3WfP5G8o-QN8BOoKyPm6DNCVRVK56ROSwbvqigFs-fas5m5GVKG8agkSBekFnV1JzXAubkz_UtUrQWdU40WKroMPnsbmK4y7fUKp1D_Pvrtw5jVm504w3VEdVAw0gj6vAD444qmzFSr1LZc-nmAcf8qahMmHqP5Xnv3WjQfKBRjSYM7ue-TlvvcmmWIUj3A2LwHg1NeTK7V-TIKp_w9eN5TL6dfr1enS_WV2cXq8_rheaVFAvZgwErtQAuLOeSlTuiFEbopTGtFoaZlkttao26l6ZnWDcgWwFLhlVv-TF5d_BuY_g-Ycrd4JJG79WIYUodtEI2lQRZF_T9AdUxpBTRdtvoBhV3HbBuH0S3D6J7CKLAbx-9Uz-geUL__XwB4ADcOY-7_6i6y6vVl4P0HsodmeQ</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Shin, Sungsik</creator><creator>Shin, Jung U</creator><creator>Lee, Youngin</creator><creator>Kwon, Tae Gwang</creator><creator>Lee, Ju Hee</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>The effects of a multigrowth factor‐containing cream on recovery after laser treatment: a double‐blinded, randomized, split‐face controlled study</title><author>Shin, Sungsik ; Shin, Jung U ; Lee, Youngin ; Kwon, Tae Gwang ; Lee, Ju Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3295-9b1d1f9c5135f3390b1dee95d5c4dd8c5d0d839cd6cecb9db0e671985140e2bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>cosmeceutical</topic><topic>Cosmetic Techniques - adverse effects</topic><topic>Dermoscopy</topic><topic>Double-Blind Method</topic><topic>Drug Combinations</topic><topic>Edema - drug therapy</topic><topic>Edema - etiology</topic><topic>Epidermal Growth Factor - therapeutic use</topic><topic>Erythema - drug therapy</topic><topic>Erythema - etiology</topic><topic>Face</topic><topic>Female</topic><topic>Fibroblast Growth Factors - therapeutic use</topic><topic>growth factor</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - therapeutic use</topic><topic>laser treatment</topic><topic>Lasers, Gas - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Patient Satisfaction</topic><topic>Photography</topic><topic>Pigmentation Disorders - drug therapy</topic><topic>Pigmentation Disorders - etiology</topic><topic>Platelet-Derived Growth Factor - therapeutic use</topic><topic>Prospective Studies</topic><topic>Skin Aging</topic><topic>Skin Cream</topic><topic>Vascular Endothelial Growth Factor A - therapeutic use</topic><topic>Wound Healing - drug effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shin, Sungsik</creatorcontrib><creatorcontrib>Shin, Jung U</creatorcontrib><creatorcontrib>Lee, Youngin</creatorcontrib><creatorcontrib>Kwon, Tae Gwang</creatorcontrib><creatorcontrib>Lee, Ju Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cosmetic dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Sungsik</au><au>Shin, Jung U</au><au>Lee, Youngin</au><au>Kwon, Tae Gwang</au><au>Lee, Ju Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of a multigrowth factor‐containing cream on recovery after laser treatment: a double‐blinded, randomized, split‐face controlled study</atitle><jtitle>Journal of cosmetic dermatology</jtitle><addtitle>J Cosmet Dermatol</addtitle><date>2017-03</date><risdate>2017</risdate><volume>16</volume><issue>1</issue><spage>76</spage><epage>83</epage><pages>76-83</pages><issn>1473-2130</issn><eissn>1473-2165</eissn><abstract>Summary
Background
Patients who receive laser treatments may experience transient erythema, edema, and crusts for several days. Although a variety of growth factor‐containing creams for promoting recovery after laser treatment are available, evidence for their efficacy remains insufficient.
Aims
We performed a randomized controlled split‐face study to assess the effects of a multigrowth factor (MGF)‐containing cream on patients recovering from laser treatment.
Materials and Methods
Twenty patients underwent treatment using an ablative fractional laser and were randomized with respect to the side of the face treated with an MGF‐containing cream or control cream. We measured post‐treatment erythema and pigmentation using the erythema and melanin indices, respectively, and evaluated the total area of microcrusts with dermoscopy. Additionally, patient satisfaction levels and global improvement scores were assessed.
Results
We found that the area of microcrusts was significantly smaller in the MGF‐treated regions. Global improvement scores for post‐treatment edema and wrinkles were also significantly higher for MGF cream‐treated sides than for the control sides.
Conclusion
The MGF cream‐treated regions showed a more rapid recovery from crusts and edema. Thus, the use of an MGF‐containing cream after laser treatment can effectively reduce recovery time.</abstract><cop>England</cop><pmid>27633651</pmid><doi>10.1111/jocd.12285</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult cosmeceutical Cosmetic Techniques - adverse effects Dermoscopy Double-Blind Method Drug Combinations Edema - drug therapy Edema - etiology Epidermal Growth Factor - therapeutic use Erythema - drug therapy Erythema - etiology Face Female Fibroblast Growth Factors - therapeutic use growth factor Humans Intercellular Signaling Peptides and Proteins - therapeutic use laser treatment Lasers, Gas - adverse effects Male Middle Aged Patient Satisfaction Photography Pigmentation Disorders - drug therapy Pigmentation Disorders - etiology Platelet-Derived Growth Factor - therapeutic use Prospective Studies Skin Aging Skin Cream Vascular Endothelial Growth Factor A - therapeutic use Wound Healing - drug effects Young Adult |
| title | The effects of a multigrowth factor‐containing cream on recovery after laser treatment: a double‐blinded, randomized, split‐face controlled study |
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