Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress

The rapidly increasing prevalence of nonalcoholic fatty liver disease (NAFLD) has become one of the major public health threats in China and worldwide. However, during the development of NAFLD, the key mechanism underlying the progression of related fibrosis remains unclear, which greatly impedes th...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine 2017-02, Vol.180, p.103-117.e4
Hauptverfasser:	Li, Bing-Hang, He, Fang-Ping, Yang, Xin, Chen, Yuan-Wen, Fan, Jian-Gao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Case-Control Studies Chemokine CCL5 - blood Chemokine CCL5 - genetics Chemokine CCL5 - metabolism Disease Progression Female Gene Knockdown Techniques Humans Internal Medicine Liver - metabolism Liver - pathology Liver Cirrhosis - blood Liver Cirrhosis - complications Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Male Middle Aged Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Promoter Regions, Genetic - genetics Rats, Wistar RNA, Messenger - genetics RNA, Messenger - metabolism Staining and Labeling Transcription Factors - metabolism
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