Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran
Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resist...
Gespeichert in:
| Veröffentlicht in: | Japanese Journal of Infectious Diseases 2017, Vol.70(3), pp.235-238 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 238 |
|---|---|
| container_issue | 3 |
| container_start_page | 235 |
| container_title | Japanese Journal of Infectious Diseases |
| container_volume | 70 |
| creator | Asadi, Fatemeh Torkaman Hashemi, Seyyed Hamid Alikhani, Mohammad Yousef Moghimbeigi, Abbas Naseri, Zahra |
| description | Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinical isolates to 7 antibiotics was assessed by the E-test method. One hundred forty-nine patients with brucellosis were evaluated. 38.3% of cultures of clinical samples were positive for BACTEC system, of which 91.2% were associated with a positive serological test result. No significant associations were found between serology and the culture method. All Brucella isolates were susceptible to doxycycline, streptomycin, gentamicin, ciprofloxacin, and moxifloxacin. However, decreased sensitivity to rifampin and trimethoprim-sulfamethoxazole was found in 35.1% and 3.5% of isolates, respectively. Because of the high rates of intermediate sensitivity to rifampin among Brucella isolates, this drug should be prescribed with caution. We recommend restricting the use of rifampin for treatment of brucellosis except as an alternative drug for special situations. |
| doi_str_mv | 10.7883/yoken.JJID.2016.133 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859724917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2014591269</sourcerecordid><originalsourceid>FETCH-LOGICAL-c618t-31a0baf21b13df8e2c8272b61238b629951a320af10142773f84cf46b9b859893</originalsourceid><addsrcrecordid>eNpdkU-PEyEYxonRuH_0E5gYEi8enMq_AebY7brubDbxoJ4JUGalTqECc-i3l2lro16Aw-958vL-AHiD0UJIST_u408XFg8P_e2CIMwXmNJn4BJLyRoiKX9e35SxhlPELsBVzhuESNti9BJcENFK1Ir2Ekyr0Qdv9Qh1WMNbr59CzMVbuMw7Z0uGcYA3abJuHGP2-UAtQ_Fbb1M0vua-Ttm6XfHGj77s_-I17HMcdXEZ-gDv9datdfgA-6TDK_Bi0GN2r0_3Nfh-9-nb6r55_PK5Xy0fG8uxLA3FGhk9EGwwXQ_SESuJIIZjQqXhpOtarClBesAIMyIEHSSzA-OmM7LtZEevwftj7y7FX5PLRW19PswWXJyywhUThHVYVPTdf-gmTinU6VTdLms7TPhcSI9U_X3OyQ1ql_xWp73CSM1W1MGKmq3MOa6qlZp6e-qeTN3COfNHQwX6I7DJRT-5M6BTVTG6U6lAis7HP-Vnxv7QSblAfwM2Z6OJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2014591269</pqid></control><display><type>article</type><title>Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>Asadi, Fatemeh Torkaman ; Hashemi, Seyyed Hamid ; Alikhani, Mohammad Yousef ; Moghimbeigi, Abbas ; Naseri, Zahra</creator><creatorcontrib>Asadi, Fatemeh Torkaman ; Hashemi, Seyyed Hamid ; Alikhani, Mohammad Yousef ; Moghimbeigi, Abbas ; Naseri, Zahra</creatorcontrib><description>Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinical isolates to 7 antibiotics was assessed by the E-test method. One hundred forty-nine patients with brucellosis were evaluated. 38.3% of cultures of clinical samples were positive for BACTEC system, of which 91.2% were associated with a positive serological test result. No significant associations were found between serology and the culture method. All Brucella isolates were susceptible to doxycycline, streptomycin, gentamicin, ciprofloxacin, and moxifloxacin. However, decreased sensitivity to rifampin and trimethoprim-sulfamethoxazole was found in 35.1% and 3.5% of isolates, respectively. Because of the high rates of intermediate sensitivity to rifampin among Brucella isolates, this drug should be prescribed with caution. We recommend restricting the use of rifampin for treatment of brucellosis except as an alternative drug for special situations.</description><identifier>ISSN: 1344-6304</identifier><identifier>EISSN: 1884-2836</identifier><identifier>DOI: 10.7883/yoken.JJID.2016.133</identifier><identifier>PMID: 27580575</identifier><language>eng</language><publisher>Japan: National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antiinfectives and antibacterials ; Brucella ; Brucella melitensis - drug effects ; Brucella melitensis - isolation & purification ; Brucellosis ; Brucellosis - diagnosis ; Brucellosis - epidemiology ; Brucellosis - microbiology ; Brucellosis - pathology ; Child ; Ciprofloxacin ; Clinical isolates ; Diagnostic systems ; Disk Diffusion Antimicrobial Tests ; Doxycycline ; drug resistance ; Drug Resistance, Bacterial ; E-test ; Female ; Gentamicin ; Humans ; Iran - epidemiology ; Male ; Middle Aged ; Moxifloxacin ; Patients ; Prevalence ; Rifampin ; Sensitivity ; Serological tests ; Serology ; Streptomycin ; Sulfamethoxazole ; Test methods ; Trimethoprim ; Trimethoprim-sulfamethoxazole ; Young Adult</subject><ispartof>Japanese Journal of Infectious Diseases, 2017, Vol.70(3), pp.235-238</ispartof><rights>Authors</rights><rights>Copyright Japan Science and Technology Agency 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-31a0baf21b13df8e2c8272b61238b629951a320af10142773f84cf46b9b859893</citedby><cites>FETCH-LOGICAL-c618t-31a0baf21b13df8e2c8272b61238b629951a320af10142773f84cf46b9b859893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1879,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27580575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asadi, Fatemeh Torkaman</creatorcontrib><creatorcontrib>Hashemi, Seyyed Hamid</creatorcontrib><creatorcontrib>Alikhani, Mohammad Yousef</creatorcontrib><creatorcontrib>Moghimbeigi, Abbas</creatorcontrib><creatorcontrib>Naseri, Zahra</creatorcontrib><title>Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran</title><title>Japanese Journal of Infectious Diseases</title><addtitle>Jpn J Infect Dis</addtitle><description>Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinical isolates to 7 antibiotics was assessed by the E-test method. One hundred forty-nine patients with brucellosis were evaluated. 38.3% of cultures of clinical samples were positive for BACTEC system, of which 91.2% were associated with a positive serological test result. No significant associations were found between serology and the culture method. All Brucella isolates were susceptible to doxycycline, streptomycin, gentamicin, ciprofloxacin, and moxifloxacin. However, decreased sensitivity to rifampin and trimethoprim-sulfamethoxazole was found in 35.1% and 3.5% of isolates, respectively. Because of the high rates of intermediate sensitivity to rifampin among Brucella isolates, this drug should be prescribed with caution. We recommend restricting the use of rifampin for treatment of brucellosis except as an alternative drug for special situations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Brucella</subject><subject>Brucella melitensis - drug effects</subject><subject>Brucella melitensis - isolation & purification</subject><subject>Brucellosis</subject><subject>Brucellosis - diagnosis</subject><subject>Brucellosis - epidemiology</subject><subject>Brucellosis - microbiology</subject><subject>Brucellosis - pathology</subject><subject>Child</subject><subject>Ciprofloxacin</subject><subject>Clinical isolates</subject><subject>Diagnostic systems</subject><subject>Disk Diffusion Antimicrobial Tests</subject><subject>Doxycycline</subject><subject>drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>E-test</subject><subject>Female</subject><subject>Gentamicin</subject><subject>Humans</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Moxifloxacin</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Rifampin</subject><subject>Sensitivity</subject><subject>Serological tests</subject><subject>Serology</subject><subject>Streptomycin</subject><subject>Sulfamethoxazole</subject><subject>Test methods</subject><subject>Trimethoprim</subject><subject>Trimethoprim-sulfamethoxazole</subject><subject>Young Adult</subject><issn>1344-6304</issn><issn>1884-2836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU-PEyEYxonRuH_0E5gYEi8enMq_AebY7brubDbxoJ4JUGalTqECc-i3l2lro16Aw-958vL-AHiD0UJIST_u408XFg8P_e2CIMwXmNJn4BJLyRoiKX9e35SxhlPELsBVzhuESNti9BJcENFK1Ir2Ekyr0Qdv9Qh1WMNbr59CzMVbuMw7Z0uGcYA3abJuHGP2-UAtQ_Fbb1M0vua-Ttm6XfHGj77s_-I17HMcdXEZ-gDv9datdfgA-6TDK_Bi0GN2r0_3Nfh-9-nb6r55_PK5Xy0fG8uxLA3FGhk9EGwwXQ_SESuJIIZjQqXhpOtarClBesAIMyIEHSSzA-OmM7LtZEevwftj7y7FX5PLRW19PswWXJyywhUThHVYVPTdf-gmTinU6VTdLms7TPhcSI9U_X3OyQ1ql_xWp73CSM1W1MGKmq3MOa6qlZp6e-qeTN3COfNHQwX6I7DJRT-5M6BTVTG6U6lAis7HP-Vnxv7QSblAfwM2Z6OJ</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Asadi, Fatemeh Torkaman</creator><creator>Hashemi, Seyyed Hamid</creator><creator>Alikhani, Mohammad Yousef</creator><creator>Moghimbeigi, Abbas</creator><creator>Naseri, Zahra</creator><general>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2017</creationdate><title>Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran</title><author>Asadi, Fatemeh Torkaman ; Hashemi, Seyyed Hamid ; Alikhani, Mohammad Yousef ; Moghimbeigi, Abbas ; Naseri, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-31a0baf21b13df8e2c8272b61238b629951a320af10142773f84cf46b9b859893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Brucella</topic><topic>Brucella melitensis - drug effects</topic><topic>Brucella melitensis - isolation & purification</topic><topic>Brucellosis</topic><topic>Brucellosis - diagnosis</topic><topic>Brucellosis - epidemiology</topic><topic>Brucellosis - microbiology</topic><topic>Brucellosis - pathology</topic><topic>Child</topic><topic>Ciprofloxacin</topic><topic>Clinical isolates</topic><topic>Diagnostic systems</topic><topic>Disk Diffusion Antimicrobial Tests</topic><topic>Doxycycline</topic><topic>drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>E-test</topic><topic>Female</topic><topic>Gentamicin</topic><topic>Humans</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Moxifloxacin</topic><topic>Patients</topic><topic>Prevalence</topic><topic>Rifampin</topic><topic>Sensitivity</topic><topic>Serological tests</topic><topic>Serology</topic><topic>Streptomycin</topic><topic>Sulfamethoxazole</topic><topic>Test methods</topic><topic>Trimethoprim</topic><topic>Trimethoprim-sulfamethoxazole</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asadi, Fatemeh Torkaman</creatorcontrib><creatorcontrib>Hashemi, Seyyed Hamid</creatorcontrib><creatorcontrib>Alikhani, Mohammad Yousef</creatorcontrib><creatorcontrib>Moghimbeigi, Abbas</creatorcontrib><creatorcontrib>Naseri, Zahra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Journal of Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asadi, Fatemeh Torkaman</au><au>Hashemi, Seyyed Hamid</au><au>Alikhani, Mohammad Yousef</au><au>Moghimbeigi, Abbas</au><au>Naseri, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran</atitle><jtitle>Japanese Journal of Infectious Diseases</jtitle><addtitle>Jpn J Infect Dis</addtitle><date>2017</date><risdate>2017</risdate><volume>70</volume><issue>3</issue><spage>235</spage><epage>238</epage><pages>235-238</pages><issn>1344-6304</issn><eissn>1884-2836</eissn><abstract>Current drug regimens for brucellosis are associated with relatively high rates of therapeutic failure or relapse. Reduced antimicrobial susceptibility of Brucella spp. has been proposed recently as a potential cause of therapeutic failure. The aim of this study was to evaluate the antibiotic resistance pattern of Brucella melitensis clinical isolates by E-test method in Hamadan, west of Iran. In a 15-month period, all patients with suspected brucellosis were enrolled. Blood specimens were collected for diagnosis of brucellosis by BACTEC system and serological tests. Antimicrobial susceptibility of clinical isolates to 7 antibiotics was assessed by the E-test method. One hundred forty-nine patients with brucellosis were evaluated. 38.3% of cultures of clinical samples were positive for BACTEC system, of which 91.2% were associated with a positive serological test result. No significant associations were found between serology and the culture method. All Brucella isolates were susceptible to doxycycline, streptomycin, gentamicin, ciprofloxacin, and moxifloxacin. However, decreased sensitivity to rifampin and trimethoprim-sulfamethoxazole was found in 35.1% and 3.5% of isolates, respectively. Because of the high rates of intermediate sensitivity to rifampin among Brucella isolates, this drug should be prescribed with caution. We recommend restricting the use of rifampin for treatment of brucellosis except as an alternative drug for special situations.</abstract><cop>Japan</cop><pub>National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee</pub><pmid>27580575</pmid><doi>10.7883/yoken.JJID.2016.133</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1344-6304 |
| ispartof | Japanese Journal of Infectious Diseases, 2017, Vol.70(3), pp.235-238 |
| issn | 1344-6304 1884-2836 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859724917 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antiinfectives and antibacterials Brucella Brucella melitensis - drug effects Brucella melitensis - isolation & purification Brucellosis Brucellosis - diagnosis Brucellosis - epidemiology Brucellosis - microbiology Brucellosis - pathology Child Ciprofloxacin Clinical isolates Diagnostic systems Disk Diffusion Antimicrobial Tests Doxycycline drug resistance Drug Resistance, Bacterial E-test Female Gentamicin Humans Iran - epidemiology Male Middle Aged Moxifloxacin Patients Prevalence Rifampin Sensitivity Serological tests Serology Streptomycin Sulfamethoxazole Test methods Trimethoprim Trimethoprim-sulfamethoxazole Young Adult |
| title | Clinical and Diagnostic Aspects of Brucellosis and Antimicrobial Susceptibility of Brucella Isolates in Hamedan, Iran |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T05%3A23%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20and%20Diagnostic%20Aspects%20of%20Brucellosis%20and%20Antimicrobial%20Susceptibility%20of%20Brucella%20Isolates%20in%20Hamedan,%20Iran&rft.jtitle=Japanese%20Journal%20of%20Infectious%20Diseases&rft.au=Asadi,%20Fatemeh%20Torkaman&rft.date=2017&rft.volume=70&rft.issue=3&rft.spage=235&rft.epage=238&rft.pages=235-238&rft.issn=1344-6304&rft.eissn=1884-2836&rft_id=info:doi/10.7883/yoken.JJID.2016.133&rft_dat=%3Cproquest_cross%3E2014591269%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2014591269&rft_id=info:pmid/27580575&rfr_iscdi=true |