Synthesis of 2α- and 2β-(3-hydroxypropyl)- 7,8-cis-14-epi-1α,25-dihydroxy-19-norvitamin D3 and their biological activity

[Display omitted] •Two novel 7,8-cis-14-epi-1α,25-dihydroxy-19-norvitamin D3 analogs were synthesized.•HVDR binding affinity and osteocalcin promoter transactivation activity were tested.•2β-Substituted analog showed higher binding affinity for hVDR than the 2α-isomer. According to the binding mode...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2017-10, Vol.173, p.79-82
Hauptverfasser:	Sawada, Daisuke, Ochiai, Eiji, Takeuchi, Akiko, Kakuda, Shinji, Kamimura-Takimoto, Midori, Kawagoe, Fumihiro, Kittaka, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-cis-19-norvitamin D3 analog Synthesis Transactivation VDR binding affinity Vitamin D receptor
Online-Zugang:	Volltext
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