Involvement of CX3CL1 in the Migration of Osteoclast Precursors Across Osteoblast Layer Stimulated by Interleukin‐1ß

The trigger for bone remodeling is bone resorption by osteoclasts. Osteoclast differentiation only occurs on the old bone, which needs to be repaired under physiological conditions. However, uncontrolled bone resorption is often observed in pro‐inflammatory bone diseases, such as rheumatoid arthriti...

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Veröffentlicht in:	Journal of cellular physiology 2017-07, Vol.232 (7), p.1739-1745
Hauptverfasser:	Matsuura, Tsuyoshi, Ichinose, Shizuko, Akiyama, Masako, Kasahara, Yuki, Tachikawa, Noriko, Nakahama, Ken‐ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cell Adhesion Molecules - metabolism Cell Count Cell Movement - drug effects Chemokine CX3CL1 - metabolism Dinoprostone - pharmacology HEK293 Cells Humans Interleukin-1beta - pharmacology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Male Mice Neutralization Tests Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - ultrastructure Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects Rheumatoid arthritis Time-Lapse Imaging
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