Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells

Withania somnifera has immense pharmacologic and clinical uses. Owing to its similar pharmacologic activity as that of Korean Ginseng tea, it is popularly called as Indian ginseng. In most cases, extracts of this plant have been evaluated against various diseases or models of disease. However, littl...

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Veröffentlicht in:	Molecular neurobiology 2017-09, Vol.54 (7), p.5061-5073
Hauptverfasser:	Dar, Nawab John, Bhat, Javeed Ahmad, Satti, Naresh Kumar, Sharma, Parduman Raj, Hamid, Abid, Ahmad, Muzamil
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Animals Bcl-2 protein Biomedical and Life Sciences Biomedicine Calcium (intracellular) Caspase Cell Biology Cell Differentiation - drug effects Cells Cytochrome c Death DNA damage Excitotoxicity Ginseng Glutamic acid receptors (ionotropic) Lipid peroxidation Malondialdehyde Membrane potential Membrane Potential, Mitochondrial - drug effects Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism N-Methyl-D-aspartic acid receptors Neurobiology Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neurology Neurons Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neurosciences Peroxidation Plant extracts Poly(ADP-ribose) Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Retinoic acid Tea Toxicity Triterpenes - pharmacology
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