Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves
Background Bicuspid aortic valve (BAV), the most frequent congenital cardiac abnormality, is associated with a higher risk for ascending aortic aneurysms and aorta-related complications (ie, dissection and rupture). The aim of this study was to quantify granular media calcinosis (GMC) in the ascendi...
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| Veröffentlicht in: | The Annals of thoracic surgery 2017-04, Vol.103 (4), p.1178-1185 |
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| creator | Haunschild, Josephina, MD Schellinger, Isabel N., MD von Salisch, Sandy, SD Bakhtiary, Farhad, MD, PhD Misfeld, Martin, MD, PhD Mohr, Friedrich Wilhelm, MD, PhD Raaz, Uwe, MD Etz, Christian D., MD, PhD |
| description | Background Bicuspid aortic valve (BAV), the most frequent congenital cardiac abnormality, is associated with a higher risk for ascending aortic aneurysms and aorta-related complications (ie, dissection and rupture). The aim of this study was to quantify granular media calcinosis (GMC) in the ascending aortic wall of patients with BAV. Methods We analyzed samples of the ascending aorta from patients with BAV (n = 54) and patients with tricuspid aortic valve (TAV) (n = 33) who underwent aortic repair, regarding medial thickness and diameter expansion. Additionally, the convexity and concavity of the samples were stained for GMC and elastin fragmentation. Results The quantitative analysis revealed a significantly higher extent of GMC in patients with BAV at the aortic convexity and concavity compared with patients with TAV, independent of aortic diameter. Additionally, GMC increased with enlargement of the aortic diameter in patients with BAV. Furthermore, we found a significantly reduced total medial thickness in patients with BAV compared with patients with TAV. Conclusions Our findings highlight GMC as a prominent feature of bicuspid aortopathy. |
| doi_str_mv | 10.1016/j.athoracsur.2016.07.018 |
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The aim of this study was to quantify granular media calcinosis (GMC) in the ascending aortic wall of patients with BAV. Methods We analyzed samples of the ascending aorta from patients with BAV (n = 54) and patients with tricuspid aortic valve (TAV) (n = 33) who underwent aortic repair, regarding medial thickness and diameter expansion. Additionally, the convexity and concavity of the samples were stained for GMC and elastin fragmentation. Results The quantitative analysis revealed a significantly higher extent of GMC in patients with BAV at the aortic convexity and concavity compared with patients with TAV, independent of aortic diameter. Additionally, GMC increased with enlargement of the aortic diameter in patients with BAV. Furthermore, we found a significantly reduced total medial thickness in patients with BAV compared with patients with TAV. Conclusions Our findings highlight GMC as a prominent feature of bicuspid aortopathy.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2016.07.018</identifier><identifier>PMID: 27666780</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aged ; Aortic Diseases - etiology ; Aortic Diseases - pathology ; Aortic Valve - abnormalities ; Aortic Valve - pathology ; Bicuspid Aortic Valve Disease ; Calcinosis - etiology ; Calcinosis - pathology ; Cardiothoracic Surgery ; Cohort Studies ; Female ; Heart Valve Diseases - complications ; Heart Valve Diseases - pathology ; Humans ; Male ; Middle Aged ; Risk Factors ; Surgery ; Tricuspid Valve ; Tunica Media - pathology</subject><ispartof>The Annals of thoracic surgery, 2017-04, Vol.103 (4), p.1178-1185</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2017 The Society of Thoracic Surgeons</rights><rights>Copyright © 2017 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-8e79f2e341f01e7f31ee7d116f9bc78b52019fcd44a5ec6c2d849907ac0ec10b3</citedby><cites>FETCH-LOGICAL-c429t-8e79f2e341f01e7f31ee7d116f9bc78b52019fcd44a5ec6c2d849907ac0ec10b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27666780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haunschild, Josephina, MD</creatorcontrib><creatorcontrib>Schellinger, Isabel N., MD</creatorcontrib><creatorcontrib>von Salisch, Sandy, SD</creatorcontrib><creatorcontrib>Bakhtiary, Farhad, MD, PhD</creatorcontrib><creatorcontrib>Misfeld, Martin, MD, PhD</creatorcontrib><creatorcontrib>Mohr, Friedrich Wilhelm, MD, PhD</creatorcontrib><creatorcontrib>Raaz, Uwe, MD</creatorcontrib><creatorcontrib>Etz, Christian D., MD, PhD</creatorcontrib><title>Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background Bicuspid aortic valve (BAV), the most frequent congenital cardiac abnormality, is associated with a higher risk for ascending aortic aneurysms and aorta-related complications (ie, dissection and rupture). The aim of this study was to quantify granular media calcinosis (GMC) in the ascending aortic wall of patients with BAV. Methods We analyzed samples of the ascending aorta from patients with BAV (n = 54) and patients with tricuspid aortic valve (TAV) (n = 33) who underwent aortic repair, regarding medial thickness and diameter expansion. Additionally, the convexity and concavity of the samples were stained for GMC and elastin fragmentation. Results The quantitative analysis revealed a significantly higher extent of GMC in patients with BAV at the aortic convexity and concavity compared with patients with TAV, independent of aortic diameter. Additionally, GMC increased with enlargement of the aortic diameter in patients with BAV. Furthermore, we found a significantly reduced total medial thickness in patients with BAV compared with patients with TAV. Conclusions Our findings highlight GMC as a prominent feature of bicuspid aortopathy.</description><subject>Aged</subject><subject>Aortic Diseases - etiology</subject><subject>Aortic Diseases - pathology</subject><subject>Aortic Valve - abnormalities</subject><subject>Aortic Valve - pathology</subject><subject>Bicuspid Aortic Valve Disease</subject><subject>Calcinosis - etiology</subject><subject>Calcinosis - pathology</subject><subject>Cardiothoracic Surgery</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Heart Valve Diseases - complications</subject><subject>Heart Valve Diseases - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Tricuspid Valve</subject><subject>Tunica Media - pathology</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1vFDEMhiMEosvCX0A5cpkhyXxkckFqV9AiFVGphR6jrMejzZKdWeJMpf77ZrVbkDhxsmy_ry0_ZoxLUUoh24_b0qXNFB3QHEuVK6XQpZDdC7aQTaOKVjXmJVsIIaqiNro5Y2-ItjlVuf2anSndtq3uxILBZXTjHFzk37D3jq9cAD9O5In7kacN8vMpJg_83oVAfBr4jUsex0T83qcNv_Aw09733I09v4vP2cn004UHpLfs1eAC4btTXLIfXz7fra6K6--XX1fn1wXUyqSiQ20GhVUtByFRD5VE1L2U7WDWoLt1kw81A_R17RqEFlTf1cYI7UAgSLGuluzDce4-Tr9npGR3ngBDcCNOM1nZNUYrWWcqS9YdpRAnooiD3Ue_c_HRSmEPiO3W_kVsD4it0DYjztb3py3zeof9H-Mz0yy4OAow3_rgMVqCTAwy34iQbD_5_9ny6Z8hEPzowYVf-Ii0neY4ZpZWWlJW2NvDqw-flm0ljKzq6gmFfKe_</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Haunschild, Josephina, MD</creator><creator>Schellinger, Isabel N., MD</creator><creator>von Salisch, Sandy, SD</creator><creator>Bakhtiary, Farhad, MD, PhD</creator><creator>Misfeld, Martin, MD, PhD</creator><creator>Mohr, Friedrich Wilhelm, MD, PhD</creator><creator>Raaz, Uwe, MD</creator><creator>Etz, Christian D., MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170401</creationdate><title>Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves</title><author>Haunschild, Josephina, MD ; Schellinger, Isabel N., MD ; von Salisch, Sandy, SD ; Bakhtiary, Farhad, MD, PhD ; Misfeld, Martin, MD, PhD ; Mohr, Friedrich Wilhelm, MD, PhD ; Raaz, Uwe, MD ; Etz, Christian D., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-8e79f2e341f01e7f31ee7d116f9bc78b52019fcd44a5ec6c2d849907ac0ec10b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aortic Diseases - etiology</topic><topic>Aortic Diseases - pathology</topic><topic>Aortic Valve - abnormalities</topic><topic>Aortic Valve - pathology</topic><topic>Bicuspid Aortic Valve Disease</topic><topic>Calcinosis - etiology</topic><topic>Calcinosis - pathology</topic><topic>Cardiothoracic Surgery</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Heart Valve Diseases - complications</topic><topic>Heart Valve Diseases - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Tricuspid Valve</topic><topic>Tunica Media - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haunschild, Josephina, MD</creatorcontrib><creatorcontrib>Schellinger, Isabel N., MD</creatorcontrib><creatorcontrib>von Salisch, Sandy, SD</creatorcontrib><creatorcontrib>Bakhtiary, Farhad, MD, PhD</creatorcontrib><creatorcontrib>Misfeld, Martin, MD, PhD</creatorcontrib><creatorcontrib>Mohr, Friedrich Wilhelm, MD, PhD</creatorcontrib><creatorcontrib>Raaz, Uwe, MD</creatorcontrib><creatorcontrib>Etz, Christian D., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haunschild, Josephina, MD</au><au>Schellinger, Isabel N., MD</au><au>von Salisch, Sandy, SD</au><au>Bakhtiary, Farhad, MD, PhD</au><au>Misfeld, Martin, MD, PhD</au><au>Mohr, Friedrich Wilhelm, MD, PhD</au><au>Raaz, Uwe, MD</au><au>Etz, Christian D., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>103</volume><issue>4</issue><spage>1178</spage><epage>1185</epage><pages>1178-1185</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Background Bicuspid aortic valve (BAV), the most frequent congenital cardiac abnormality, is associated with a higher risk for ascending aortic aneurysms and aorta-related complications (ie, dissection and rupture). The aim of this study was to quantify granular media calcinosis (GMC) in the ascending aortic wall of patients with BAV. Methods We analyzed samples of the ascending aorta from patients with BAV (n = 54) and patients with tricuspid aortic valve (TAV) (n = 33) who underwent aortic repair, regarding medial thickness and diameter expansion. Additionally, the convexity and concavity of the samples were stained for GMC and elastin fragmentation. Results The quantitative analysis revealed a significantly higher extent of GMC in patients with BAV at the aortic convexity and concavity compared with patients with TAV, independent of aortic diameter. Additionally, GMC increased with enlargement of the aortic diameter in patients with BAV. Furthermore, we found a significantly reduced total medial thickness in patients with BAV compared with patients with TAV. Conclusions Our findings highlight GMC as a prominent feature of bicuspid aortopathy.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>27666780</pmid><doi>10.1016/j.athoracsur.2016.07.018</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aortic Diseases - etiology Aortic Diseases - pathology Aortic Valve - abnormalities Aortic Valve - pathology Bicuspid Aortic Valve Disease Calcinosis - etiology Calcinosis - pathology Cardiothoracic Surgery Cohort Studies Female Heart Valve Diseases - complications Heart Valve Diseases - pathology Humans Male Middle Aged Risk Factors Surgery Tricuspid Valve Tunica Media - pathology |
| title | Granular Media Calcinosis in the Aortic Walls of Patients With Bicuspid and Tricuspid Aortic Valves |
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