Corneal Elevation Topography in Primary Open Angle Glaucoma
PURPOSE OF THE STUDY:The purpose of the study was to describe and compare anterior and posterior topographic elevation maps in primary open angle glaucoma patients with functional damage staging and in healthy controls. METHODS:A total of 217 subjects were consecutively recruited, including 111 prim...
Gespeichert in:
| Veröffentlicht in: | Journal of glaucoma 2017-02, Vol.26 (2), p.e41-e45 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e45 |
|---|---|
| container_issue | 2 |
| container_start_page | e41 |
| container_title | Journal of glaucoma |
| container_volume | 26 |
| creator | Gil, Pedro Pires, Joana Matos, Rita Cardoso, Mariana S Lopes, Nádia Matias, João Mariano, Manuel |
| description | PURPOSE OF THE STUDY:The purpose of the study was to describe and compare anterior and posterior topographic elevation maps in primary open angle glaucoma patients with functional damage staging and in healthy controls.
METHODS:A total of 217 subjects were consecutively recruited, including 111 primary open angle glaucoma patients (patients), and 106 healthy individuals (controls). All patients performed Pentacam HR corneal topography. Mean anterior keratometry and anterior and posterior topographic elevation maps were compared in the central 3, 5, and 7 mm. Humphrey automated perimetry results from the patient group were classified according to the Glaucoma Staging System.
RESULTS:Age (patients72.32±8.09; controls70.82±8.36; P=0.18) and central corneal pachymetry (patients541.13±36.98; controls548.67±34.56; P=0.12) were similar in both groups. Maximum elevation readings in the central 5 mm were significantly (P |
| doi_str_mv | 10.1097/IJG.0000000000000535 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1859719937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1859719937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3565-f0984ebfcdb073fc27d6bd535e28811014f56b12123989c09083beb7866162fb3</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0EolB4A4Ry5JLinzi2xamqSimqVA5F4mbZidMG3DjYCVXfnqAUhDiwl93DzOzoA-AKwRGCgt3OH2cj-HsooUfgDFGSxglHL8fdDSmLIcdiAM5DeIUQQ4zRKRhgRoVAjJ-Bu4nzlVE2mlrzoZrSVdHK1W7tVb3ZR2UVPflyq_w-WtamisbV2ppoZlWbua26ACeFssFcHvYQPN9PV5OHeLGczSfjRZwRmtK4gIInRhdZriEjRYZZnuq8a2sw5whBlBQ01QgjTAQXGRSQE20042mKUlxoMgQ3fW7t3XtrQiO3ZciMtaoyrg0ScSoYEoKwTpr00sy7ELwpZN33lwjKL2yywyb_Yuts14cPrd6a_Mf0zakT8F6wc7YxPrzZdme83HTkms3_2Z_Q4XdI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1859719937</pqid></control><display><type>article</type><title>Corneal Elevation Topography in Primary Open Angle Glaucoma</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Gil, Pedro ; Pires, Joana ; Matos, Rita ; Cardoso, Mariana S ; Lopes, Nádia ; Matias, João ; Mariano, Manuel</creator><creatorcontrib>Gil, Pedro ; Pires, Joana ; Matos, Rita ; Cardoso, Mariana S ; Lopes, Nádia ; Matias, João ; Mariano, Manuel</creatorcontrib><description>PURPOSE OF THE STUDY:The purpose of the study was to describe and compare anterior and posterior topographic elevation maps in primary open angle glaucoma patients with functional damage staging and in healthy controls.
METHODS:A total of 217 subjects were consecutively recruited, including 111 primary open angle glaucoma patients (patients), and 106 healthy individuals (controls). All patients performed Pentacam HR corneal topography. Mean anterior keratometry and anterior and posterior topographic elevation maps were compared in the central 3, 5, and 7 mm. Humphrey automated perimetry results from the patient group were classified according to the Glaucoma Staging System.
RESULTS:Age (patients72.32±8.09; controls70.82±8.36; P=0.18) and central corneal pachymetry (patients541.13±36.98; controls548.67±34.56; P=0.12) were similar in both groups. Maximum elevation readings in the central 5 mm were significantly (P<0.05) higher in the anterior (patients8.21±8.63; controls5.79±3.62) and posterior (patients16.17±8.72; controls13.92±6.03) corneal topography of the glaucomatous patients, as well as in the anterior (patients17.32±20.78; controls9.61±5.64) and posterior (patients38.81±19.78; controls26.38±12.73) central 7 mm. There was a weak but significant correlation between the Glaucoma Staging System stage and both the anterior 5 mm (r=0.397) and 7 mm (r=0.304) maximum, as well as the posterior 5 mm (r=0.233) and 7 mm (r=0.241) maximum.
CONCLUSIONS:In patients with primary open angle glaucoma, there is a forward shifting of the posterior and anterior corneal surfaces. This appears to be correlated with more advanced stages of functional damage, pointing to a possible link between corneal structural changes and duration and intensity of elevated intraocular pressure. Further studies may ascertain the potential for this biological marker to be used in monitoring primary open angle glaucoma patients.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0000000000000535</identifier><identifier>PMID: 27599178</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Aged ; Cornea - pathology ; Corneal Diseases - diagnosis ; Corneal Diseases - etiology ; Corneal Diseases - physiopathology ; Corneal Pachymetry ; Corneal Topography ; Female ; Glaucoma, Open-Angle - complications ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Humans ; Intraocular Pressure ; Male</subject><ispartof>Journal of glaucoma, 2017-02, Vol.26 (2), p.e41-e45</ispartof><rights>Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3565-f0984ebfcdb073fc27d6bd535e28811014f56b12123989c09083beb7866162fb3</citedby><cites>FETCH-LOGICAL-c3565-f0984ebfcdb073fc27d6bd535e28811014f56b12123989c09083beb7866162fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27599178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gil, Pedro</creatorcontrib><creatorcontrib>Pires, Joana</creatorcontrib><creatorcontrib>Matos, Rita</creatorcontrib><creatorcontrib>Cardoso, Mariana S</creatorcontrib><creatorcontrib>Lopes, Nádia</creatorcontrib><creatorcontrib>Matias, João</creatorcontrib><creatorcontrib>Mariano, Manuel</creatorcontrib><title>Corneal Elevation Topography in Primary Open Angle Glaucoma</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE OF THE STUDY:The purpose of the study was to describe and compare anterior and posterior topographic elevation maps in primary open angle glaucoma patients with functional damage staging and in healthy controls.
METHODS:A total of 217 subjects were consecutively recruited, including 111 primary open angle glaucoma patients (patients), and 106 healthy individuals (controls). All patients performed Pentacam HR corneal topography. Mean anterior keratometry and anterior and posterior topographic elevation maps were compared in the central 3, 5, and 7 mm. Humphrey automated perimetry results from the patient group were classified according to the Glaucoma Staging System.
RESULTS:Age (patients72.32±8.09; controls70.82±8.36; P=0.18) and central corneal pachymetry (patients541.13±36.98; controls548.67±34.56; P=0.12) were similar in both groups. Maximum elevation readings in the central 5 mm were significantly (P<0.05) higher in the anterior (patients8.21±8.63; controls5.79±3.62) and posterior (patients16.17±8.72; controls13.92±6.03) corneal topography of the glaucomatous patients, as well as in the anterior (patients17.32±20.78; controls9.61±5.64) and posterior (patients38.81±19.78; controls26.38±12.73) central 7 mm. There was a weak but significant correlation between the Glaucoma Staging System stage and both the anterior 5 mm (r=0.397) and 7 mm (r=0.304) maximum, as well as the posterior 5 mm (r=0.233) and 7 mm (r=0.241) maximum.
CONCLUSIONS:In patients with primary open angle glaucoma, there is a forward shifting of the posterior and anterior corneal surfaces. This appears to be correlated with more advanced stages of functional damage, pointing to a possible link between corneal structural changes and duration and intensity of elevated intraocular pressure. Further studies may ascertain the potential for this biological marker to be used in monitoring primary open angle glaucoma patients.</description><subject>Aged</subject><subject>Cornea - pathology</subject><subject>Corneal Diseases - diagnosis</subject><subject>Corneal Diseases - etiology</subject><subject>Corneal Diseases - physiopathology</subject><subject>Corneal Pachymetry</subject><subject>Corneal Topography</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - complications</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Male</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EolB4A4Ry5JLinzi2xamqSimqVA5F4mbZidMG3DjYCVXfnqAUhDiwl93DzOzoA-AKwRGCgt3OH2cj-HsooUfgDFGSxglHL8fdDSmLIcdiAM5DeIUQQ4zRKRhgRoVAjJ-Bu4nzlVE2mlrzoZrSVdHK1W7tVb3ZR2UVPflyq_w-WtamisbV2ppoZlWbua26ACeFssFcHvYQPN9PV5OHeLGczSfjRZwRmtK4gIInRhdZriEjRYZZnuq8a2sw5whBlBQ01QgjTAQXGRSQE20042mKUlxoMgQ3fW7t3XtrQiO3ZciMtaoyrg0ScSoYEoKwTpr00sy7ELwpZN33lwjKL2yywyb_Yuts14cPrd6a_Mf0zakT8F6wc7YxPrzZdme83HTkms3_2Z_Q4XdI</recordid><startdate>201702</startdate><enddate>201702</enddate><creator>Gil, Pedro</creator><creator>Pires, Joana</creator><creator>Matos, Rita</creator><creator>Cardoso, Mariana S</creator><creator>Lopes, Nádia</creator><creator>Matias, João</creator><creator>Mariano, Manuel</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201702</creationdate><title>Corneal Elevation Topography in Primary Open Angle Glaucoma</title><author>Gil, Pedro ; Pires, Joana ; Matos, Rita ; Cardoso, Mariana S ; Lopes, Nádia ; Matias, João ; Mariano, Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3565-f0984ebfcdb073fc27d6bd535e28811014f56b12123989c09083beb7866162fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Cornea - pathology</topic><topic>Corneal Diseases - diagnosis</topic><topic>Corneal Diseases - etiology</topic><topic>Corneal Diseases - physiopathology</topic><topic>Corneal Pachymetry</topic><topic>Corneal Topography</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - complications</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gil, Pedro</creatorcontrib><creatorcontrib>Pires, Joana</creatorcontrib><creatorcontrib>Matos, Rita</creatorcontrib><creatorcontrib>Cardoso, Mariana S</creatorcontrib><creatorcontrib>Lopes, Nádia</creatorcontrib><creatorcontrib>Matias, João</creatorcontrib><creatorcontrib>Mariano, Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gil, Pedro</au><au>Pires, Joana</au><au>Matos, Rita</au><au>Cardoso, Mariana S</au><au>Lopes, Nádia</au><au>Matias, João</au><au>Mariano, Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Elevation Topography in Primary Open Angle Glaucoma</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2017-02</date><risdate>2017</risdate><volume>26</volume><issue>2</issue><spage>e41</spage><epage>e45</epage><pages>e41-e45</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSE OF THE STUDY:The purpose of the study was to describe and compare anterior and posterior topographic elevation maps in primary open angle glaucoma patients with functional damage staging and in healthy controls.
METHODS:A total of 217 subjects were consecutively recruited, including 111 primary open angle glaucoma patients (patients), and 106 healthy individuals (controls). All patients performed Pentacam HR corneal topography. Mean anterior keratometry and anterior and posterior topographic elevation maps were compared in the central 3, 5, and 7 mm. Humphrey automated perimetry results from the patient group were classified according to the Glaucoma Staging System.
RESULTS:Age (patients72.32±8.09; controls70.82±8.36; P=0.18) and central corneal pachymetry (patients541.13±36.98; controls548.67±34.56; P=0.12) were similar in both groups. Maximum elevation readings in the central 5 mm were significantly (P<0.05) higher in the anterior (patients8.21±8.63; controls5.79±3.62) and posterior (patients16.17±8.72; controls13.92±6.03) corneal topography of the glaucomatous patients, as well as in the anterior (patients17.32±20.78; controls9.61±5.64) and posterior (patients38.81±19.78; controls26.38±12.73) central 7 mm. There was a weak but significant correlation between the Glaucoma Staging System stage and both the anterior 5 mm (r=0.397) and 7 mm (r=0.304) maximum, as well as the posterior 5 mm (r=0.233) and 7 mm (r=0.241) maximum.
CONCLUSIONS:In patients with primary open angle glaucoma, there is a forward shifting of the posterior and anterior corneal surfaces. This appears to be correlated with more advanced stages of functional damage, pointing to a possible link between corneal structural changes and duration and intensity of elevated intraocular pressure. Further studies may ascertain the potential for this biological marker to be used in monitoring primary open angle glaucoma patients.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27599178</pmid><doi>10.1097/IJG.0000000000000535</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1057-0829 |
| ispartof | Journal of glaucoma, 2017-02, Vol.26 (2), p.e41-e45 |
| issn | 1057-0829 1536-481X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1859719937 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Cornea - pathology Corneal Diseases - diagnosis Corneal Diseases - etiology Corneal Diseases - physiopathology Corneal Pachymetry Corneal Topography Female Glaucoma, Open-Angle - complications Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Humans Intraocular Pressure Male |
| title | Corneal Elevation Topography in Primary Open Angle Glaucoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T19%3A48%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Corneal%20Elevation%20Topography%20in%20Primary%20Open%20Angle%20Glaucoma&rft.jtitle=Journal%20of%20glaucoma&rft.au=Gil,%20Pedro&rft.date=2017-02&rft.volume=26&rft.issue=2&rft.spage=e41&rft.epage=e45&rft.pages=e41-e45&rft.issn=1057-0829&rft.eissn=1536-481X&rft_id=info:doi/10.1097/IJG.0000000000000535&rft_dat=%3Cproquest_cross%3E1859719937%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1859719937&rft_id=info:pmid/27599178&rfr_iscdi=true |